Determine the necessary mass, volume, or concentration for preparing a solution.
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Basic Description
| Synonyms | 2,3-Dihydroxybenzoic acid | 303-38-8 | Pyrocatechuic acid | o-Pyrocatechuic acid | 2-Pyrocatechuic acid | 3-Hydroxysalicylic acid | Benzoic acid, 2,3-dihydroxy- | DOBK | Catecholcarboxylic acid | 2,3-Dihydroxybenzoicacid | DHBA | dihydroxybenzoic acid | 2,3 DHB | 2,3-DIHYDROXY-BEN |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | 2,3-Dihydroxybenzoic acid was found to be orally effective iron-chelating drug in hypertransfused rat model. It is monocatechol siderophore produced by Brucella abortus. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | 2,3-Dihydroxybenzoic acid was found to be orally effective iron-chelating drug in hypertransfused rat model. It is monocatechol siderophore produced by Brucella abortus. |
Associated Targets(Human)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
TYR Tclin Tyrosinase (717 Activities)
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ALB Tchem Serum albumin (2651 Activities)
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METAP2 Tchem Methionine aminopeptidase 2 (1512 Activities)
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MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
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MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)
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SELL Tchem Leukocyte adhesion molecule-1 (145 Activities)
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MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
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HL-60 (67320 Activities)
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HEK293 (82097 Activities)
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HeLa (62764 Activities)
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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
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ATXN2 Tbio Ataxin-2 (54410 Activities)
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Associated Targets(non-human)
Sele Selectin E (1 Activities)
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Selp P-selectin (7 Activities)
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Nos2 Nitric oxide synthase, inducible (3573 Activities)
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Mmp2 Matrix metalloproteinase-2 (12 Activities)
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Mmp9 Matrix metalloproteinase 9 (38 Activities)
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HD1 Histone deacetylase (38 Activities)
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PC-12 (7051 Activities)
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lef Anthrax lethal factor (7585 Activities)
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ARG1 Arginase-1 (70 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2,3-dihydroxybenzoic acid |
|---|---|
| INCHI | InChI=1S/C7H6O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,8-9H,(H,10,11) |
| InChi Key | GLDQAMYCGOIJDV-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=C(C(=C1)O)O)C(=O)O |
| Isomeric SMILES | C1=CC(=C(C(=C1)O)O)C(=O)O |
| WGK Germany | 2 |
| RTECS | DG8576490 |
| PubChem CID | 19 |
| Molecular Weight | 154.12 |
| Beilstein | 2209120 |
| Reaxy-Rn | 2209117 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Melt Point(°C) | 204-206°C |
|---|
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 2 |
| RTECS | DG8576490 |
| Reaxy-Rn | 2209117 |
Related Documents
Citations of This Product
| 1. Dali Fu, Haodong Wang, Tan Wang, Chunming Xu, Yehua Han. (2023) Structural insights into variation of intramolecular acid site using phase transition experiments and computation. AICHE JOURNAL, 70 (4): (e18342). [PMID:] [10.1002/aic.18342] |
| 2. Xiaomei Yao, Yingbo Fang, Xiaochen Cui, Xian Cheng, Zixia Cheng. (2023) Dielectric Barrier Discharge Plasma Coupled with Cobalt Oxyhydroxide for Methylene Blue Degradation. Toxics, 11 (9): (763). [PMID:37755773] [10.3390/toxics11090763] |
| 3. Fanghua Guo, Li Peng, Hua Xiong, Rong Tsao, Hua Zhang, Li Jiang, Yong Sun. (2023) Bioaccessibility and transport of lentil hull polyphenols in vitro, and their bioavailability and metabolism in rats. FOOD RESEARCH INTERNATIONAL, 167 (112634). [PMID:37087206] [10.1016/j.foodres.2023.112634] |
| 4. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen. (2023) Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential. Food Bioscience, 52 (102508). [PMID:] [10.1016/j.fbio.2023.102508] |
| 5. Yunan Zhang, Yu Duan, Jin Su, Lixin Liu, Yanru Feng, Lili Wu, Lei Zhang, Yunjie Zhang, Dongyu Zou, Yingli Liu. (2021) Inspiration for revival of old drugs: improving solubility and avoiding hygroscopicity of pipemidic acid by forming two pharmaceutical salts based on charge-assisted hydrogen bond recognitions. NEW JOURNAL OF CHEMISTRY, 45 (42): (19704-19713). [PMID:] [10.1039/D1NJ03314J] |
| 6. Deying Meng, Huangmei Zhou, Jianhua Xu, Sanjun Zhang. (2021) Studies on the interaction of salicylic acid and its monohydroxy substituted derivatives with bovine serum albumin. CHEMICAL PHYSICS, 546 (111182). [PMID:] [10.1016/j.chemphys.2021.111182] |
| 7. Lei Xu, Shaoyu Tang, Dan Li, Xiao Ma, Yunqing Zhu, Jianjiang Lu, Junfeng Niu. (2021) Electrochemical degradation of tris(2-chloroethyl) phosphate by metal-oxide-coated Ti anodes: Kinetics, toxicity and mechanism. SEPARATION AND PURIFICATION TECHNOLOGY, 265 (118489). [PMID:] [10.1016/j.seppur.2021.118489] |
| 8. Ren Jingyu, Li Jie, Lv Lei, Wang Jian. (2021) Regeneration of [Bmim]BF4 ionic liquid by ozonation: hydrogen bond roles, synergistic effect, and DFT calculation. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (10): (12909-12917). [PMID:33097991] [10.1007/s11356-020-11298-7] |
| 9. Mingfang Zhu, Hongqing Ye, Mushen Lai, Jianshan Ye, Rui Li, Wenhao Zhang, Huanru Liang, Rongkun Zhu, Huajun Fan, Shi Chen. (2019) The gold nanoparticle sensitized pRGO-MWCNTs grid modified carbon fiber microelectrode as an efficient sensor system for simultaneous detection of three dihydroxybenzoic acid isomers. ELECTROCHIMICA ACTA, 322 (134765). [PMID:] [10.1016/j.electacta.2019.134765] |
| 10. Lei Xu, Xiao Ma, Junfeng Niu, Jie Chen, Chengzhi Zhou. (2019) Removal of trace naproxen from aqueous solution using a laboratory-scale reactive flow-through membrane electrode. JOURNAL OF HAZARDOUS MATERIALS, 379 (120692). [PMID:31255850] [10.1016/j.jhazmat.2019.05.085] |
| 11. Yitao Li, Xingdong Shi, Zhi Zhang, Yazhou Peng. (2019) Enhanced coagulation by high-frequency ultrasound in Microcystis aeruginosa-laden water: Strategies and mechanisms. ULTRASONICS SONOCHEMISTRY, 55 (232). [PMID:30712852] [10.1016/j.ultsonch.2019.01.022] |
| 12. Haifeng Zhou, Malin Cui, Yuan Zhao, Chan Wang, Qijun Song. (2017) Preparation of Nitrogen and FeP Doped Carbon Nanotubes for Selective and Simultaneous Electrochemical Detection of Dihydroxybenzoic Acid Isomers. ELECTROCHIMICA ACTA, 242 (107). [PMID:] [10.1016/j.electacta.2017.05.045] |
References
| 1. Dali Fu, Haodong Wang, Tan Wang, Chunming Xu, Yehua Han. (2023) Structural insights into variation of intramolecular acid site using phase transition experiments and computation. AICHE JOURNAL, 70 (4): (e18342). [PMID:] [10.1002/aic.18342] |
| 2. Xiaomei Yao, Yingbo Fang, Xiaochen Cui, Xian Cheng, Zixia Cheng. (2023) Dielectric Barrier Discharge Plasma Coupled with Cobalt Oxyhydroxide for Methylene Blue Degradation. Toxics, 11 (9): (763). [PMID:37755773] [10.3390/toxics11090763] |
| 3. Fanghua Guo, Li Peng, Hua Xiong, Rong Tsao, Hua Zhang, Li Jiang, Yong Sun. (2023) Bioaccessibility and transport of lentil hull polyphenols in vitro, and their bioavailability and metabolism in rats. FOOD RESEARCH INTERNATIONAL, 167 (112634). [PMID:37087206] [10.1016/j.foodres.2023.112634] |
| 4. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen. (2023) Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential. Food Bioscience, 52 (102508). [PMID:] [10.1016/j.fbio.2023.102508] |
| 5. Yunan Zhang, Yu Duan, Jin Su, Lixin Liu, Yanru Feng, Lili Wu, Lei Zhang, Yunjie Zhang, Dongyu Zou, Yingli Liu. (2021) Inspiration for revival of old drugs: improving solubility and avoiding hygroscopicity of pipemidic acid by forming two pharmaceutical salts based on charge-assisted hydrogen bond recognitions. NEW JOURNAL OF CHEMISTRY, 45 (42): (19704-19713). [PMID:] [10.1039/D1NJ03314J] |
| 6. Deying Meng, Huangmei Zhou, Jianhua Xu, Sanjun Zhang. (2021) Studies on the interaction of salicylic acid and its monohydroxy substituted derivatives with bovine serum albumin. CHEMICAL PHYSICS, 546 (111182). [PMID:] [10.1016/j.chemphys.2021.111182] |
| 7. Lei Xu, Shaoyu Tang, Dan Li, Xiao Ma, Yunqing Zhu, Jianjiang Lu, Junfeng Niu. (2021) Electrochemical degradation of tris(2-chloroethyl) phosphate by metal-oxide-coated Ti anodes: Kinetics, toxicity and mechanism. SEPARATION AND PURIFICATION TECHNOLOGY, 265 (118489). [PMID:] [10.1016/j.seppur.2021.118489] |
| 8. Ren Jingyu, Li Jie, Lv Lei, Wang Jian. (2021) Regeneration of [Bmim]BF4 ionic liquid by ozonation: hydrogen bond roles, synergistic effect, and DFT calculation. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (10): (12909-12917). [PMID:33097991] [10.1007/s11356-020-11298-7] |
| 9. Mingfang Zhu, Hongqing Ye, Mushen Lai, Jianshan Ye, Rui Li, Wenhao Zhang, Huanru Liang, Rongkun Zhu, Huajun Fan, Shi Chen. (2019) The gold nanoparticle sensitized pRGO-MWCNTs grid modified carbon fiber microelectrode as an efficient sensor system for simultaneous detection of three dihydroxybenzoic acid isomers. ELECTROCHIMICA ACTA, 322 (134765). [PMID:] [10.1016/j.electacta.2019.134765] |
| 10. Lei Xu, Xiao Ma, Junfeng Niu, Jie Chen, Chengzhi Zhou. (2019) Removal of trace naproxen from aqueous solution using a laboratory-scale reactive flow-through membrane electrode. JOURNAL OF HAZARDOUS MATERIALS, 379 (120692). [PMID:31255850] [10.1016/j.jhazmat.2019.05.085] |
| 11. Yitao Li, Xingdong Shi, Zhi Zhang, Yazhou Peng. (2019) Enhanced coagulation by high-frequency ultrasound in Microcystis aeruginosa-laden water: Strategies and mechanisms. ULTRASONICS SONOCHEMISTRY, 55 (232). [PMID:30712852] [10.1016/j.ultsonch.2019.01.022] |
| 12. Haifeng Zhou, Malin Cui, Yuan Zhao, Chan Wang, Qijun Song. (2017) Preparation of Nitrogen and FeP Doped Carbon Nanotubes for Selective and Simultaneous Electrochemical Detection of Dihydroxybenzoic Acid Isomers. ELECTROCHIMICA ACTA, 242 (107). [PMID:] [10.1016/j.electacta.2017.05.045] |