2,3-Pyridinedicarboxylic acid - 99%, high purity , CAS No.89-00-9

  • ≥99%
Item Number
P100814
Grouped product items
SKUSizeAvailabilityPrice Qty
P100814-25g
25g
In stock
$21.90
P100814-100g
100g
In stock
$58.90
P100814-500g
500g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90

Endogenous NMDA agonist and transmitter candidate

Basic Description

SynonymsAI3-63017 | KBioGR_000711 | NCGC00015865-08 | NCGC00024506-03 | Tocris-0225 | NSC18836 | NSC-18836 | NCGC00015865-03 | Pyridin-2,3-dicarbonsaeure | BBL007601 | BSPBio_003143 | NCGC00015865-06 | PB47350 | Pyridine-2,3-dicarboxylate | AM81291 | DB01796 | NS
Specifications & Purity≥99%
Biochemical and Physiological MechanismsEndogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.
Shipped InNormal
Product Description

A matabolite of tryptophan and a putative NMDA receptor agonist.

Associated Targets(Human)

AGER Tchem Advanced glycosylation end product-specific receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN2C Tclin Glutamate [NMDA] receptor subunit epsilon 3 (47 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGER Tchem Advanced glycosylation end product-specific receptor (291 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

blaZ Beta-lactamase (285 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Beta-lactamase L1 (242 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA (2103 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaIMP-1 Metallo beta-lactamase (43 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179597
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179597
IUPAC Name pyridine-2,3-dicarboxylic acid
INCHI InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChi Key GJAWHXHKYYXBSV-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(N=C1)C(=O)O)C(=O)O
Isomeric SMILES C1=CC(=C(N=C1)C(=O)O)C(=O)O
WGK Germany 3
RTECS US7967250
Alternate CAS 339155-13-4
PubChem CID 1066
Molecular Weight 167.12
Beilstein 137110
Reaxy-Rn 137110

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
L2015077Certificate of AnalysisOct 15, 2024 P100814
L2015076Certificate of AnalysisOct 15, 2024 P100814
I2409419Certificate of AnalysisSep 13, 2024 P100814
D2412312Certificate of AnalysisMar 15, 2024 P100814
D2412314Certificate of AnalysisMar 15, 2024 P100814
G1531039Certificate of AnalysisApr 11, 2023 P100814
A1903094Certificate of AnalysisOct 20, 2022 P100814
D2324404Certificate of AnalysisJul 07, 2022 P100814
H2209657Certificate of AnalysisJul 07, 2022 P100814
C2209253Certificate of AnalysisJun 21, 2021 P100814
D2324160Certificate of AnalysisJun 21, 2021 P100814

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Chemical and Physical Properties

SolubilitySolvent:1eq. NaOH, Max Conc. mg/mL: 8.36, Max Conc. mM: 50
Melt Point(°C)188-190°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS US7967250
Reaxy-Rn 137110
Merck Index 8073

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References

1. Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ.  (2008)  Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases..  J Med Chem,  51  (22): (7053-6).  [PMID:18942826] [10.1021/op500134e]
2. J D Shoemaker,W H Elliott.  (1991-01-02)  Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease..  Journal of chromatography,  562  ((1-2)): (125-138).  [PMID:2026685]
3. F Moroni,G Lombardi,V Carlà,S Lal,P Etienne,N P Nair.  (1986-12-01)  Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure..  Journal of neurochemistry,  47  ((6)): (1667-1671).  [PMID:2430055]
4. M P Heyes,D Rubinow,C Lane,S P Markey.  (1989-08-01)  Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome..  Annals of neurology,  26  ((2)): (275-277).  [PMID:2528321]
5. T W Stone,J H Connick.  (1985-07-01)  Quinolinic acid and other kynurenines in the central nervous system..  Neuroscience,  15  ((3)): (597-617).  [PMID:2866466]
6. C Power,R T Johnson.  (1995-05-01)  HIV-1 associated dementia: clinical features and pathogenesis..  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,  22  ((2)): (92-100).  [PMID:7627922]
7. K H Jhamandas,R J Boegman,R J Beninger.  (1994-12-01)  The 1993 Upjohn Award Lecture. Quinolinic acid induced brain neurotransmitter deficits: modulation by endogenous excitotoxin antagonists..  Canadian journal of physiology and pharmacology,  72  ((12)): (1473-1482).  [PMID:7736338]
8. M P Heyes.  (1993-02-01)  Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid..  Biochemical Society transactions,  21  ((1)): (83-89).  [PMID:8449360]
9. K Saito,M P Heyes.  (1996-01-01)  Kynurenine pathway enzymes in brain. Properties of enzymes and regulation of quinolinic acid synthesis..  Advances in experimental medicine and biology,  398  (485-492).  [PMID:8906309]
10. M P Heyes,C L Achim,C A Wiley,E O Major,K Saito,S P Markey.  (1996-12-01)  Human microglia convert l-tryptophan into the neurotoxin quinolinic acid..  The Biochemical journal,  320   (( Pt 2)): (595-597).  [PMID:8973572]
11. F Guneral,C Bachmann.  (1994-06-01)  Age-related reference values for urinary organic acids in a healthy Turkish pediatric population..  Clinical chemistry,  40  ((6)): (862-866).  [PMID:8087979]
12. O O Akinyinka,A Sowunmi,R Honeywell,A G Renwick.  (2000-07-06)  The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians..  European journal of clinical pharmacology,  56  ((2)): (159-165).  [PMID:10877011]
13. Hulya Bayir,Valerian E Kagan,Yulia Y Tyurina,Vladimir Tyurin,Randall A Ruppel,P David Adelson,Steven H Graham,Keri Janesko,Robert S B Clark,Patrick M Kochanek.  (2002-04-30)  Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children..  Pediatric research,  51  ((5)): (571-578).  [PMID:11978879]
14. S Pukrittayakamee,P Pitisuttithum,H Zhang,A Jantra,S Wanwimolruk,N J White.  (2002-08-20)  Effects of cigarette smoking on quinine pharmacokinetics in malaria..  European journal of clinical pharmacology,  58  ((5)): (315-319).  [PMID:12185554]
15. Ravi Kumar Kurup,Parameswara Achutha Kurup.  (2002-09-28)  Central role of hypothalamic digoxin in conscious perception, neuroimmunoendocrine integration, and coordination of cellular function: relation to hemispheric dominance..  The International journal of neuroscience,  112  ((6)): (705-739).  [PMID:12325312]
16. Antonio Rodríguez-Núñez,Elena Cid,Javier Rodríguez-García,Félix Camiña,Santiago Rodríguez-Segade,Manuel Castro-Gago.  (2003-02-13)  Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis..  Brain & development,  25  ((2)): (102-106).  [PMID:12581805]
17. George A Smythe,Anne Poljak,Sonia Bustamante,Olgar Braga,Alison Maxwell,Ross Grant,Perminder Sachdev.  (2004-06-23)  ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue..  Advances in experimental medicine and biology,  527  (705-712).  [PMID:15206793]
18. Gilles J Guillemin,Stephen J Kerr,Bruce J Brew.  (2005-01-11)  Involvement of quinolinic acid in AIDS dementia complex..  Neurotoxicity research,  ((1-2)): (103-123).  [PMID:15639803]
19. Gilles J Guillemin,Vincent Meininger,Bruce J Brew.  (2006-08-16)  Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis..  Neuro-degenerative diseases,  ((3-4)): (166-176).  [PMID:16909022]
20. L E Horsfall,G Garau,B M R Liénard,O Dideberg,C J Schofield,J M Frère,M Galleni.  (2007-02-20)  Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila..  Antimicrobial agents and chemotherapy,  51  ((6)): (2136-2142).  [PMID:17307979]
21. Phedias Diamandis,Jan Wildenhain,Ian D Clarke,Adrian G Sacher,Jeremy Graham,David S Bellows,Erick K M Ling,Ryan J Ward,Leanne G Jamieson,Mike Tyers,Peter B Dirks.  (2007-04-10)  Chemical genetics reveals a complex functional ground state of neural stem cells..  Nature chemical biology,  ((5)): (268-273).  [PMID:17417631]
22. Han Zhou,Zhi-Bin Chen,Hui-Qin Tian,Xia Xu,Yong-Qing Wang,Guang-Qian Xing,Lei Cheng.  (2012-05-10)  Effects of hypoxia-inducible factor 1α on bone conduction impairment in otitis media with effusion..  Acta oto-laryngologica,  132  ((9)): (938-943).  [PMID:22568633]
23. Fernando Dobrachinski,Luiza Lena Bastos,Jessika Cristina Bridi,Cristiane Lenz Dalla Corte,Daiana Silva de Ávila,João Batista Teixeira da Rocha,Félix Alexandre Antunes Soares.  (2012-06-08)  Cooperation of non-effective concentration of glutamatergic system modulators and antioxidant against oxidative stress induced by quinolinic acid..  Neurochemical research,  37  ((9)): (1993-2003).  [PMID:22674085]
24. Valéry Combes,Gilles J Guillemin,Tailoi Chan-Ling,Nicholas H Hunt,Georges E R Grau.  (2012-06-26)  The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes..  Trends in parasitology,  28  ((8)): (311-319).  [PMID:22727810]
25. Katherine R Leaver,Aaron Reynolds,Sylvie Bodard,Denis Guilloteau,Sylvie Chalon,Michael Kassiou.  (2012-08-04)  Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum..  ACS chemical neuroscience,  ((2)): (114-119).  [PMID:22860181]
26. Pam Blundell,Michelle Symonds,Geoffrey Hall,Simon Killcross,Glynis K Bailey.  (2012-09-05)  Within-event learning in rats with lesions of the basolateral amygdala..  Behavioural brain research,  236  ((1)): (48-55).  [PMID:22944512]
27. Imad Lahdou,Mahmoud Sadeghi,Hani Oweira,Gerhard Fusch,Volker Daniel,Arianeb Mehrabi,Ge Jung,Hazem Elhadedy,Jan Schmidt,Flavius Sandra-Petrescu,Mircea Iancu,Gerhard Opelz,Peter Terness,Joerg C Schefold.  (2012-10-11)  Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis..  Human immunology,  74  ((1)): (60-66).  [PMID:23046794]
28. A L Colín-González,M Orozco-Ibarra,M E Chánez-Cárdenas,E Rangel-López,A Santamaría,J Pedraza-Chaverri,D Barrera-Oviedo,P D Maldonado.  (2012-12-04)  Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum..  Neuroscience,  231  (91-101).  [PMID:23201824]
29. Janina E Borgonovo,Mariana Troncoso,José J Lucas,Miguel A Sosa.  (2012-12-12)  Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes..  Experimental neurology,  241  (75-83).  [PMID:23219902]
30. Sawsan M S Haggag,A A M Farag,M Abdel Refea.  (2012-12-12)  Successive ion layer adsorption and reaction (SILAR) technique synthesis of Al(III)-8-hydroxy-5-nitrosoquinolate nano-sized thin films: characterization and factors optimization..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  102  (150-158).  [PMID:23220530]
31. Alessia Delli Carri,Marco Onorati,Mariah J Lelos,Valentina Castiglioni,Andrea Faedo,Ramesh Menon,Stefano Camnasio,Romina Vuono,Paolo Spaiardi,Francesca Talpo,Mauro Toselli,Gianvito Martino,Roger A Barker,Stephen B Dunnett,Gerardo Biella,Elena Cattaneo.  (2012-12-20)  Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons..  Development (Cambridge, England),  140  ((2)): (301-312).  [PMID:23250204]
32. Raffaela Silvestre Ignarro,André Schwambach Vieira,Cesar Renato Sartori,Francesco Langone,Fábio Rogério,Carlos Amilcar Parada.  (2013-02-14)  JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice..  Journal of chemical neuroanatomy,  48-49  (14-22).  [PMID:23403094]
33. Claire Tronel,Gaël Y Rochefort,Nicolas Arlicot,Sylvie Bodard,Sylvie Chalon,Daniel Antier.  (2013-03-28)  Oxidative stress is related to the deleterious effects of heme oxygenase-1 in an in vivo neuroinflammatory rat model..  Oxidative medicine and cellular longevity,  2013  (264935-264935).  [PMID:23533686]
34. Miki Terakata,Tsutomu Fukuwatari,Eri Kadota,Mitsue Sano,Masaaki Kanai,Toshikazu Nakamura,Hiroshi Funakoshi,Katsumi Shibata.  (2013-05-24)  The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase..  The Journal of nutrition,  143  ((7)): (1046-1051).  [PMID:23700344]
35. Koenraad F van der Sluijs,Marianne A van de Pol,Wim Kulik,Annemiek Dijkhuis,Barbara S Smids,Hetty W van Eijk,Jos A Karlas,Richard Molenkamp,Katja C Wolthers,Sebastian L Johnston,Jaring S van der Zee,Peter J Sterk,René Lutter.  (2013-07-25)  Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design..  Thorax,  68  ((12)): (1122-1130).  [PMID:23882022]
36. G Mazarei,D P Budac,G Lu,H Lee,T Möller,B R Leavitt.  (2013-09-03)  The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain..  Experimental neurology,  249  (144-148).  [PMID:23994717]
37. Rafael Lugo-Huitrón,Perla Ugalde Muñiz,Benjamin Pineda,José Pedraza-Chaverrí,Camilo Ríos,Verónica Pérez-de la Cruz.  (2013-10-04)  Quinolinic acid: an endogenous neurotoxin with multiple targets..  Oxidative medicine and cellular longevity,  2013  (104024-104024).  [PMID:24089628]
38. Laura Formentini,Marta P Pereira,Laura Sánchez-Cenizo,Fulvio Santacatterina,José J Lucas,Carmen Navarro,Alberto Martínez-Serrano,José M Cuezva.  (2014-02-14)  In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning..  The EMBO journal,  33  ((7)): (762-778).  [PMID:24521670]
39. Andreas Meinitzer,Andreas Tomaschitz,Stefan Pilz,Manfred Truber,Gabriele Zechner,Martin Gaksch,Barbara Prietl,Gerlies Treiber,Michaela Schwarz,Andreas Baranyi.  (2014-06-25)  Development of a liquid chromatography-mass spectrometry method for the determination of the neurotoxic quinolinic acid in human serum..  Clinica chimica acta; international journal of clinical chemistry,  436  (268-272).  [PMID:24960364]
40. Ned Sacktor,Sachiko Miyahara,Scott Evans,Giovanni Schifitto,Bruce Cohen,Norman Haughey,Julia L Drewes,David Graham,M Christine Zink,Caroline Anderson,Avindra Nath,Carlos A Pardo,Sean McCarthy,Lara Hosey,David Clifford.  (2014-11-08)  Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment..  Journal of neurovirology,  20  ((6)): (620-626).  [PMID:25377444]
41. Toshihiro Sato,Hiroaki Yamaguchi,Takuma Kogawa,Takaaki Abe,Nariyasu Mano.  (2015-01-13)  Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver..  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques,  17  ((4)): (475-484).  [PMID:25579430]
42. C Blázquez,A Chiarlone,L Bellocchio,E Resel,P Pruunsild,D García-Rincón,M Sendtner,T Timmusk,B Lutz,I Galve-Roperh,M Guzmán.  (2015-02-24)  The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway..  Cell death and differentiation,  22  ((10)): (1618-1629).  [PMID:25698444]
43. Julia L Drewes,Kelly A Meulendyke,Zhaohao Liao,Kenneth W Witwer,Lucio Gama,Ceereena Ubaida-Mohien,Ming Li,Francesca M Notarangelo,Patrick M Tarwater,Robert Schwarcz,David R Graham,M Christine Zink.  (2015-03-18)  Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART..  Journal of neurovirology,  21  ((4)): (449-463).  [PMID:25776527]
44. Sumit Jamwal,Shamsher Singh,Navneet Kaur,Puneet Kumar.  (2015-06-17)  Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism..  Neurotoxicity research,  28  ((2)): (171-184).  [PMID:26078029]
45. Yan Li,Amanda R Eskelund,Hua Zhou,David P Budac,Connie Sánchez,Maria Gulinello.  (2015-07-08)  Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE)..  International journal of molecular sciences,  16  ((7)): (15150-15171).  [PMID:26151848]
46. Federica Gaudino,Ilaria Manfredonia,Antonella Managò,Valentina Audrito,Nadia Raffaelli,Tiziana Vaisitti,Silvia Deaglio.  (2019-08-29)  Subcellular Characterization of Nicotinamide Adenine Dinucleotide Biosynthesis in Metastatic Melanoma by Using Organelle-Specific Biosensors..  Antioxidants & redox signaling,  31  ((15)): (1150-1165).  [PMID:31456414]
47. Ilona Sadok,Katarzyna Tyszczuk-Rotko,Robert Mroczka,Magdalena Staniszewska.  (2020-01-02)  Simultaneous voltammetric analysis of tryptophan and kynurenine in culture medium from human cancer cells..  Talanta,  209  (120574-120574).  [PMID:31892056]
48. K Saito,S P Markey,M P Heyes.  (1992-11-01)  Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse..  Neuroscience,  51  ((1)): (25-39).  [PMID:1465184]
49. M Ellaurie,T Calvelli,A Rubinstein.  (1992-04-01)  Neopterin concentrations in pediatric human immunodeficiency virus infection as predictor of disease activity..  The Pediatric infectious disease journal,  11  ((4)): (286-289).  [PMID:1565552]
50. M Wolfensberger,U Amsler,M Cuénod,A C Foster,W O Whetsell,R Schwarcz.  (1983-11-11)  Identification of quinolinic acid in rat and human brain tissue..  Neuroscience letters,  41  ((3)): (247-252).  [PMID:6664615]
51. A S Basile,K Saito,H al-Mardini,C O Record,R D Hughes,P Harrison,R Williams,Y Li,M P Heyes.  (1995-03-01)  The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy..  Gastroenterology,  108  ((3)): (818-823).  [PMID:7875484]
52. G M Megson,D A Stevens,J R Hamilton,D W Denning.  (1996-01-01)  D-mannitol in cerebrospinal fluid of patients with AIDS and cryptococcal meningitis..  Journal of clinical microbiology,  34  ((1)): (218-221).  [PMID:8748311]
53. D J Naisbitt,F J Vilar,A C Stalford,E G Wilkins,M Pirmohamed,B K Park.  (2001-01-12)  Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection..  AIDS research and human retroviruses,  16  ((18)): (1929-1938).  [PMID:11153075]
54. Yiquan Chen,Roger Stankovic,Karen M Cullen,Vincent Meininger,Brett Garner,Sarah Coggan,Ross Grant,Bruce J Brew,Gilles J Guillemin.  (2009-11-19)  The kynurenine pathway and inflammation in amyotrophic lateral sclerosis..  Neurotoxicity research,  18  ((2)): (132-142).  [PMID:19921535]
55. Apsara Kandanearatchi,Bruce J Brew.  (2012-01-21)  The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders..  The FEBS journal,  279  ((8)): (1366-1374).  [PMID:22260426]
56. Madhavan P N Nair,Thangavel Samikkannu.  (2012-05-18)  Differential regulation of neurotoxin in HIV clades: role of cocaine and methamphetamine..  Current HIV research,  10  ((5)): (429-434).  [PMID:22591367]
57. Charlotte R Flavell,Jonathan L C Lee.  (2012-05-23)  Post-training unilateral amygdala lesions selectively impair contextual fear memories..  Learning & memory (Cold Spring Harbor, N.Y.),  19  ((6)): (256-263).  [PMID:22615481]
58. Laszlo Vecsei,Imola Plangar,Levente Szalardy.  (2012-09-05)  Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?.  Expert review of clinical pharmacology,  ((4)): (351-353).  [PMID:22943114]
59. Miki Terakata,Tsutomu Fukuwatari,Mitsue Sano,Natsuki Nakao,Ryuzo Sasaki,Shin-Ichi Fukuoka,Katsumi Shibata.  (2012-10-26)  Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice..  The Journal of nutrition,  142  ((12)): (2148-2153).  [PMID:23096007]
60. Guozan Yuan,Yanping Huo,Xiaoli Nie,Hong Jiang,Bin Liu,Xiaoming Fang,Fenghua Zhao.  (2012-12-18)  Controllable supramolecular structures and luminescent properties of unique trimeric Zn(II) 8-hydroxyquinolinates tuned by functional substituents..  Dalton transactions (Cambridge, England : 2003),  42  ((8)): (2921-2929).  [PMID:23243665]
61. Sophie Erhardt,Chai K Lim,Klas R Linderholm,Shorena Janelidze,Daniel Lindqvist,Martin Samuelsson,Kristina Lundberg,Teodor T Postolache,Lil Träskman-Bendz,Gilles J Guillemin,Lena Brundin.  (2013-01-10)  Connecting inflammation with glutamate agonism in suicidality..  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,  38  ((5)): (743-752).  [PMID:23299933]
62. Katsumi Shibata,Rina Kondo,Mitsue Sano,Tsutomu Fukuwatari.  (2013-02-09)  Increased conversion of tryptophan to nicotinamide in rats by dietary valproate..  Bioscience, biotechnology, and biochemistry,  77  ((2)): (295-300).  [PMID:23391917]
63. Terri L Petkau,Shanshan Zhu,Ge Lu,Sarah Fernando,Max Cynader,Blair R Leavitt.  (2013-05-25)  Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice..  Neurobiology of aging,  34  ((11)): (2548-2550).  [PMID:23702345]
64. Gelareh Mazarei,David P Budac,Ge Lu,Hans Adomat,Emma S Tomlinson Guns,Thomas Möller,Blair R Leavitt.  (2013-06-22)  Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease..  Journal of neurochemistry,  127  ((6)): (852-867).  [PMID:23786539]
65. Gian Paolo Vallerini,Laura Amori,Claudia Beato,Margarita Tararina,Xiao-Dan Wang,Robert Schwarcz,Gabriele Costantino.  (2013-11-28)  2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents..  Journal of medicinal chemistry,  56  ((23)): (9482-9495).  [PMID:24274468]
66. Paula Pierozan,Fernanda Ferreira,Bárbara Ortiz de Lima,Carolina Gonçalves Fernandes,Priscila Totarelli Monteforte,Natalia de Castro Medaglia,Claudia Bincoletto,Soraya Soubhi Smaili,Regina Pessoa-Pureur.  (2014-03-04)  The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid..  Experimental cell research,  322  ((2)): (313-323).  [PMID:24583400]
67. .  ()  Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats..      [PMID:24976581]
68. Naiani Ferreira Marques,Sílvio Terra Stefanello,Amanda L F Froeder,Alcindo Busanello,Aline Augusti Boligon,Margareth Linde Athayde,Félix A A Soares,Roselei Fachinetto.  (2015-04-24)  Centella asiatica and Its Fractions Reduces Lipid Peroxidation Induced by Quinolinic Acid and Sodium Nitroprusside in Rat Brain Regions..  Neurochemical research,  40  ((6)): (1197-1210).  [PMID:25903808]
69. Cemile Yılmaz,Vural Gökmen.  (2017-11-18)  Determination of tryptophan derivatives in kynurenine pathway in fermented foods using liquid chromatography tandem mass spectrometry..  Food chemistry,  243  (420-427).  [PMID:29146359]
70. Jessica Huyet,Mohammad Ozeir,Marie-Claude Burgevin,Benoît Pinson,Françoise Chesney,Jean-Marc Remy,Abdul Rauf Siddiqi,Roland Lupoli,Gregory Pinon,Christelle Saint-Marc,Jean-Francois Gibert,Renaud Morales,Irène Ceballos-Picot,Robert Barouki,Bertrand Daignan-Fornier,Anne Olivier-Bandini,Franck Augé,Pierre Nioche.  (2018-03-27)  Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase..  Cell chemical biology,  25  ((6)): (666-676).  [PMID:29576532]
71. Huilin Li, Jingying Yang, Xiaochun Hu, Ran Han, Shuo Wang, Mingfei Pan.  (2023)  Portable smartphone-assisted fluorescence-colorimetric multidimensional immunosensing microarray based on NH2-UiO-66@PtNPs multifunctional composite for efficient and visual detection of amantadine.  CHEMICAL ENGINEERING JOURNAL,  473  (145401).  [PMID:] [10.1016/j.cej.2023.145401]
72. Yakun Sun, Long Li, Xinxu Li, Ya-Nan Feng, Fei-Fei Chen, Lingyun Li, Yan Yu.  (2023)  Regulating Activity and Selectivity of Photocatalytic CO2 Reduction on Cobalt by Rare Earth Compounds.  ACS Applied Materials & Interfaces,  15  (13): (16621–16630).  [PMID:36949018] [10.1021/acsami.2c20402]
73. Nan Jiang, Hongyan Liu, Guodong Zhao, Heyi Li, Shuo Yang, Xianlin Xu, Xupin Zhuang, Bowen Cheng.  (2023)  Aramid nanofibers supported metal-organic framework aerogel for protection of chemical warfare agent.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  640  (192).  [PMID:36863176] [10.1016/j.jcis.2023.02.105]
74. Shengnan Yin, Changlun Tong.  (2021)  Europium(III)-Modified Silver Nanoparticles as Ratiometric Colorimetric and Fluorescent Dual-Mode Probes for Selective Detection of Dipicolinic Acid in Bacterial Spores and Lake Waters.  ACS Applied Nano Materials,  (5): (5469–5477).  [PMID:] [10.1021/acsanm.1c00838]
75. Ru-Ru Gao, Wei Dong.  (2021)  ATP and lanthanide ions derived coordination polymer nanoparticles as a novel family of versatile materials: Color-tunable emission, artificial tongues and logic devices.  MICROCHEMICAL JOURNAL,  160  (105753).  [PMID:] [10.1016/j.microc.2020.105753]
76. Hao Chen, Chunlong Dai, Yanan Li, Renming Zhan, Min-Qiang Wang, Bingshu Guo, Youquan Zhang, Heng Liu, Maowen Xu, Shu-juan Bao.  (2018)  An excellent full sodium-ion capacitor derived from a single Ti-based metal–organic framework.  Journal of Materials Chemistry A,  (48): (24860-24868).  [PMID:] [10.1039/C8TA09072F]
77. Shi-Fan Xue, Jing-Fei Zhang, Zi-Han Chen, Xin-Yue Han, Min Zhang, Guoyue Shi.  (2018)  Multifunctional fluorescent sensing of chemical and physical stimuli using smart riboflavin-5′-phosphate/Eu3+ coordination polymers.  ANALYTICA CHIMICA ACTA,  1012  (74).  [PMID:29475476] [10.1016/j.aca.2018.01.038]
78. Qi-Xian Wang, Shi-Fan Xue, Zi-Han Chen, Shi-Hui Ma, Shengqiang Zhang, Guoyue Shi, Min Zhang.  (2017)  Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor.  BIOSENSORS & BIOELECTRONICS,  94  (388).  [PMID:28324858] [10.1016/j.bios.2017.03.027]

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