Basic Description

Synonyms	quinolinic acid \| Pyridine-2,3-dicarboxylic acid \| 89-00-9 \| 2,3-pyridinedicarboxylic acid \| quinolinate \| 339155-13-4 \| Pyridine-2,3-dicarboxylate \| pyridinedicarboxylic acid \| AI3-63017 \| C7H5NO4 \| pyridine-2,3-carboxylate \| MFCD00006295 \| F6F0HK1URN \| CHEMBL286204 \| DTXSID8041327
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	A matabolite of tryptophan and a putative NMDA receptor agonist.

Associated Targets(Human)

AGER Tchem Advanced glycosylation end product-specific receptor (1 Activities)

Discover Target: AGER

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

Discover Target: ALOX5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARSA Tbio Cerebroside-sulfatase (655 Activities)

Discover Target: ARSA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

Discover Target: MMP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

Discover Target: MMP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

Discover Target: MMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIN2C Tclin Glutamate [NMDA] receptor subunit epsilon 3 (47 Activities)

Discover Target: GRIN2C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)

Discover Target: L3MBTL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)

Discover Target: RUNX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGER Tchem Advanced glycosylation end product-specific receptor (291 Activities)

Discover Target: AGER

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

blaZ Beta-lactamase (285 Activities)

Discover Target: blaZ

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nos2 Nitric oxide synthase, inducible (3573 Activities)

Discover Target: Nos2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lef Anthrax lethal factor (7585 Activities)

Discover Target: lef

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Beta-lactamase L1 (242 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Npsr1 Neuropeptide S receptor (260 Activities)

Discover Target: Npsr1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 Activities)

Discover Target: Grin1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gria2 Glutamate receptor ionotropic, AMPA (2103 Activities)

Discover Target: Gria2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

blaIMP-1 Metallo beta-lactamase (43 Activities)

Discover Target: blaIMP-1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	pyridine-2,3-dicarboxylic acid
INCHI	InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChi Key	GJAWHXHKYYXBSV-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(N=C1)C(=O)O)C(=O)O
Isomeric SMILES	C1=CC(=C(N=C1)C(=O)O)C(=O)O
WGK Germany	3
RTECS	US7967250
Alternate CAS	339155-13-4
PubChem CID	1066
Molecular Weight	167.12
Beilstein	137110
Reaxy-Rn	137110

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Melt Point(°C)	188-190°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	US7967250
Reaxy-Rn	137110
Merck Index	8073

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Huilin Li, Jingying Yang, Xiaochun Hu, Ran Han, Shuo Wang, Mingfei Pan. (2023) Portable smartphone-assisted fluorescence-colorimetric multidimensional immunosensing microarray based on NH2-UiO-66@PtNPs multifunctional composite for efficient and visual detection of amantadine. CHEMICAL ENGINEERING JOURNAL, 473 (145401). [PMID:] [10.1016/j.cej.2023.145401]
2. Yakun Sun, Long Li, Xinxu Li, Ya-Nan Feng, Fei-Fei Chen, Lingyun Li, Yan Yu. (2023) Regulating Activity and Selectivity of Photocatalytic CO2 Reduction on Cobalt by Rare Earth Compounds. ACS Applied Materials & Interfaces, 15 (13): (16621–16630). [PMID:36949018] [10.1021/acsami.2c20402]
3. Nan Jiang, Hongyan Liu, Guodong Zhao, Heyi Li, Shuo Yang, Xianlin Xu, Xupin Zhuang, Bowen Cheng. (2023) Aramid nanofibers supported metal-organic framework aerogel for protection of chemical warfare agent. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 640 (192). [PMID:36863176] [10.1016/j.jcis.2023.02.105]
4. Shengnan Yin, Changlun Tong. (2021) Europium(III)-Modified Silver Nanoparticles as Ratiometric Colorimetric and Fluorescent Dual-Mode Probes for Selective Detection of Dipicolinic Acid in Bacterial Spores and Lake Waters. ACS Applied Nano Materials, 4 (5): (5469–5477). [PMID:] [10.1021/acsanm.1c00838]
5. Ru-Ru Gao, Wei Dong. (2021) ATP and lanthanide ions derived coordination polymer nanoparticles as a novel family of versatile materials: Color-tunable emission, artificial tongues and logic devices. MICROCHEMICAL JOURNAL, 160 (105753). [PMID:] [10.1016/j.microc.2020.105753]
6. Hao Chen, Chunlong Dai, Yanan Li, Renming Zhan, Min-Qiang Wang, Bingshu Guo, Youquan Zhang, Heng Liu, Maowen Xu, Shu-juan Bao. (2018) An excellent full sodium-ion capacitor derived from a single Ti-based metal–organic framework. Journal of Materials Chemistry A, 6 (48): (24860-24868). [PMID:] [10.1039/C8TA09072F]
7. Shi-Fan Xue, Jing-Fei Zhang, Zi-Han Chen, Xin-Yue Han, Min Zhang, Guoyue Shi. (2018) Multifunctional fluorescent sensing of chemical and physical stimuli using smart riboflavin-5′-phosphate/Eu3+ coordination polymers. ANALYTICA CHIMICA ACTA, 1012 (74). [PMID:29475476] [10.1016/j.aca.2018.01.038]
8. Qi-Xian Wang, Shi-Fan Xue, Zi-Han Chen, Shi-Hui Ma, Shengqiang Zhang, Guoyue Shi, Min Zhang. (2017) Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor. BIOSENSORS & BIOELECTRONICS, 94 (388). [PMID:28324858] [10.1016/j.bios.2017.03.027]

References

1. Huilin Li, Jingying Yang, Xiaochun Hu, Ran Han, Shuo Wang, Mingfei Pan. (2023) Portable smartphone-assisted fluorescence-colorimetric multidimensional immunosensing microarray based on NH2-UiO-66@PtNPs multifunctional composite for efficient and visual detection of amantadine. CHEMICAL ENGINEERING JOURNAL, 473 (145401). [PMID:] [10.1016/j.cej.2023.145401]
2. Yakun Sun, Long Li, Xinxu Li, Ya-Nan Feng, Fei-Fei Chen, Lingyun Li, Yan Yu. (2023) Regulating Activity and Selectivity of Photocatalytic CO2 Reduction on Cobalt by Rare Earth Compounds. ACS Applied Materials & Interfaces, 15 (13): (16621–16630). [PMID:36949018] [10.1021/acsami.2c20402]
3. Nan Jiang, Hongyan Liu, Guodong Zhao, Heyi Li, Shuo Yang, Xianlin Xu, Xupin Zhuang, Bowen Cheng. (2023) Aramid nanofibers supported metal-organic framework aerogel for protection of chemical warfare agent. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 640 (192). [PMID:36863176] [10.1016/j.jcis.2023.02.105]
4. Shengnan Yin, Changlun Tong. (2021) Europium(III)-Modified Silver Nanoparticles as Ratiometric Colorimetric and Fluorescent Dual-Mode Probes for Selective Detection of Dipicolinic Acid in Bacterial Spores and Lake Waters. ACS Applied Nano Materials, 4 (5): (5469–5477). [PMID:] [10.1021/acsanm.1c00838]
5. Ru-Ru Gao, Wei Dong. (2021) ATP and lanthanide ions derived coordination polymer nanoparticles as a novel family of versatile materials: Color-tunable emission, artificial tongues and logic devices. MICROCHEMICAL JOURNAL, 160 (105753). [PMID:] [10.1016/j.microc.2020.105753]
6. Hao Chen, Chunlong Dai, Yanan Li, Renming Zhan, Min-Qiang Wang, Bingshu Guo, Youquan Zhang, Heng Liu, Maowen Xu, Shu-juan Bao. (2018) An excellent full sodium-ion capacitor derived from a single Ti-based metal–organic framework. Journal of Materials Chemistry A, 6 (48): (24860-24868). [PMID:] [10.1039/C8TA09072F]
7. Shi-Fan Xue, Jing-Fei Zhang, Zi-Han Chen, Xin-Yue Han, Min Zhang, Guoyue Shi. (2018) Multifunctional fluorescent sensing of chemical and physical stimuli using smart riboflavin-5′-phosphate/Eu3+ coordination polymers. ANALYTICA CHIMICA ACTA, 1012 (74). [PMID:29475476] [10.1016/j.aca.2018.01.038]
8. Qi-Xian Wang, Shi-Fan Xue, Zi-Han Chen, Shi-Hui Ma, Shengqiang Zhang, Guoyue Shi, Min Zhang. (2017) Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor. BIOSENSORS & BIOELECTRONICS, 94 (388). [PMID:28324858] [10.1016/j.bios.2017.03.027]

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2,3-Pyridinedicarboxylic acid - 10mM in DMSO, high purity , CAS No.89-00-9

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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