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2.6.1.42 Branched-chain-amino-acid transaminase
2-[4-(1H-pyrazol-3-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-one , CAS No.H609227, Inhibitor of branched chain amino acid transaminase 2

2-[4-(1H-pyrazol-3-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-one , CAS No.H609227, Inhibitor of branched chain amino acid transaminase 2

Item Number

H609227

Grouped product items
SKU	Size	Availability	Price	Qty
H609227-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
H609227-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of branched chain amino acid transaminase 2

BCAT2 Tchem Branched-chain-amino-acid aminotransferase, mitochondrial (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	2-[4-(1H-pyrazol-3-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-one
INCHI	InChI=1S/C18H15N3O/c22-18-16-4-2-1-3-13(16)10-12-21(18)15-7-5-14(6-8-15)17-9-11-19-20-17/h1-9,11H,10,12H2,(H,19,20)
InChi Key	NEEFLDGZGNPYSN-UHFFFAOYSA-N
Canonical SMILES	O=C1N(CCc2c1cccc2)c1ccc(cc1)c1cc[nH]n1
Isomeric SMILES	C1CN(C(=O)C2=CC=CC=C21)C3=CC=C(C=C3)C4=CC=NN4
PubChem CID	121231397

PubChem CID	121231397

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1. Borthwick JA, Ancellin N, Bertrand SM, Bingham RP, Carter PS, Chung CW, Churcher I, Dodic N, Fournier C, Francis PL et al.. (2016) Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.. J Med Chem, 59 (6): (2452-67). [PMID:26938474] [10.1021/op500134e]

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