2,4,3′,5′-tetramethoxystilbene - 98% (HPLC), high purity , CAS No.24144-92-1

4 Citations
  • ≥98%(HPLC)
Item Number
t168933
Grouped product items
SKUSizeAvailabilityPrice Qty
t168933-10mg
10mg
In stock
$94.90
t168933-50mg
50mg
In stock
$355.90
T168933-250mg
250mg
In stock
$1,602.90
T168933-1g
1g
In stock
$5,767.90

Potent, selective CYP1B1 inhibitor

Basic Description

Synonyms24144-92-1 | tms | 2,3',4,5'-tetramethoxystilbene | (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene | 20578-92-1 | 2,4,3',5'-tetramethoxystilbene | (E)-2,3',4,5'-tetramethoxystilbene | CHEMBL46909 | 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxybenzene | Benzene, 1
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsPotent, selective CYP1B1 inhibitor (IC 50 values are 6, 300 and 3100 nM for 1B1, 1A1 and 1A2, respectively). Competitive inhibitor (K i = 3 nM). Anticancer activity in vitro . 2,3′,4,5′-Tetramethoxystilbene, also known as TMS, is a selective and competiti
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CYP1B1 Tchem Cytochrome P450 1B1 (7 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP1A1 Tchem Cytochrome P450 1A1 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Col2 (437 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK3 Tchem Mitogen-activated protein kinase; ERK1/ERK2 (651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549/TR (299 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene
INCHI InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
InChi Key JDBCWSHYEQUBLW-AATRIKPKSA-N
Canonical SMILES COC1=CC(=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC)OC
Isomeric SMILES COC1=CC(=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)OC
PubChem CID 5354004
Molecular Weight 300.35

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
I2205259Certificate of AnalysisJun 25, 2022 t168933
I2205262Certificate of AnalysisJun 25, 2022 t168933
I2205425Certificate of AnalysisJun 25, 2022 t168933
I2205426Certificate of AnalysisJun 25, 2022 t168933

Related Documents

Citations of This Product

1. Zhixiang Hu, Licheng Zhou, Long Li, Jingyao Liu, Hua-Yao Li, Boxiang Song, Jianbing Zhang, Jiang Tang, Huan Liu.  (2023)  Stabilization of PbS colloidal-quantum-dot gas sensors using atomic-ligand engineering.  SENSORS AND ACTUATORS B-CHEMICAL,  388  (133850).  [PMID:]
2. Xiaodie Deng, Jialin Li, Pengbin Lai, Silan Kuang, Jiaxiang Liu, Pengpeng Dai, Haiming Hua, Peng Dong, Yingjie Zhang, Yang Yang, Jinbao Zhao.  (2023)  Tailored interface composition improves the integrity of electrode/electrolyte interphases for high-voltage Ni-rich lithium metal batteries in a sulfolane-based electrolyte.  CHEMICAL ENGINEERING JOURNAL,  465  (142907).  [PMID:]
3. Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen-Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai-Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li, Jun Xu.  (2022)  Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (39): (12577–12586).  [PMID:36130944]
4. Junjun Yin, Xiaoqian Chen, Duo Wang.  (2022)  Purification of creosol applying green heterogeneous extraction technology.  JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,  97  (10): (2945-2951).  [PMID:]

References

1. Rentas S et al..  (2016)  Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells..  Nature,  532  (7600): (508-511).  [PMID:27121842]
2. Zhixiang Hu, Licheng Zhou, Long Li, Jingyao Liu, Hua-Yao Li, Boxiang Song, Jianbing Zhang, Jiang Tang, Huan Liu.  (2023)  Stabilization of PbS colloidal-quantum-dot gas sensors using atomic-ligand engineering.  SENSORS AND ACTUATORS B-CHEMICAL,  388  (133850).  [PMID:]
3. Xiaodie Deng, Jialin Li, Pengbin Lai, Silan Kuang, Jiaxiang Liu, Pengpeng Dai, Haiming Hua, Peng Dong, Yingjie Zhang, Yang Yang, Jinbao Zhao.  (2023)  Tailored interface composition improves the integrity of electrode/electrolyte interphases for high-voltage Ni-rich lithium metal batteries in a sulfolane-based electrolyte.  CHEMICAL ENGINEERING JOURNAL,  465  (142907).  [PMID:]
4. Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen-Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai-Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li, Jun Xu.  (2022)  Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (39): (12577–12586).  [PMID:36130944]
5. Junjun Yin, Xiaoqian Chen, Duo Wang.  (2022)  Purification of creosol applying green heterogeneous extraction technology.  JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,  97  (10): (2945-2951).  [PMID:]

Solution Calculators