2,4'-Dibromoacetophenone - 98%, high purity , CAS No.99-73-0

Item Number

D113568

• Synonyms: 2,4'-Dibromoacetophenone, >98% | STL069069 | 2,4'-Dibromoacetophenone, for HPLC derivatization, >=99.0% (HPLC) | .alpha.,para-Dibromoacetophenone | 2,4'-dibromo acetophenone | Halomethyl Phenyl Ketone deriv. 24 | 4-BPB | BP-20195 | CCRIS 3623 | MFCD000002
• Specifications & Purity: ≥98%
• Storage Temp: Store at 2-8°C,Protected from light
• Shipped In: Wet ice

Product Description

GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.
A cell-permeable, and non-ATP competitive inhibitor of GSK-3β

Application：

Undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.