JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Applications
Targets
Other protein targets
Cytolytic pore-forming proteins
2,4-difluoro-N-[2-methoxy-5-[5-(6-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-3-yl)thiophen-2-yl]pyridin-3-yl]benzenesulfonamide , CAS No.D608777, Inhibitor of perforin 1

Skip to the end of the images gallery

Skip to the beginning of the images gallery

2,4-difluoro-N-[2-methoxy-5-[5-(6-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-3-yl)thiophen-2-yl]pyridin-3-yl]benzenesulfonamide , CAS No.D608777, Inhibitor of perforin 1

Moligand™

PubChem CID: 139269773

Item Number

D608777

Grouped product items
SKU	Size	Availability	Price	Qty
D608777-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D608777-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

perforin 1 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of perforin 1

Associated Targets(Human)

PRF1 Tchem Perforin-1 (0 Activities)

Discover Target: PRF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

INCHI	InChI=1S/C24H18F2N4O4S2/c1-30-12-15-7-13(10-27-22(15)24(30)31)19-4-5-20(35-19)14-8-18(23(34-2)28-11-14)29-36(32,33)21-6-3-16(25)9-17(21)26/h3-11,29H,12H2,1-2H3
InChi Key	ZYYGNLSPUWSHQW-UHFFFAOYSA-N
Canonical SMILES	COc1ncc(cc1NS(=O)(=O)c1ccc(cc1F)F)c1ccc(s1)c1cnc2c(c1)CN(C2=O)C
Isomeric SMILES	CN1CC2=C(C1=O)N=CC(=C2)C3=CC=C(S3)C4=CC(=C(N=C4)OC)NS(=O)(=O)C5=C(C=C(C=C5)F)F
PubChem CID	139269773

Database links

PubChem CID	139269773

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS. (2007) NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism.. Am J Transplant, 7 (8): (1884-96). [PMID:17617852] [10.1021/op500134e]
2. Villard J. (2011) The role of natural killer cells in human solid organ and tissue transplantation.. J Innate Immun, 3 (4): (395-402). [PMID:21411978] [10.1021/op500134e]
3. Spicer JA, Miller CK, O'Connor PD, Jose J, Giddens AC, Jaiswal JK, Jamieson SMF, Bull MR, Denny WA, Akhlaghi H et al.. (2020) Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.. J Med Chem, 63 (5): (2229-2239). [PMID:31525966] [10.1021/op500134e]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.