Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | Pyridine-2,4-dicarboxylic acid | 499-80-9 | 2,4-PYRIDINEDICARBOXYLIC ACID | Lutidinic acid | 2,4-PDCA | 2,4-Lutidinic acid | AFI29F0TVL | CHEBI:44737 | NSC-403248 | 108882-06-0 | 4nrq | EC 207-892-2 | PD2 | EINECS 207-892-2 | NSC 403248 | 2,4-Dicarboxypyridine | 4-carboxypicolinic acid | |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | 2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target. |
Associated Targets(Human)
EGLN1 Tclin Egl nine homolog 1 (1 Activities)
KDM4C Tchem Lysine-specific demethylase 4C (4 Activities)
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KDM5A Tchem Lysine-specific demethylase 5A (1 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KDM5C Tchem Lysine-specific demethylase 5C (1 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ASPH Tchem Aspartyl/asparaginyl beta-hydroxylase (4 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KDM4A Tchem Lysine-specific demethylase 4A (2 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KDM4E Tchem Lysine-specific demethylase 4E (1 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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EGLN2 Tclin Hypoxia-inducible factor prolyl hydroxylase 1 (404 Activities)
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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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A549 (127892 Activities)
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LNCaP (8286 Activities)
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HeLa (62764 Activities)
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POLI Tchem DNA polymerase iota (116820 Activities)
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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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EGLN1 Tclin Egl nine homolog 1 (1702 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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EGLN3 Tclin Egl nine homolog 3 (250 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HIF1AN Tbio Hypoxia-inducible factor 1-alpha inhibitor (79 Activities)
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KDM4D Tchem Lysine-specific demethylase 4D (224 Activities)
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KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)
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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
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KDM3A Tchem Lysine-specific demethylase 3A (116 Activities)
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KDM2A Tchem Lysine-specific demethylase 2A (198 Activities)
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KDM6B Tchem Lysine-specific demethylase 6B (280 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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PHF8 Tchem Histone lysine demethylase PHF8 (151 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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KDM6A Tchem Lysine-specific demethylase 6A (39 Activities)
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BBOX1 Tchem Gamma-butyrobetaine dioxygenase (162 Activities)
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KDM5C Tchem Lysine-specific demethylase 5C (224 Activities)
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KDM7A Tchem Lysine-specific demethylase 7 (35 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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FTO Tchem Alpha-ketoglutarate-dependent dioxygenase FTO (473 Activities)
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KDM5A Tchem Lysine-specific demethylase 5A (893 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ALKBH5 Tchem RNA demethylase ALKBH5 (134 Activities)
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KDM5B Tchem Lysine-specific demethylase 5B (814 Activities)
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ASPH Tchem Aspartyl/asparaginyl beta-hydroxylase (62 Activities)
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Associated Targets(non-human)
blaZ Beta-lactamase (285 Activities)
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Slc17a1 Renal sodium-dependent phosphate transport protein 1 (33 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Plasmodium falciparum (966862 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Beta-lactamase L1 (242 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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rep Replicase polyprotein 1ab (378 Activities)
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Mapt Microtubule-associated protein tau (6 Activities)
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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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blaIMP-1 Metallo beta-lactamase (43 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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REL1 RNA-editing ligase 1, mitochondrial (130 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SARS-CoV-2 (38078 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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A085R Prolyl 4-hydroxylase (72 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Names and Identifiers
| IUPAC Name | pyridine-2,4-dicarboxylic acid |
|---|---|
| INCHI | InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12) |
| InChi Key | MJIVRKPEXXHNJT-UHFFFAOYSA-N |
| Canonical SMILES | C1=CN=C(C=C1C(=O)O)C(=O)O |
| Isomeric SMILES | C1=CN=C(C=C1C(=O)O)C(=O)O |
| WGK Germany | 3 |
| Alternate CAS | 207671-42-9 |
| PubChem CID | 10365 |
| Molecular Weight | 167.12 |
| Beilstein | 131631 |
| Reaxy-Rn | 131631 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Sensitivity | Hygroscopic |
|---|---|
| Melt Point(°C) | 243-246°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 131631 |