Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C609018-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,334.90 | |
C609018-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,000.90 |
Specifications & Purity | Moligand™ |
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Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of serine/threonine kinase 16;Inhibitor of Serine/threonine kinase 38 like |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | Expert: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
IUPAC Name | 2-[[5-chloro-2-[(1-ethyl-5,5-dimethyl-2-oxo-3,4-dihydro-1-benzazepin-8-yl)amino]pyrimidin-4-yl]amino]-3-fluoro-N-methylbenzamide |
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INCHI | InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33) |
InChi Key | KHBUKOVUBUJCGM-UHFFFAOYSA-N |
Canonical SMILES | CNC(=O)c1cccc(c1Nc1nc(ncc1Cl)Nc1ccc2c(c1)N(CC)C(=O)CCC2(C)C)F |
Isomeric SMILES | CCN1C(=O)CCC(C2=C1C=C(C=C2)NC3=NC=C(C(=N3)NC4=C(C=CC=C4F)C(=O)NC)Cl)(C)C |
PubChem CID | 50942314 |
1. Weinberg LR, Albom MS, Angeles TS, Husten J, Lisko JG, McHugh RJ, Milkiewicz KL, Murthy S, Ott GR, Theroff JP et al.. (2011) Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors.. Bioorg Med Chem Lett, 21 (1): (164-7). [PMID:21123062] [10.1021/op500134e] |