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D426685-1ml

1ml

Available within 8-12 weeks(?)

$29.90

Basic Description

Synonyms	2,5-Di-tert-butylhydroquinone \| 88-58-4 \| 2,5-Di-tert-butylbenzene-1,4-diol \| DTBHQ \| Dibug \| Dybug \| Santovar O \| 2,5-Di-tert-butylquinol \| Di-t-butylhydroquinone \| bhq \| 2,5-Di-t-butylhydroquinone \| Naugard 451 \| Nonflex Alba \| Antage DBH \| 1,4-Benzenediol, 2,5-bis(1,1-dimethyleth
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Inhibiting the sarcoplasmic reticulum (SR) Ca2+ uptake in the rat ventricle.Sarco-endoplasmic reticulum Ca 2+ ATPase (SERCA) inhibitor
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts.2,5-Di-tert-butylhydroquinone (DBHQ) has been shown to be a selective and potent inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which is shown to cause induction of Ca2+ release from agonist-insensitive and agonist-sensitive intracellular stores. In isolated rat hepatocyte studies, DBHQ was reported to induce a rapid increase in cytosolic Ca2+ concentration without loss of other microsomal enzyme activity, altering membrane permeability, or modification of microsomal protein thiols.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC4 Tchem Short transient receptor potential channel 4 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSPA5 Tchem Endoplasmic reticulum chaperone BiP (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATP2A3 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATP2A2 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATP2A1 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATP2A3 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (6 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATP2A2 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (53 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lef Anthrax lethal factor (7585 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATP2A1 Sarcoplasmic/endoplasmic reticulum calcium ATP-ase (121 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpc4 Short transient receptor potential channel 4 (1615 Activities)

Discover Target: Trpc4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2,5-ditert-butylbenzene-1,4-diol
INCHI	InChI=1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3
InChi Key	JZODKRWQWUWGCD-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC(=C(C=C1O)C(C)(C)C)O
Isomeric SMILES	CC(C)(C)C1=CC(=C(C=C1O)C(C)(C)C)O
WGK Germany	3
RTECS	MX5160000
PubChem CID	2374
Molecular Weight	222.32
Beilstein	2049542
Reaxy-Rn	2049542

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Light & Air sensitive
Flash Point(°F)	392°F
Flash Point(°C)	>200°C
Boil Point(°C)	321°C
Melt Point(°C)	214-222°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09
Signal	Danger
Hazard Statements	H335:May cause respiratory irritation H301:Toxic if swallowed H317:May cause an allergic skin reaction H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P302+P352:IF ON SKIN: wash with plenty of water. P264:Wash hands [and …] thoroughly after handling.
WGK Germany	3
RTECS	MX5160000
Reaxy-Rn	2049542

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hao Wang, Naihang Kuang, Ziqiao Wang, Yanzhi Wang, Zidie Song, Chunhua Zhang. (2023) A coupling strategy for excellent mechanical properties and enhanced interfacial performance of polyimide/carbon fiber composite with metal-free catalyzed-curing route. COMPOSITES SCIENCE AND TECHNOLOGY, 242 (110188). [PMID:] [10.1016/j.compscitech.2023.110188]
2. Feihong Zhang, Jun Li, Shuping Yang, Yanlan Bi. (2021) Inhibitory effect of antioxidants on biodiesel crystallization: Revealing the role of antioxidants. FUEL, 297 (120782). [PMID:] [10.1016/j.fuel.2021.120782]
3. Limei Fan, Qingqing Hao, Xianwen Kan. (2018) Three-dimensional graphite paper based imprinted electrochemical sensor for tertiary butylhydroquinone selective recognition and sensitive detection. SENSORS AND ACTUATORS B-CHEMICAL, 256 (520). [PMID:] [10.1016/j.snb.2017.10.085]
4. Yijian Wu, Baoqing Shentu, Zhixue Weng. (2016) Synergistic effect of SBS and trimethylopropane trimethacrylate (TMPTMA) on dynamically vulcanized SEBS/PP blends. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (5): [PMID:] [10.1002/app.44392]

References

1. Hao Wang, Naihang Kuang, Ziqiao Wang, Yanzhi Wang, Zidie Song, Chunhua Zhang. (2023) A coupling strategy for excellent mechanical properties and enhanced interfacial performance of polyimide/carbon fiber composite with metal-free catalyzed-curing route. COMPOSITES SCIENCE AND TECHNOLOGY, 242 (110188). [PMID:] [10.1016/j.compscitech.2023.110188]
2. Feihong Zhang, Jun Li, Shuping Yang, Yanlan Bi. (2021) Inhibitory effect of antioxidants on biodiesel crystallization: Revealing the role of antioxidants. FUEL, 297 (120782). [PMID:] [10.1016/j.fuel.2021.120782]
3. Limei Fan, Qingqing Hao, Xianwen Kan. (2018) Three-dimensional graphite paper based imprinted electrochemical sensor for tertiary butylhydroquinone selective recognition and sensitive detection. SENSORS AND ACTUATORS B-CHEMICAL, 256 (520). [PMID:] [10.1016/j.snb.2017.10.085]
4. Yijian Wu, Baoqing Shentu, Zhixue Weng. (2016) Synergistic effect of SBS and trimethylopropane trimethacrylate (TMPTMA) on dynamically vulcanized SEBS/PP blends. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (5): [PMID:] [10.1002/app.44392]

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2,5-Di-tert-butylhydroquinone (DBHQ) - 10mM in DMSO, high purity , CAS No.88-58-4