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2,6-difluoro-N-[2-fluoro-5-[5-[2-[(6-morpholin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]-2-propan-2-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide , CAS No.D609009, Inhibitor of nuclear receptor coactivator 1

  • Moligand™
Item Number
D609009
Grouped product items
SKUSizeAvailabilityPrice Qty
D609009-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609009-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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nuclear receptor coactivator 1 Inhibitor

Basic Description

SynonymsExample 23 [WO2010104899A1];compound 26
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of nuclear receptor coactivator 1

Associated Targets

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TGFBR1 Tchem TGF-beta receptor type-1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LCK Tclin Tyrosine-protein kinase Lck 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LYN Tclin Tyrosine-protein kinase Lyn 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRAF Tclin Serine/threonine-protein kinase B-raf 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACVR2B Tchem Activin receptor type-2B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NCOA1 Tchem Nuclear receptor coactivator 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2,6-difluoro-N-[2-fluoro-5-[5-[2-[(6-morpholin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]-2-propan-2-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide
INCHI InChI=1S/C31H28F3N7O3S2/c1-18(2)30-39-27(19-6-8-21(32)25(16-19)40-46(42,43)29-22(33)4-3-5-23(29)34)28(45-30)24-10-11-35-31(38-24)37-20-7-9-26(36-17-20)41-12-14-44-15-13-41/h3-11,16-18,40H,12-15H2,1-2H3,(H,35,37,38)
InChi Key KJUCPVIVNLPLEE-UHFFFAOYSA-N
Canonical SMILES CC(c1sc(c(n1)c1ccc(c(c1)NS(=O)(=O)c1c(F)cccc1F)F)c1ccnc(n1)Nc1ccc(nc1)N1CCOCC1)C
Isomeric SMILES CC(C)C1=NC(=C(S1)C2=NC(=NC=C2)NC3=CN=C(C=C3)N4CCOCC4)C5=CC(=C(C=C5)F)NS(=O)(=O)C6=C(C=CC=C6F)F
PubChem CID 46927672

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Stellwagen JC, Adjabeng GM, Arnone MR, Dickerson SH, Han C, Hornberger KR, King AJ, Mook Jr RA, Petrov KG, Rheault TR et al..  (2011)  Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup..  Bioorg Med Chem Lett,  21  (15): (4436-40).  [PMID:21733693]

Solution Calculators

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