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2,6-Dimethylaniline - 99%, high purity , CAS No.87-62-7

9 Citations

≥99%

CAS#: 87-62-7
Formula: C₈H₁₁N
Molecular Weight: 121.18
Beilstein Registry Number: 121107
MDL number: MFCD00007747
PubChem CID: 6896
PubChem SID: 488180194

Item Number

D105633

Grouped product items
SKU	Size	Availability	Price
D105633-25ml	25ml	In stock	$17.90
D105633-100ml	100ml	In stock	$61.90
D105633-500ml	500ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$277.90

View related series

Nitrogenous compounds Non heterocyclic block

Basic Description

Synonyms	EC 201-758-7 \| 1092805-08-7 \| 2,6-Dimethylaniline \| 2,6-Dimethyl-aniline \| CAS-87-62-7 \| (2,6-dimethylphenyl)amine \| (2,6-dimethyl-phenyl)-amine \| D0669 \| 2,6-DMA \| 2-Amino-m-xylene \| EINECS 201-758-7 \| AKOS000120115 \| Aniline, 2,6-dimethyl- \| Aniline,6-d
Specifications & Purity	≥99%
Storage Temp	Argon charged
Shipped In	Normal

Associated Targets(Human)

RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)

Discover Target: RUNX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Salmonella typhimurium (15756 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488180194
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180194
IUPAC Name	2,6-dimethylaniline
INCHI	InChI=1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3
InChi Key	UFFBMTHBGFGIHF-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=CC=C1)C)N
Isomeric SMILES	CC1=C(C(=CC=C1)C)N
WGK Germany	2
RTECS	ZE9275000
PubChem CID	6896
UN Number	1711
Packing Group	II
Molecular Weight	121.18
Beilstein	121107
Reaxy-Rn	636332

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
J2309142	Certificate of Analysis	Sep 16, 2023	D105633
J2309143	Certificate of Analysis	Sep 16, 2023	D105633
J2309144	Certificate of Analysis	Sep 16, 2023	D105633
J2309145	Certificate of Analysis	Sep 16, 2023	D105633
J2309146	Certificate of Analysis	Sep 16, 2023	D105633
K2408172	Certificate of Analysis	Sep 16, 2023	D105633
B2309306	Certificate of Analysis	Feb 14, 2023	D105633
B2309311	Certificate of Analysis	Feb 14, 2023	D105633
B2301581	Certificate of Analysis	Feb 06, 2023	D105633
E2325056	Certificate of Analysis	Nov 11, 2021	D105633
G2313222	Certificate of Analysis	Nov 11, 2021	D105633
G2415349	Certificate of Analysis	Nov 11, 2021	D105633
H2224240	Certificate of Analysis	Nov 11, 2021	D105633
J2225080	Certificate of Analysis	Nov 11, 2021	D105633

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Chemical and Physical Properties

Solubility	Slightly miscible with water. Miscible with ethanol and diethyl ether.
Sensitivity	Light & Air Sensitive
Freezing Point(°C)	10 °C
Refractive Index	1.56
Flash Point(°F)	195.8 °F
Flash Point(°C)	91 °C
Boil Point(°C)	214°C
Melt Point(°C)	10-12°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09, GHS05
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H351:Suspected of causing cancer H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P410:Protect from sunlight. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	ZE9275000
Reaxy-Rn	636332
Class	6.1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Kai Cheng,Jie-Pin Hu,Yan-Cheng Wu,Chu-Qi Shi,Zhi-Geng Chen,Shu-Mei Liu,Yan-Chao Yuan,Yue-Qi Mo,Jian-Qing Zhao. (2019-07-18) Microwave-assisted synthesis of high thermal stability and colourless polyimides containing pyridine.. Royal Society open science, 6 ((6)): (190196-190196). [PMID:31312489]
2. Wenxiang Zhang, Zhongquan Peng, Xi Zhang, Qiwei Pan, Shumei Liu, Bo Cao, Jianqing Zhao. (2022) Soluble Liquid Crystalline Poly(ester imide)s with High Glass Transition Temperatures and Improved Dielectric Properties. ACS Applied Polymer Materials, 4 (6): (4234–4243). [PMID:] [10.1021/acsapm.2c00211]
3. Ruijuan Duan, Meiling Qi. (2022) Separation performance of pentiptycene-functionalized triblock copolymers towards the isomers of xylenes, phenols and anilines and the complex components in essential oil. JOURNAL OF CHROMATOGRAPHY A, 1669 (462927). [PMID:35278809] [10.1016/j.chroma.2022.462927]
4. Ning Liu, NiNa Qiao, Feng-Shou Liu, ShaoHua Wang, Ying Liang. (2020) Bulky α-diimine palladium complexes supported graphene oxide as heterogeneous catalysts for Suzuki-Miyaura reaction. JOURNAL OF MOLECULAR STRUCTURE, 1218 (128537). [PMID:] [10.1016/j.molstruc.2020.128537]
5. Xue Xiong, Meiling Qi. (2020) Adenine-functionalized polypropylene glycol: A novel stationary phase for gas chromatography offering good inertness for acids and bases combined with a unique selectivity. JOURNAL OF CHROMATOGRAPHY A, 1612 (460627). [PMID:31668867] [10.1016/j.chroma.2019.460627]
6. Zhang Yinchenxi, Duan Yixiang. (2019) A double-functionalized polymeric ionic liquid used as solid-phase microextraction coating for efficient aromatic amine extraction and detection with gas chromatography–mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (10): (2209-2221). [PMID:30879115] [10.1007/s00216-019-01664-x]
7. Yue-Hong Yang, Lan-Tao Liu, Mei-Jun Chen, Song Liu, Cheng-Bin Gong, Yu-Bo Wei, Cheuk-Fai Chow, Qian Tang. (2018) A photoresponsive surface molecularly imprinted polymer shell for determination of trace griseofulvin in milk. Materials Science & Engineering C-Materials for Biological Applications, 92 (365). [PMID:30184762] [10.1016/j.msec.2018.06.069]
8. Tianyun Li, Huahua Huang, Lei Wang, Yongming Chen. (2017) High performance polyimides with good solubility and optical transparency formed by the introduction of alkyl and naphthalene groups into diamine monomers. RSC Advances, 7 (65): (40996-41003). [PMID:] [10.1039/C7RA07142F]
9. Cheng-Bin Gong, Yu-Bo Wei, Lan-Tao Liu, An-Xun Zheng, Yue-Hong Yang, Cheuk-fai Chow, Qian Tang. (2017) Photoresponsive hollow molecularly imprinted polymer for trace triamterene in biological samples. Materials Science & Engineering C-Materials for Biological Applications, 76 (568). [PMID:28482565] [10.1016/j.msec.2017.03.135]

References

1. N W Puente,P D Josephy. (2002-01-05) Analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk.. Journal of analytical toxicology, 25 ((8)): (711-715). [PMID:11765029]
2. Alan M Jeffrey,Feng-Qi Luo,Shantilal Amin,Jacek Krzeminski,Karl Zech,Gary M Williams. (2002-02-20) Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylaniline.. Drug and chemical toxicology, 25 ((1)): (93-107). [PMID:11850974]
3. M Matilde Marques,Gonçalo Gamboa da Costa,Lonnie R Blankenship,Sandra J Culp,Frederick A Beland. (2002-09-28) The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.. Mutation research, 506-507 (41-48). [PMID:12351143]
4. Emil Baczyński,Agata Piwońska,Zbigniew Fijałek. (2003-02-27) Determination of 2,6-dimethylaniline and o-toluidine impurities in preparations for local anaesthesia by the HPLC method with amperometric detection.. Acta poloniae pharmaceutica, 59 ((5)): (333-339). [PMID:12602793]
5. Todd M Delehant,Joseph W Denhart,W Eugene Lloyd,J D Powell. (2003-09-25) Pharmacokinetics of xylazine, 2,6-dimethylaniline, and tolazoline in tissues from yearling cattle and milk from mature dairy cows after sedation with xylazine hydrochloride and reversal with tolazoline hydrochloride.. Veterinary therapeutics : research in applied veterinary medicine, 4 ((2)): (128-134). [PMID:14506588]
6. Usha John,K P R Nair. (2004-07-14) Liquid phase overtone spectral investigations of 2,6-dimethylaniline and 2,4-dimethylaniline-evidence for steric nature of the ortho effect and the consequent base weakening.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60 ((10)): (2337-2341). [PMID:15249023]
7. Eva Tydén,Hans Tjälve,Pia Larsson. (2004-07-16) Metabolic activation of 2,6-xylidine in the nasal olfactory mucosa and the mucosa of the upper alimentary and respiratory tracts in rats.. Toxicological sciences : an official journal of the Society of Toxicology, 81 ((2)): (263-272). [PMID:15254337]
8. Ana P Ferreira Gregorio,Ingrid R Da Silva,Mohammad R Sedarati,John N Hedger. (2006-02-21) Changes in production of lignin degrading enzymes during interactions between mycelia of the tropical decomposer basidiomycetes Marasmiellus troyanus and Marasmius pallescens.. Mycological research, 110 ((Pt 2)): (161-168). [PMID:16488366]
9. Bozena Kaczmarczyk,Agnieszka Iwan,Danuta Sek. (2007-03-03) Temperature investigations of E/Z isomers in ketimines based of p-dibenzoylobenzene with aniline and 2,6-dimethylaniline by infrared spectroscopy.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 68 ((2)): (369-376). [PMID:17331796]
10. Jian-Dong Duan,Alan M Jeffrey,Gary M Williams. (2008-05-21) Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues.. Drug metabolism and disposition: the biological fate of chemicals, 36 ((8)): (1470-1475). [PMID:18490435]
11. Robert J Strife,Michele L Mangels,Julie A Skare. (2009-09-08) Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry.. Journal of chromatography. A, 1216 ((41)): (6970-6973). [PMID:19733358]
12. Nalinrut Masomboon,Chavalit Ratanatamskul,Ming-Chun Lu. (2011-06-08) Kinetics of 2,6-dimethylaniline oxidation by various Fenton processes.. Journal of hazardous materials, 192 ((1)): (347-353). [PMID:21645969]
13. Wang-Ping Ting,Yao-Hui Huang,Ming-Chun Lu. (2011-08-03) Oxidation of 2,6-dimethylaniline by the Fenton, electro-Fenton and photoelectro-Fenton processes.. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 46 ((10)): (1085-1091). [PMID:21806452]
14. David Kirkland,Mark Ballantyne,Stefanie Harlfinger,Olaf Will,Ulrich Jahnel,Alexander Kraus,Corinne van Dorp. (2011-09-20) Further investigations into the genotoxicity of 2,6-xylidine and one of its key metabolites.. Regulatory toxicology and pharmacology : RTP, 62 ((1)): (151-159). [PMID:21925229]
15. Chavalit Ratanatamskul,Sutthinee Narkwittaya,Nalinrut Masomboon,Ming-Chun Lu. (2011-10-06) Effect of carrier composition on 2,6-dimethylaniline degradation in aqueous solution by fluidized-bed Fenton process.. Environmental technology, 32 ((11-12)): (1233-1237). [PMID:21970165]
16. Mai Shimizu,Tatsuki Fukami,Miki Nakajima,Tsuyoshi Yokoi. (2014-04-23) Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase.. Drug metabolism and disposition: the biological fate of chemicals, 42 ((7)): (1103-1109). [PMID:24751575]
17. Hoa Q Nguyen,Stephen D Stamatis,Lee E Kirsch. (2015-04-23) A Novel Method for Assessing Drug Degradation Product Safety Using Physiologically-Based Pharmacokinetic Models and Stochastic Risk Assessment.. Journal of pharmaceutical sciences, 104 ((9)): (3101-3119). [PMID:25900395]
18. Xue Gao,Hao Guo,Yaoyu Du,Chaokang Gu. (2015-04-25) Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry.. Journal of analytical toxicology, 39 ((6)): (444-450). [PMID:25907168]
19. . (1993-01-01) 2,6-Dimethylaniline (2,6-xylidine).. IARC monographs on the evaluation of carcinogenic risks to humans, 57 (323-335). [PMID:8207863]
20. Włodzimierz Białasiewicz,Wincenty Kwapiszewski,Elzbieta Zurek,Andrzej Olczak,Marek Główka,Rościsław Polakowski. (2004-10-16) Synthesis, structure and pharmacology of acyl-2,6-xylidines.. Acta poloniae pharmaceutica, 61 ((3)): (215-221). [PMID:15481248]
21. Wang-Ping Ting,Ming-Chun Lu,Yao-Hui Huang. (2008-06-17) Kinetics of 2,6-dimethylaniline degradation by electro-Fenton process.. Journal of hazardous materials, 161 ((2-3)): (1484-1490). [PMID:18554787]
22. Nonglak Boonrattanakij,Ming-Chun Lu,Jin Anotai. (2009-08-21) Kinetics and mechanism of 2,6-dimethyl-aniline degradation by hydroxyl radicals.. Journal of hazardous materials, 172 ((2-3)): (952-957). [PMID:19692169]
23. Wei Han,Armin R Ofial. (2009-10-08) Iron-catalyzed dehydrogenative phosphonation of N,N-dimethylanilines.. Chemical communications (Cambridge, England), (40) ((40)): (6023-6025). [PMID:19809631]
24. Nalinrut Masomboon,Chavalit Ratanatamskul,Ming-Chun Lu. (2009-12-24) Chemical oxidation of 2,6-dimethylaniline in the fenton process.. Environmental science & technology, 43 ((22)): (8629-8634). [PMID:20028063]
25. Asli Karakas,Hüseyin Unver. (2010-03-03) Third-order nonlinear optical properties and structures of (E)-N-(4-nitrobenzylidene)-2,6-dimethylaniline and (E)-N-(4-nitrobenzylidene)-2,3-dimethylaniline.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75 ((5)): (1492-1496). [PMID:20194047]
26. Kai Cheng,Jie-Pin Hu,Yan-Cheng Wu,Chu-Qi Shi,Zhi-Geng Chen,Shu-Mei Liu,Yan-Chao Yuan,Yue-Qi Mo,Jian-Qing Zhao. (2019-07-18) Microwave-assisted synthesis of high thermal stability and colourless polyimides containing pyridine.. Royal Society open science, 6 ((6)): (190196-190196). [PMID:31312489]
27. Wenxiang Zhang, Zhongquan Peng, Xi Zhang, Qiwei Pan, Shumei Liu, Bo Cao, Jianqing Zhao. (2022) Soluble Liquid Crystalline Poly(ester imide)s with High Glass Transition Temperatures and Improved Dielectric Properties. ACS Applied Polymer Materials, 4 (6): (4234–4243). [PMID:] [10.1021/acsapm.2c00211]
28. Ruijuan Duan, Meiling Qi. (2022) Separation performance of pentiptycene-functionalized triblock copolymers towards the isomers of xylenes, phenols and anilines and the complex components in essential oil. JOURNAL OF CHROMATOGRAPHY A, 1669 (462927). [PMID:35278809] [10.1016/j.chroma.2022.462927]
29. Ning Liu, NiNa Qiao, Feng-Shou Liu, ShaoHua Wang, Ying Liang. (2020) Bulky α-diimine palladium complexes supported graphene oxide as heterogeneous catalysts for Suzuki-Miyaura reaction. JOURNAL OF MOLECULAR STRUCTURE, 1218 (128537). [PMID:] [10.1016/j.molstruc.2020.128537]
30. Xue Xiong, Meiling Qi. (2020) Adenine-functionalized polypropylene glycol: A novel stationary phase for gas chromatography offering good inertness for acids and bases combined with a unique selectivity. JOURNAL OF CHROMATOGRAPHY A, 1612 (460627). [PMID:31668867] [10.1016/j.chroma.2019.460627]
31. Zhang Yinchenxi, Duan Yixiang. (2019) A double-functionalized polymeric ionic liquid used as solid-phase microextraction coating for efficient aromatic amine extraction and detection with gas chromatography–mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (10): (2209-2221). [PMID:30879115] [10.1007/s00216-019-01664-x]
32. Yue-Hong Yang, Lan-Tao Liu, Mei-Jun Chen, Song Liu, Cheng-Bin Gong, Yu-Bo Wei, Cheuk-Fai Chow, Qian Tang. (2018) A photoresponsive surface molecularly imprinted polymer shell for determination of trace griseofulvin in milk. Materials Science & Engineering C-Materials for Biological Applications, 92 (365). [PMID:30184762] [10.1016/j.msec.2018.06.069]
33. Tianyun Li, Huahua Huang, Lei Wang, Yongming Chen. (2017) High performance polyimides with good solubility and optical transparency formed by the introduction of alkyl and naphthalene groups into diamine monomers. RSC Advances, 7 (65): (40996-41003). [PMID:] [10.1039/C7RA07142F]
34. Cheng-Bin Gong, Yu-Bo Wei, Lan-Tao Liu, An-Xun Zheng, Yue-Hong Yang, Cheuk-fai Chow, Qian Tang. (2017) Photoresponsive hollow molecularly imprinted polymer for trace triamterene in biological samples. Materials Science & Engineering C-Materials for Biological Applications, 76 (568). [PMID:28482565] [10.1016/j.msec.2017.03.135]

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