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2-(6-phenyl-1,3-benzothiazole-2-carbonyl)-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole , CAS No.P608687, Inhibitor of lipase G; endothelial type

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2-(6-phenyl-1,3-benzothiazole-2-carbonyl)-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole , CAS No.P608687, Inhibitor of lipase G; endothelial type

Moligand™

PubChem CID: 90057968

Item Number

P608687

Grouped product items
SKU	Size	Availability	Price	Qty
P608687-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
P608687-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

lipase G，endothelial type Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of lipase G; endothelial type

Associated Targets(Human)

LIPC Tchem Hepatic triacylglycerol lipase (1 Activities)

Discover Target: LIPC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIPG Tchem Endothelial lipase (3 Activities)

Discover Target: LIPG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIPC Tchem Hepatic lipase (436 Activities)

Discover Target: LIPC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-(6-phenyl-1,3-benzothiazole-2-carbonyl)-5-[(sulfamoylamino)methyl]-1,3,4-oxadiazole
INCHI	InChI=1S/C17H13N5O4S2/c18-28(24,25)19-9-14-21-22-16(26-14)15(23)17-20-12-7-6-11(8-13(12)27-17)10-4-2-1-3-5-10/h1-8,19H,9H2,(H2,18,24,25)
InChi Key	LXSODRTWQNWTOG-UHFFFAOYSA-N
Canonical SMILES	O=C(c1nc2c(s1)cc(cc2)c1ccccc1)c1nnc(o1)CNS(=O)(=O)N
Isomeric SMILES	C1=CC=C(C=C1)C2=CC3=C(C=C2)N=C(S3)C(=O)C4=NN=C(O4)CNS(=O)(=O)N
PubChem CID	90057968

Database links

PubChem CID	90057968

Certificates

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References

1. Tora G, Kim SH, Pi Z, Johnson JA, Jiang J, Phillips M, Lloyd J, Abell LM, Lu H, Locke G et al.. (2020) Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.. J Med Chem, 63 (4): (1660-1670). [PMID:31990537] [10.1021/acs.jmedchem.9b01831]

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