Grouped product items

SKU

Size

Availability

Price

Qty

A151201-25g

25g

In stock

$75.90

A151201-100g

100g

In stock

$230.90

A151201-500g

500g

Available within 4-8 weeks(?)

$888.90

Basic Description

Synonyms	2-AMINO-5-NITROTHIAZOLE \| 121-66-4 \| 5-Nitrothiazol-2-amine \| Enheptin \| 5-Nitro-1,3-thiazol-2-amine \| Entramin \| Nitramin IDO \| Amnizol soluble \| Enheptin-T \| 5-Nitro-2-thiazolamine \| 2-Thiazolamine, 5-nitro- \| Enheptin premix \| Aminonitrothiazole \| Aminzol soluble \| Thiazole, 2-am
Specifications & Purity	≥98%(HPLC)
Shipped In	Normal
Product Description	2-Amino-5-nitrothiazole(ANT) is a hypoxic radiosensitizing drug. ANT forms square-planar complex, trans-[PdCl2(ANT)2] with palladium in methanol 2-Amino-5-nitrothiazole was used as diazo component in the synthesis of monoazo disperse dyes. It was used as matrix during matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of oligonucleotide and protein.

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (0 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin (0 Activities)

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (0 Activities)

Discover Target: PLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (0 Activities)

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B (0 Activities)

Discover Target: ALOX15B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase (0 Activities)

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATXN2 Tbio Ataxin-2 (0 Activities)

Discover Target: ATXN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAA2 Tchem 5'-AMP-activated protein kinase catalytic subunit alpha-2 (0 Activities)

Discover Target: PRKAA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (0 Activities)

Discover Target: IDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKAA2 Tchem AMP-activated protein kinase, alpha-2 subunit (1328 Activities)

Discover Target: PRKAA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

Discover Target: HPGD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATXN2 Tbio Ataxin-2 (54410 Activities)

Discover Target: ATXN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Leishmania amazonensis (3813 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma cruzi (99888 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trichomonas vaginalis (2376 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Giardia intestinalis (1290 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488180810
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180810
IUPAC Name	5-nitro-1,3-thiazol-2-amine
INCHI	InChI=1S/C3H3N3O2S/c4-3-5-1-2(9-3)6(7)8/h1H,(H2,4,5)
InChi Key	MIHADVKEHAFNPG-UHFFFAOYSA-N
Canonical SMILES	C1=C(SC(=N1)N)[N+](=O)[O-]
Isomeric SMILES	C1=C(SC(=N1)N)[N+](=O)[O-]
WGK Germany	3
RTECS	XJ2800000
PubChem CID	8486
UN Number	2811
Packing Group	I
Molecular Weight	145.14
Beilstein	126797
Reaxy-Rn	126797

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
L1923066	Certificate of Analysis	Oct 20, 2023	A151201
J1824171	Certificate of Analysis	Aug 11, 2022	A151201
C2306894	Certificate of Analysis	Nov 19, 2021	A151201
E2316883	Certificate of Analysis	Nov 19, 2021	A151201
F2314407	Certificate of Analysis	Nov 19, 2021	A151201
K2113282	Certificate of Analysis	Nov 19, 2021	A151201

Chemical and Physical Properties

Solubility	95% ethanol: soluble 1g/150g at 20 °C； diethyl ether: soluble 1g/250g at 20 °C； chloroform: insoluble； water: slightly soluble； hot Methanol：very faint turbidity；
Melt Point(°C)	202℃

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H351:Suspected of causing cancer H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	XJ2800000
Reaxy-Rn	126797
Class	6.1
Merck Index	457

Citations of This Product

1. Yadong Wang, Li Ma, Jun Yuan, Zongmin Zhu, Xiaoming Liu, Dengsong Li, Liqing He, Fei Xiao. (2023) Furfural-based P/N/S flame retardant towards high-performance epoxy resins with flame retardancy, toughness, low dielectric properties and UV resistance. POLYMER DEGRADATION AND STABILITY, 212 (110343). [PMID:]

References

1. K A Skov,N P Farrell,H Adomat. (1987-11-01) Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro.. Radiation research, 112 ((2)): (273-282). [PMID:3685256]
2. . (1983-07-01) 2-amino-5-nitrothiazole.. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 31 (71-77). [PMID:6579018]
3. S Rockwell,Z Mroczkowski,W D Rupp. (1982-06-01) Evaluation of 2-amino-5-nitrothiazole as a hypoxic cell radiosensitizer.. Radiation research, 90 ((3)): (575-585). [PMID:7045963]
4. T Eric Ballard,Xia Wang,Igor Olekhnovich,Taylor Koerner,Craig Seymour,Paul S Hoffman,Timothy L Macdonald. (2010-05-22) Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide.. Bioorganic & medicinal chemistry letters, 20 ((12)): (3537-3539). [PMID:20488706]
5. Yadong Wang, Li Ma, Jun Yuan, Zongmin Zhu, Xiaoming Liu, Dengsong Li, Liqing He, Fei Xiao. (2023) Furfural-based P/N/S flame retardant towards high-performance epoxy resins with flame retardancy, toughness, low dielectric properties and UV resistance. POLYMER DEGRADATION AND STABILITY, 212 (110343). [PMID:]

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2-Amino-5-nitrothiazole - >98.0%(HPLC), high purity , CAS No.121-66-4