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2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynyl-1H-purine-6,8-dione , CAS No.A609027, Agonist of TLR7

2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynyl-1H-purine-6,8-dione , CAS No.A609027, Agonist of TLR7

Item Number

A609027

Grouped product items
SKU	Size	Availability	Price	Qty
A609027-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
A609027-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

TLR7 Tclin Toll-like receptor 7 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynyl-1H-purine-6,8-dione
INCHI	InChI=1S/C13H14FN5O5/c1-2-3-18-7-9(16-12(15)17-10(7)22)19(13(18)23)11-8(21)6(14)5(4-20)24-11/h1,5-6,8,11,20-21H,3-4H2,(H3,15,16,17,22)/t5-,6-,8-,11-/m1/s1
InChi Key	TVTJUIAKQFIXCE-HUKYDQBMSA-N
Canonical SMILES	Nc1[nH]c(=O)c2n(c(=O)n(c2n1)[C@@H]1O[C@@H]([C@H]([C@H]1O)F)CO)CC#C
PubChem CID	153282971

PubChem CID	153282971

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1. Solanich X, Vargas-Parra G, van der Made CI, Simons A, Schuurs-Hoeijmakers J, Antolí A, Del Valle J, Rocamora-Blanch G, Setién F, Esteller M et al.. (2021) Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19.. Front Immunol, 12 (13): (719115). [PMID:34367187] [10.1021/op500134e]
2. Szeto MD, Maghfour J, Sivesind TE, Anderson J, Olayinka JT, Mamo A, Runion TM, Dellavalle RP. (2021) Interferon and Toll-Like Receptor 7 Response in COVID-19: Implications of Topical Imiquimod for Prophylaxis and Treatment.. Dermatology, 237 (6): (847-856). [PMID:34511591] [10.1021/op500134e]

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