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2-Aminoethyl diphenylborinate - 98%, high purity , CAS No.524-95-8, Channel blocker of TRPC1;Channel blocker of TRPC3;Channel blocker of TRPC4;Channel blocker of TRPC5;Channel blocker of TRPC6;Channel blocker of TRPC7;Channel blocker of TRPM2;Gating inhibitor of TRPM3;Activator of TRPM6;Activator of TRPM7;Channel blocker

2 Citations

Moligand™

≥98%

CAS#: 524-95-8
Formula: C₁₄H₁₆BNO
Molecular Weight: 225.09
Beilstein Registry Number: 2942273
EC Number: 208-366-5
MDL number: MFCD00014823
PubChem CID: 1598
PubChem SID: 488179629

Item Number

A106408

Grouped product items
SKU	Size	Availability	Price
A106408-1g	1g	In stock	$15.90
A106408-5g	5g	In stock	$61.90
A106408-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$110.90
A106408-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90

Ca 2+ release modulator

Basic Description

Synonyms	MFCD00014823 \| SB79870 \| BORINIC ACID, B,B-DIPHENYL-, 2-AMINOETHYL ESTER \| 2-Aminoethyl diphenylborinate \| C14H16BNO \| UNII-E4ES684O93 \| 2-aminoethoxydephenylborate \| STL481977 \| HB1208 \| 2-((Diphenylboryl)oxy)ethanamine \| 2-(Diphenylboryloxy)Ethanamine \|
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Cell-permeable, allosteric inhibitor of D- myo -inositol 1,4,5-trisphosphate (IP3) -induced Ca 2+ release . Inhibits IP3-induced Ca 2+ release without affecting IP3 receptor binding. Blocks store operated Ca 2+ entry.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR, CHANNEL BLOCKER, GATING INHIBITOR
Mechanism of action	Channel blocker of TRPC1;Channel blocker of TRPC3;Channel blocker of TRPC4;Channel blocker of TRPC5;Channel blocker of TRPC6;Channel blocker of TRPC7;Channel blocker of TRPM2;Gating inhibitor of TRPM3;Activator of TRPM6;Activator of TRPM7;Channel blocker
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.

Associated Targets(Human)

TRPM2 Tchem Transient receptor potential cation channel subfamily M member 2 (6 Activities)

Discover Target: TRPM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM6 Tchem Transient receptor potential cation channel subfamily M member 6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM7 Tchem Transient receptor potential cation channel subfamily M member 7 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV6 Tchem Transient receptor potential cation channel subfamily V member 6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC3 Tchem Short transient receptor potential channel 3 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC4 Tchem Short transient receptor potential channel 4 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC6 Tchem Short transient receptor potential channel 6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC7 Tchem Short transient receptor potential channel 7 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC1 Tbio Short transient receptor potential channel 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV2 Tchem Transient receptor potential cation channel subfamily V member 2 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM8 Tclin Transient receptor potential cation channel subfamily M member 8 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV1 Tclin Vanilloid receptor (8273 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (542 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPM2 Tchem Transient receptor potential cation channel subfamily M member 2 (348 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPM7 Tchem Transient receptor potential cation channel subfamily M member 7 (19 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

Discover Target: HPGD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ORAI1 Tchem Calcium release-activated calcium channel protein 1 (150 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD2 Tbio Mothers against decapentaplegic homolog 2 (9 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

Discover Target: Trpv2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lef Anthrax lethal factor (7585 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATP2A1 Sarcoplasmic/endoplasmic reticulum calcium ATP-ase (121 Activities)

Discover Target: ATP2A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 Activities)

Discover Target: Trpm8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488179629
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179629
IUPAC Name	2-diphenylboranyloxyethanamine
INCHI	InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChi Key	BLZVCIGGICSWIG-UHFFFAOYSA-N
Canonical SMILES	B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
Isomeric SMILES	B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
WGK Germany	3
RTECS	ED6150000
PubChem CID	1598
Molecular Weight	225.09
Beilstein	2942273
Reaxy-Rn	2942273

Database links

PubChem CID	1598
CAS Registry No.	524-95-8
Wikipedia	2-Aminoethoxydiphenyl_borate
ChEMBL Ligand	CHEMBL169233
RCSB PDB Ligand	FZ4
PubChem SID	488179629

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
C2420151	Certificate of Analysis	Mar 12, 2024	A106408
C2420300	Certificate of Analysis	Mar 12, 2024	A106408
B2324099	Certificate of Analysis	Mar 02, 2023	A106408
B2207016	Certificate of Analysis	Jan 17, 2022	A106408
B2207071	Certificate of Analysis	Jan 17, 2022	A106408
B2207072	Certificate of Analysis	Jan 17, 2022	A106408
B2324105	Certificate of Analysis	Jan 17, 2022	A106408

Chemical and Physical Properties

Solubility	Soluble in Methanol
Sensitivity	Light and Moisture Sensitive
Melt Point(°C)	190-194°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
WGK Germany	3
RTECS	ED6150000
Reaxy-Rn	2942273

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Kong Yuanyuan, Hu Xiaoli, Zhong Yingqun, Xu Ke, Wu Buling, Zheng Jianmao. (2019) Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling. Stem Cell Research & Therapy, 10 (1): (1-11). [PMID:31823825] [10.1186/s13287-019-1493-5]
2. Luo M et al.. (2020) Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.. Biol Pharm Bull, 43 (7): (1027-1034). [PMID:32404582]

References

1. Kamm GB et al.. (2021) A synaptic temperature sensor for body cooling.. Neuron, 109 (20): (3283-3297.e11). [PMID:34672983]
2. Xie Q et al.. (2016) ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.. Int J Oncol, 49 (6): (2507-2519). [PMID:27748803]
3. Tchernookova BK et al.. (2018) Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux.. PLoS One, 13 (2): (e0190893). [PMID:29466379]
4. Xu L et al.. (2018) Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.. Oncol Rep, 39 (3): (985-992). [PMID:29286126]
5. Andriulė I et al.. (2022) Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes.. Int J Mol Sci, 23 (23): [PMID:36499188]
6. Andriule I et al.. (2021) Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.. Sci Rep, 11 (15445). [PMID:34326388]
7. Shen Y et al.. (2019) Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions.. Nat Commun, 10 (2924). [PMID:31266950]
8. Wang Y et al.. (2017) FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry.. Onco Targets Ther, 10 (5317-5328). [PMID:29184418]
9. Doengi M et al.. (2009) GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes.. Proc Natl Acad Sci U S A, 106 (41): (17570-5). [PMID:19805126]
10. King CM et al.. (2020) Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals.. Cell Rep, 30 (10): (3466-3477.e4). [PMID:32160550]
11. Kubota H et al.. (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.. PLoS One, 9 (9): (e106316). [PMID:25181481]
12. Li C et al.. (2022) PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.. Front Cell Dev Biol, 10 (896014). [PMID:35874841]
13. Bai D et al.. (2020) Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication.. Virology, 539 (38-48). [PMID:31670218]
14. Heeley N et al.. (2018) Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.. Mol Metab, 10 (14-27). [PMID:29439854]
15. Xie Q et al.. (2018) TAT-fused IP3R-derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.. Int J Mol Med, 41 (2): (809-817). [PMID:29207009]
16. Li L et al.. (2020) TRPM7 modulates macrophage polarization by STAT1/STAT6 pathways in RAW264.7\xa0cells.. Biochem Biophys Res Commun, 533 (4): (692-697). [PMID:33153718]
17. Kong Yuanyuan, Hu Xiaoli, Zhong Yingqun, Xu Ke, Wu Buling, Zheng Jianmao. (2019) Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling. Stem Cell Research & Therapy, 10 (1): (1-11). [PMID:31823825] [10.1186/s13287-019-1493-5]
18. Luo M et al.. (2020) Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.. Biol Pharm Bull, 43 (7): (1027-1034). [PMID:32404582]

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Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

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