2-Aminoethyl diphenylborinate - 10mM in DMSO, high purity , CAS No.524-95-8

Item Number

A424505

• Synonyms: 524-95-8 | 2-Aminoethyl diphenylborinate | 2-APB | (2-Aminoethoxy)diphenylborane | 2-Aminoethoxydiphenylborane | 2-((Diphenylboryl)oxy)ethanamine | 2-aminoethoxydiphenyl borate | 2-Aminoethoxydiphenylborate | 2-diphenylboranyloxyethanamine | Borinic acid, diphenyl-, 2-amin
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: Cell-permeable, allosteric inhibitor of D- myo -inositol 1,4,5-trisphosphate (IP3) -induced Ca 2+ release . Inhibits IP3-induced Ca 2+ release without affecting IP3 receptor binding. Blocks store operated Ca 2+ entry.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.