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2-Aminopurine - 98%, high purity , CAS No.452-06-2
Basic Description Synonyms 2-AP | AKOS006220998 | 2'-amino-purine | 2-aminopurine | NSC24129 | NSC-24129 | PD044966 | 2-amino purine | HY-W012642 | NSC 24129 | AC-13347 | 2BP | DTXSID40196416 | SQ 22,451 | SQ 22451 | 1H-PURIN-2-AMINE | MLS001333096 | 7H-Purin-2-ylamine | 9H-Purin-2 Specifications & Purity ≥98% Biochemical and Physiological Mechanisms 2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinas Storage Temp Store at 2-8°C Shipped In Wet ice Product Description 2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
Product Application：
2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.
2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488181055 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488181055 IUPAC Name 7H-purin-2-amine INCHI InChI=1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10) InChi Key MWBWWFOAEOYUST-UHFFFAOYSA-N Canonical SMILES C1=C2C(=NC(=N1)N)N=CN2 Isomeric SMILES C1=C2C(=NC(=N1)N)N=CN2 WGK Germany 3 RTECS UO7475000 PubChem CID 9955 Molecular Weight 135.13 Beilstein 26(3/4)3559 Reaxy-Rn 608088
Chemical and Physical Properties Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3 RTECS UO7475000 Reaxy-Rn 608088
Citations of This Product 1. Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang. (2020) Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand. APPLIED SURFACE SCIENCE, 503 (144303). [PMID: [10.1016/j.apsusc.2019.144303 ]
References 1. Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang. (2020) Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand. APPLIED SURFACE SCIENCE, 503 (144303). [PMID: [10.1016/j.apsusc.2019.144303 ]
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