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SKU

Size

Availability

Price

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B191082-50ml

50ml

Available within 4-8 weeks(?)

$219.90

Basic Description

Synonyms	halothane\|151-67-7\|2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE\|Fluothane\|Narcotane\|Rhodialothan\|Anestan\|Bromochlorotrifluoroethane\|Phthorothanum\|Ftuorotan\|Halothan\|Narcotan\|Fluorotane\|Fluktan\|Ftorotan\|Narkotan\|Halotano\|Freon 123B1\|Halotan\|Halsan\|Halan\|Chalotha
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR, CHANNEL BLOCKER, GATING INHIBITOR, INHIBITOR, POSITIVE MODULATOR
Mechanism of action	Potassium channel subfamily K member 18 opener
Product Description	Application 2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.

Product Properties

ALogP	2.3

Associated Targets

CYP2E1 Tchem Cytochrome P450 2E1 0 Activities

Discover Target: CYP2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ6 Tchem G protein-activated inward rectifier potassium channel 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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ALB Tchem Serum albumin 0 Activities

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MAOB Tclin Amine oxidase [flavin-containing] B 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK2 Tclin Potassium channel subfamily K member 2 0 Activities

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK3 Tclin Potassium channel subfamily K member 3 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK5 Tchem Potassium channel subfamily K member 5 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK12 Tbio Potassium channel subfamily K member 12 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK9 Tclin Potassium channel subfamily K member 9 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK10 Tclin Potassium channel subfamily K member 10 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK13 Tbio Potassium channel subfamily K member 13 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNB1 Tclin Potassium voltage-gated channel subfamily B member 1 1 Activities

Discover Target: KCNB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-bromo-2-chloro-1,1,1-trifluoroethane
INCHI	InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChi Key	BCQZXOMGPXTTIC-UHFFFAOYSA-N
Canonical SMILES	C(C(F)(F)F)(Cl)Br
Isomeric SMILES	C(C(F)(F)F)(Cl)Br
PubChem CID	3562
UN Number	3082
Packing Group	III
Molecular Weight	197.38

Database links

PubChem CID	3562
ChEBI	CHEBI:5615
CAS Registry No.	151-67-7
Wikipedia	Halothane
ChEMBL Ligand	CHEMBL931
DrugBank Ligand	DB01159
BindingDB Ligand	50112212
DrugCentral Ligand	1356

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
J2330220	Certificate of Analysis	Oct 24, 2023	B191082
G2326431	Certificate of Analysis	Nov 05, 2022	B191082

Chemical and Physical Properties

Solubility	Soluble in water (8 mg/ml)
Sensitivity	Light sensitive
Refractive Index	n20/D 1.369
Boil Point(°C)	50.2 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H318:Causes serious eye damage H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
Class	9

Alternative Products

References

1. Meadows HJ, Randall AD. (2001) Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel.. Neuropharmacology, 40 (4): (551-9). [PMID:11249964]
2. Talley EM, Bayliss DA. (2002) Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action.. J Biol Chem, 277 (20): (17733-42). [PMID:11886861]

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2-Bromo-2-chloro-1,1,1-trifluoroethane - 99%, high purity , Potassium channel subfamily K member 18 opener, CAS No.151-67-7, Potassium channel subfamily K member 18 opener