2-Bromo-2-chloro-1,1,1-trifluoroethane - 99%, high purity , Potassium channel subfamily K member 18 opener, CAS No.151-67-7, Potassium channel subfamily K member 18 opener

Item Number
B191082
Grouped product items
SKUSizeAvailabilityPrice Qty
B191082-50ml
50ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$219.90

Basic Description

SynonymsAlotano | CAS-151-67-7 | CCG-213438 | DTXCID605371 | Fluothane, Halothane, USP | HMS2094K17 | Halotano | Narkotan | NCGC00090868-02 | ETHANE, 2-BROMO-2-CHLORO-1,1,1-TRIFLUORO-,(+/-)- | Halothane [Anaesthetics, volatile] | HY-B1010 | Freon 123B1 | Narcotan
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological Mechanisms2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, CHANNEL BLOCKER, GATING INHIBITOR, INHIBITOR, POSITIVE MODULATOR
Mechanism of actionPotassium channel subfamily K member 18 opener
Product Description

Application

2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.

Product Properties

ALogP2.3

Associated Targets(Human)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNJ6 Tchem G protein-activated inward rectifier potassium channel 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK2 Tclin Potassium channel subfamily K member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK3 Tclin Potassium channel subfamily K member 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK5 Tchem Potassium channel subfamily K member 5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK12 Tbio Potassium channel subfamily K member 12 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK9 Tclin Potassium channel subfamily K member 9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK10 Tclin Potassium channel subfamily K member 10 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK13 Tbio Potassium channel subfamily K member 13 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNB1 Tclin Potassium voltage-gated channel subfamily B member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALB Tchem Serum albumin (2651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2E1 Tchem Cytochrome P450 2E1 (2174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Kcnk3 Potassium channel subfamily K member 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Kcnk9 Potassium channel subfamily K member 9 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-bromo-2-chloro-1,1,1-trifluoroethane
INCHI InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChi Key BCQZXOMGPXTTIC-UHFFFAOYSA-N
Canonical SMILES C(C(F)(F)F)(Cl)Br
Isomeric SMILES C(C(F)(F)F)(Cl)Br
PubChem CID 3562
UN Number 3082
Packing Group III
Molecular Weight 197.38

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
J2330220Certificate of AnalysisOct 24, 2023 B191082
G2326431Certificate of AnalysisNov 05, 2022 B191082

Chemical and Physical Properties

SolubilitySoluble in water (8 mg/ml)
SensitivityLight sensitive
Refractive Indexn20/D 1.369
Boil Point(°C)50.2 °C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H335:May cause respiratory irritation

H341:Suspected of causing genetic defects

H318:Causes serious eye damage

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P281:Use personal protective equipment as required.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Class 9

Related Documents

References

1. Meadows HJ, Randall AD.  (2001)  Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel..  Neuropharmacology,  40  (4): (551-9).  [PMID:11249964] [10.1021/op500134e]
2. Talley EM, Bayliss DA.  (2002)  Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action..  J Biol Chem,  277  (20): (17733-42).  [PMID:11886861] [10.1021/op500134e]

Solution Calculators