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Tailless-like receptors
2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide , CAS No.B608647, Agonist of TLX

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2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide , CAS No.B608647, Agonist of TLX

Moligand™

PubChem CID: 162679531

Item Number

B608647

Grouped product items
SKU	Size	Availability	Price	Qty
B608647-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
B608647-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

TLX Agonist

Basic Description

Synonyms	compound 10
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of TLX

Associated Targets(Human)

NR2E1 Tbio Nuclear receptor subfamily 2 group E member 1 (0 Activities)

Discover Target: NR2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR2E1 Tbio Nuclear receptor subfamily 2 group E member 1 (116 Activities)

Discover Target: NR2E1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide
INCHI	InChI=1S/C25H23F3N4O2/c1-3-4-9-34-23-13-21(20-7-5-6-8-22(20)31-23)24(33)30-18-10-17(25(26,27)28)11-19(12-18)32-14-16(2)29-15-32/h5-8,10-15H,3-4,9H2,1-2H3,(H,30,33)
InChi Key	RTKBIHCZDFXHLC-UHFFFAOYSA-N
Canonical SMILES	O=C(c1cc(OCCCC)nc2c1cccc2)Nc1cc(C(F)(F)F)cc(n2cc(C)nc2)c1
Isomeric SMILES	CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NC3=CC(=CC(=C3)C(F)(F)F)N4C=C(N=C4)C
PubChem CID	162679531

Database links

PubChem CID	162679531

Certificates

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References

1. Faudone G, Zhubi R, Celik F, Knapp S, Chaikuad A, Heering J, Merk D. (2022) Design of a Potent TLX Agonist by Rational Fragment Fusion.. J Med Chem, 129 (3): (589-97). [PMID:34989568]

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