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Tailless-like receptors
2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide , CAS No.B608647, Agonist of TLX

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2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide , CAS No.B608647, Agonist of TLX

Moligand™

PubChem CID: 162679531

Item Number

B608647

Grouped product items
SKU	Size	Availability	Price	Qty
B608647-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
B608647-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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TLX Agonist

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of TLX

Associated Targets(Human)

NR2E1 Tbio Nuclear receptor subfamily 2 group E member 1 (0 Activities)

Discover Target: NR2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR2E1 Tbio Nuclear receptor subfamily 2 group E member 1 (116 Activities)

Discover Target: NR2E1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-Butyloxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide
INCHI	InChI=1S/C25H23F3N4O2/c1-3-4-9-34-23-13-21(20-7-5-6-8-22(20)31-23)24(33)30-18-10-17(25(26,27)28)11-19(12-18)32-14-16(2)29-15-32/h5-8,10-15H,3-4,9H2,1-2H3,(H,30,33)
InChi Key	RTKBIHCZDFXHLC-UHFFFAOYSA-N
Canonical SMILES	O=C(c1cc(OCCCC)nc2c1cccc2)Nc1cc(C(F)(F)F)cc(n2cc(C)nc2)c1
Isomeric SMILES	CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NC3=CC(=CC(=C3)C(F)(F)F)N4C=C(N=C4)C
PubChem CID	162679531

Database links

PubChem CID	162679531

Certificates

Certificate of Analysis(COA)

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References

1. Faudone G, Zhubi R, Celik F, Knapp S, Chaikuad A, Heering J, Merk D. (2022) Design of a Potent TLX Agonist by Rational Fragment Fusion.. J Med Chem, 71 (13): (1755-70). [PMID:34989568] [10.1021/acs.jmedchem.1c01757]

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