Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C103231-250mg | 250mg | In stock | $10.90 | |
C103231-1g | 1g | In stock | $20.90 | |
C103231-5g | 5g | In stock | $40.90 | |
C103231-25g | 25g | In stock | $158.90 | |
C103231-100g | 100g | In stock | $570.90 |
Adenosine agonist
Synonyms | CADO | EINECS 205-678-3 | (2R,3R,4S,5R)-2-(6-Amino-2-chloro-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | BDBM50009525 | NCGC00021540-04 | 2-chloro[3h]adenosine | SCHEMBL104094 | HMS2235K11 | PDSP1_001209 | CCG-101063 | Opera_ID_460 | 2-Chloroad |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Adenosine receptor agonist. Metabolically stable analogue of adenosine. Anticonvulsant effects and neuroprotective in vivo . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of A 1 receptor;Agonist of A 2A receptor;Agonist of A 2B receptor;Agonist of A 3 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
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INCHI | InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1 |
InChi Key | BIXYYZIIJIXVFW-UUOKFMHZSA-N |
Canonical SMILES | C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)Cl)N |
Isomeric SMILES | C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)Cl)N |
WGK Germany | 3 |
RTECS | AU7357550 |
PubChem CID | 8974 |
Molecular Weight | 301.69 |
Beilstein | 43957 |
Reaxy-Rn | 43957 |
PubChem CID | 8974 |
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ChEMBL Ligand | CHEMBL285819 |
BindingDB Ligand | 50335299 |
CAS Registry No. | 146-77-0 |
GPCRdb Ligand | 2-chloroadenosine |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J1421010 | Certificate of Analysis | Jul 20, 2022 | C103231 |
I2203067 | Certificate of Analysis | Jun 30, 2022 | C103231 |
I2203069 | Certificate of Analysis | Jun 30, 2022 | C103231 |
B2212291 | Certificate of Analysis | Jan 03, 2022 | C103231 |
B2212294 | Certificate of Analysis | Jan 03, 2022 | C103231 |
B2212295 | Certificate of Analysis | Jan 03, 2022 | C103231 |
B2212296 | Certificate of Analysis | Jan 03, 2022 | C103231 |
B2212298 | Certificate of Analysis | Jan 03, 2022 | C103231 |
Solubility | Soluble in water. |
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Specific Rotation[α] | [α]D -50° (C=0.1,H2O) |
Melt Point(°C) | 162 °C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H360:May damage fertility or the unborn child H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | AU7357550 |
Reaxy-Rn | 43957 |
1. Guangrong Sun, Pei Guo, Han Yeong Kaw, Meijiao Zhou, Wei Wang. (2023) Uncovering an Emerging Group of Halogenated Nucleobase-Derived Disinfection Byproducts in Drinking Water: Prioritization of the Highly Cytotoxic 2-Chloroadenine. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (23): (8768–8775). [PMID:37232460] [10.1021/acs.est.3c01484] |
1. Di Angelantonio S et al.. (2011) Adenosine A2A receptor induces protein kinase A-dependent functional modulation of human (alpha)3(beta)4 nicotinic receptor.. J Physiol, 589 (Pt 11): (2755-66). [PMID:21486776] |
2. Elmasri M et al.. (2022) Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A.. Commun Biol, 5 (174). [PMID:35228668] |
3. Guangrong Sun, Pei Guo, Han Yeong Kaw, Meijiao Zhou, Wei Wang. (2023) Uncovering an Emerging Group of Halogenated Nucleobase-Derived Disinfection Byproducts in Drinking Water: Prioritization of the Highly Cytotoxic 2-Chloroadenine. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (23): (8768–8775). [PMID:37232460] [10.1021/acs.est.3c01484] |