2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomer
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
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2.Morein D et al.. (2021) Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.. Cells, 10 (6):[PMID:34072893]
3.Blancke Soares A et al.. (2021) High-resolution spatiotemporal pHe and pO2 imaging in head and neck and oesophageal carcinoma cells.. Cancer Metab, 9 (21). [PMID:33947450]
4.Wang Z et al.. (2022) The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells.. Cancer Commun (Lond), 42 (3):(245-265). [PMID:35234370]
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H2430351
![2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (copy) - 97%, used for , CAS No. 186689-07-6, by Aladdin Scientific](https://media-prod.aladdinsci.com/media/catalog/product/cache/515ce11dbf2c7bc125424616eb49ad88/N/1/N121715.png)
![2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose](https://media-prod.aladdinsci.com/media/catalog/product/cache/515ce11dbf2c7bc125424616eb49ad88/N/5/N580276.png)
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