Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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D109194-1g | 1g | In stock | $58.90 | |
D109194-5g | 5g | In stock | $189.90 | |
D109194-25g | 25g | In stock | $855.90 | |
D109194-100g | 100g | In stock | $3,078.90 |
Non-metabolizable glucose analog and glycolytic inhibitor. Antitumor agent.
Synonyms | 5CFA0332-FB70-485D-A064-6C4C39E7CBA1 | 2 Deoxy D glucose | 2-DEOXY-D-GLUCOSE [HSDB] | EINECS 205-823-0 | 2-Deoxy-D-mannose | 2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose | 3,3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzouran-1-one | D-2-Deoxygl |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomer |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488187422 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187422 |
IUPAC Name | (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal |
INCHI | InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1 |
InChi Key | VRYALKFFQXWPIH-PBXRRBTRSA-N |
Canonical SMILES | C(C=O)C(C(C(CO)O)O)O |
Isomeric SMILES | C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O |
WGK Germany | 3 |
RTECS | MQ3325000 |
PubChem CID | 108223 |
Molecular Weight | 164.16 |
Beilstein | 1723331 |
Reaxy-Rn | 1723331 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2430351 | Certificate of Analysis | Aug 19, 2024 | D109194 |
H2430350 | Certificate of Analysis | Aug 19, 2024 | D109194 |
H2430349 | Certificate of Analysis | Aug 19, 2024 | D109194 |
H2430348 | Certificate of Analysis | Aug 19, 2024 | D109194 |
G2312775 | Certificate of Analysis | Jun 07, 2023 | D109194 |
I2418083 | Certificate of Analysis | Jun 07, 2023 | D109194 |
G2312792 | Certificate of Analysis | Jun 07, 2023 | D109194 |
G2312790 | Certificate of Analysis | Jun 07, 2023 | D109194 |
G2312784 | Certificate of Analysis | Jun 07, 2023 | D109194 |
G2312783 | Certificate of Analysis | Jun 07, 2023 | D109194 |
G2312782 | Certificate of Analysis | Jun 07, 2023 | D109194 |
D2408085 | Certificate of Analysis | Jun 07, 2023 | D109194 |
G2312774 | Certificate of Analysis | Jun 07, 2023 | D109194 |
F2312717 | Certificate of Analysis | May 15, 2023 | D109194 |
G2205112 | Certificate of Analysis | Jun 01, 2022 | D109194 |
G2205098 | Certificate of Analysis | Jun 01, 2022 | D109194 |
G2205097 | Certificate of Analysis | Jun 01, 2022 | D109194 |
G2205096 | Certificate of Analysis | Jun 01, 2022 | D109194 |
E2124231 | Certificate of Analysis | Mar 17, 2021 | D109194 |
E2124230 | Certificate of Analysis | Mar 17, 2021 | D109194 |
E2124150 | Certificate of Analysis | Mar 17, 2021 | D109194 |
Solubility | Soluble in water. |
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Specific Rotation[α] | 46.5 ° (C=1, H2O) |
Melt Point(°C) | 146-147°C |
WGK Germany | 3 |
---|---|
RTECS | MQ3325000 |
Reaxy-Rn | 1723331 |
Merck Index | 2904 |
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1. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang. (2024) Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis. Journal of the Mechanical Behavior of Biomedical Materials, 150 (106306). [PMID:38091923] [10.1016/j.jmbbm.2023.106306] |
2. Pengfei Sun, Wan Yang, Jiarong He, Liuliang He, Pengfei Chen, Wenjuan Xu, Qingming Shen, Daifeng Li, Quli Fan. (2023) Phenylboronic Acid-Modified Near-Infrared Region Ii Excitation Donor–Acceptor–Donor Molecule for 2-Deoxy-D-Glucose Improved Starvation/Chemo/Photothermal Combination Therapy. Advanced Healthcare Materials, (12): (2302099). [PMID:37666241] [10.1002/adhm.202302099] |
3. Yanzhi Xing, Yulong Xu, Yanna Lin, E Shuang, Han Leng, Jianhua Wang, Xuwei Chen. (2023) Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 640 (626). [PMID:36889060] [10.1016/j.jcis.2023.02.133] |
4. Guangyu Cheng, Lin Li, Qingjie Li, Shulin Lian, Hongbo Chu, Yunlu Ding, Chikun Li, Yan Leng. (2022) β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling. American Journal of Cancer Research, 12 (4): ( 1535–1555). [PMID:35530288] [PMID:35530288] |
5. Hui Chen, Han Zhang, Lixing Cao, Jinling Cui, Xuan Ma, Chong Zhao, Shutao Yin, Hongbo Hu. (2022) Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. Cancers, 14 (2): (345). [PMID:35053507] [10.3390/cancers14020345] |
6. Yeneng Dai, Zhiquan Sun, Honghai Zhao, Dashan Qi, Xiangyu Li, Diya Gao, Meixing Li, Quli Fan, Qingming Shen, Wei Huang. (2021) NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy. BIOMATERIALS, 275 (120935). [PMID:34116284] [10.1016/j.biomaterials.2021.120935] |
7. Yuping Wei, Caiying Zhang, Man Zhang, Qionghong Niu, Fengli Hui, Zi Liu, Xia Xu. (2021) Insight of Synergistic Effect between CPP and Cargo on the Facilitation Mechanisms of R7-PTX Translocation: Experiments and Molecular Simulations. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 161 (105790). [PMID:33689859] [10.1016/j.ejps.2021.105790] |
8. Yangke Wanyan, Xixi Xu, Kehang Liu, Huidan Zhang, Junai Zhen, Rong Zhang, Jumei Wen, Ping Liu, Yuqing Chen. (2020) 2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors. MOLECULES, 25 (23): (5778). [PMID:33297583] [10.3390/molecules25235778] |
9. Yan Zhiyu, Wu Xiangli, Zhao Mengran, Zhang Jinxia. (2020) Lactic acid accumulation under heat stress related to accelerated glycolysis and mitochondrial dysfunction inhibits the mycelial growth of Pleurotus ostreatus. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (15): (6767-6777). [PMID:32533305] [10.1007/s00253-020-10718-5] |
10. Chen Xiaolong, Hu Cuihua, Zhang Yanan, Hao Wenjing, He Xu, Li Qing, Huang Yuxi, Huang Yibing, Chen Yuxin. (2020) Anticancer Activity and Mechanism of Action of kla-TAT Peptide. International Journal of Peptide Research and Therapeutics, 26 (4): (2285-2296). [PMID:] [10.1007/s10989-020-10019-5] |
11. Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang. (2019) In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin. Toxins, 11 (7): (379). [PMID:31262018] [10.3390/toxins11070379] |
12. Shi Ning, Liu Qiying, Cen Hu, Ju Rongmei, He Xiong, Ma Longlong. (2020) Formation of humins during degradation of carbohydrates and furfural derivatives in various solvents. Biomass Conversion and Biorefinery, 10 (2): (277-287). [PMID:] [10.1007/s13399-019-00414-4] |
13. Liu Ru-Tao, Zhang Min, Yang Chun-Lin, Zhang Peng, Zhang Na, Du Tong, Ge Meng-Ru, Yue Long-Tao, Li Xiao-Li, Li Heng, Duan Rui-Sheng. (2018) Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis. Journal of Neuroinflammation, 15 (1): (1-13). [PMID:29467007] [10.1186/s12974-018-1095-7] |
14. Mingtong Ye, Sufan Wang, Ting Wan, Rui Jiang, Yun Qiu, Lei Pei, Nengzhi Pang, Yuanling Huang, Yufeng Huang, Zhenfeng Zhang, Lili Yang. (2017) Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer. Journal of Cancer, 8 (18): ( 3774–3784). [PMID:29151965] [10.7150/jca.21035] |
15. Yuping Wei, Liang Ma, Liang Zhang, Xia Xu. (2017) Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy. International Journal of Nanomedicine, 12 ( 7039–7051). [PMID:29026300] [10.2147/IJN.S144322] |
16. Xianzhi Qu, Jiyao Sheng, Luyan Shen, Jing Su, Yunjie Xu, Qi Xie, Yao Wu, Xuewen Zhang, Liankun Sun. (2017) Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS. PLoS One, 12 (3): (e0173712). [PMID:28301876] [10.1371/journal.pone.0173712] |
17. Quan-Xing Mao, Shuang E, Jun-Mei Xia, Ru-Sheng Song, Yang Shu, Xu-Wei Chen, Jian-Hua Wang. (2016) Hydrophobic Carbon Nanodots with Rapid Cell Penetrability and Tunable Photoluminescence Behavior for in Vitro and in Vivo Imaging. LANGMUIR, 32 (46): (12221–12229). [PMID:27805819] [10.1021/acs.langmuir.6b03331] |
18. Ming-Zhen Zhang, Yong Yu, Rong-Na Yu, Min Wan, Rong-Ying Zhang, Yuan-Di Zhao. (2013) Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide. Small, 9 (24): (4183-4193). [PMID:23828664] [10.1002/smll.201300994] |
19. Ling Jiang, Liying Zhu, Xian Xu, Ming Lin, Yanping Li, Xiaotong Li, Huaiyan Cui, He Huang. (2013) Bioproduction of hydrogen by simultaneous saccharification and fermentation of cassava starch with 2-deoxyglucose-resistant mutant strains of Clostridium tyrobutyricum. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 38 (6349). [PMID:] [10.1016/j.ijhydene.2013.02.109] |
20. Yuefang Deng, Shuang Li, Qing Xu, Min Gao, He Huang. (2012) Production of fumaric acid by simultaneous saccharification and fermentation of starchy materials with 2-deoxyglucose-resistant mutant strains of Rhizopus oryzae. BIORESOURCE TECHNOLOGY, 107 (363). [PMID:22217732] [10.1016/j.biortech.2011.11.117] |
1. Cabezas-Cruz A et al.. (2017) Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis.. Front Cell Infect Microbiol, 7 (23). [PMID:28229048] |
2. Morein D et al.. (2021) Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.. Cells, 10 (6): [PMID:34072893] |
3. Blancke Soares A et al.. (2021) High-resolution spatiotemporal pHe and pO2 imaging in head and neck and oesophageal carcinoma cells.. Cancer Metab, 9 (21). [PMID:33947450] |
4. Wang Z et al.. (2022) The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells.. Cancer Commun (Lond), 42 (3): (245-265). [PMID:35234370] |
5. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang. (2024) Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis. Journal of the Mechanical Behavior of Biomedical Materials, 150 (106306). [PMID:38091923] [10.1016/j.jmbbm.2023.106306] |
6. Pengfei Sun, Wan Yang, Jiarong He, Liuliang He, Pengfei Chen, Wenjuan Xu, Qingming Shen, Daifeng Li, Quli Fan. (2023) Phenylboronic Acid-Modified Near-Infrared Region Ii Excitation Donor–Acceptor–Donor Molecule for 2-Deoxy-D-Glucose Improved Starvation/Chemo/Photothermal Combination Therapy. Advanced Healthcare Materials, (12): (2302099). [PMID:37666241] [10.1002/adhm.202302099] |
7. Yanzhi Xing, Yulong Xu, Yanna Lin, E Shuang, Han Leng, Jianhua Wang, Xuwei Chen. (2023) Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 640 (626). [PMID:36889060] [10.1016/j.jcis.2023.02.133] |
8. Guangyu Cheng, Lin Li, Qingjie Li, Shulin Lian, Hongbo Chu, Yunlu Ding, Chikun Li, Yan Leng. (2022) β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling. American Journal of Cancer Research, 12 (4): ( 1535–1555). [PMID:35530288] [PMID:35530288] |
9. Hui Chen, Han Zhang, Lixing Cao, Jinling Cui, Xuan Ma, Chong Zhao, Shutao Yin, Hongbo Hu. (2022) Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. Cancers, 14 (2): (345). [PMID:35053507] [10.3390/cancers14020345] |
10. Yeneng Dai, Zhiquan Sun, Honghai Zhao, Dashan Qi, Xiangyu Li, Diya Gao, Meixing Li, Quli Fan, Qingming Shen, Wei Huang. (2021) NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy. BIOMATERIALS, 275 (120935). [PMID:34116284] [10.1016/j.biomaterials.2021.120935] |
11. Yuping Wei, Caiying Zhang, Man Zhang, Qionghong Niu, Fengli Hui, Zi Liu, Xia Xu. (2021) Insight of Synergistic Effect between CPP and Cargo on the Facilitation Mechanisms of R7-PTX Translocation: Experiments and Molecular Simulations. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 161 (105790). [PMID:33689859] [10.1016/j.ejps.2021.105790] |
12. Yangke Wanyan, Xixi Xu, Kehang Liu, Huidan Zhang, Junai Zhen, Rong Zhang, Jumei Wen, Ping Liu, Yuqing Chen. (2020) 2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors. MOLECULES, 25 (23): (5778). [PMID:33297583] [10.3390/molecules25235778] |
13. Yan Zhiyu, Wu Xiangli, Zhao Mengran, Zhang Jinxia. (2020) Lactic acid accumulation under heat stress related to accelerated glycolysis and mitochondrial dysfunction inhibits the mycelial growth of Pleurotus ostreatus. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (15): (6767-6777). [PMID:32533305] [10.1007/s00253-020-10718-5] |
14. Chen Xiaolong, Hu Cuihua, Zhang Yanan, Hao Wenjing, He Xu, Li Qing, Huang Yuxi, Huang Yibing, Chen Yuxin. (2020) Anticancer Activity and Mechanism of Action of kla-TAT Peptide. International Journal of Peptide Research and Therapeutics, 26 (4): (2285-2296). [PMID:] [10.1007/s10989-020-10019-5] |
15. Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang. (2019) In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin. Toxins, 11 (7): (379). [PMID:31262018] [10.3390/toxins11070379] |
16. Shi Ning, Liu Qiying, Cen Hu, Ju Rongmei, He Xiong, Ma Longlong. (2020) Formation of humins during degradation of carbohydrates and furfural derivatives in various solvents. Biomass Conversion and Biorefinery, 10 (2): (277-287). [PMID:] [10.1007/s13399-019-00414-4] |
17. Liu Ru-Tao, Zhang Min, Yang Chun-Lin, Zhang Peng, Zhang Na, Du Tong, Ge Meng-Ru, Yue Long-Tao, Li Xiao-Li, Li Heng, Duan Rui-Sheng. (2018) Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis. Journal of Neuroinflammation, 15 (1): (1-13). [PMID:29467007] [10.1186/s12974-018-1095-7] |
18. Mingtong Ye, Sufan Wang, Ting Wan, Rui Jiang, Yun Qiu, Lei Pei, Nengzhi Pang, Yuanling Huang, Yufeng Huang, Zhenfeng Zhang, Lili Yang. (2017) Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer. Journal of Cancer, 8 (18): ( 3774–3784). [PMID:29151965] [10.7150/jca.21035] |
19. Yuping Wei, Liang Ma, Liang Zhang, Xia Xu. (2017) Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy. International Journal of Nanomedicine, 12 ( 7039–7051). [PMID:29026300] [10.2147/IJN.S144322] |
20. Xianzhi Qu, Jiyao Sheng, Luyan Shen, Jing Su, Yunjie Xu, Qi Xie, Yao Wu, Xuewen Zhang, Liankun Sun. (2017) Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS. PLoS One, 12 (3): (e0173712). [PMID:28301876] [10.1371/journal.pone.0173712] |
21. Quan-Xing Mao, Shuang E, Jun-Mei Xia, Ru-Sheng Song, Yang Shu, Xu-Wei Chen, Jian-Hua Wang. (2016) Hydrophobic Carbon Nanodots with Rapid Cell Penetrability and Tunable Photoluminescence Behavior for in Vitro and in Vivo Imaging. LANGMUIR, 32 (46): (12221–12229). [PMID:27805819] [10.1021/acs.langmuir.6b03331] |
22. Ming-Zhen Zhang, Yong Yu, Rong-Na Yu, Min Wan, Rong-Ying Zhang, Yuan-Di Zhao. (2013) Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide. Small, 9 (24): (4183-4193). [PMID:23828664] [10.1002/smll.201300994] |
23. Ling Jiang, Liying Zhu, Xian Xu, Ming Lin, Yanping Li, Xiaotong Li, Huaiyan Cui, He Huang. (2013) Bioproduction of hydrogen by simultaneous saccharification and fermentation of cassava starch with 2-deoxyglucose-resistant mutant strains of Clostridium tyrobutyricum. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 38 (6349). [PMID:] [10.1016/j.ijhydene.2013.02.109] |
24. Yuefang Deng, Shuang Li, Qing Xu, Min Gao, He Huang. (2012) Production of fumaric acid by simultaneous saccharification and fermentation of starchy materials with 2-deoxyglucose-resistant mutant strains of Rhizopus oryzae. BIORESOURCE TECHNOLOGY, 107 (363). [PMID:22217732] [10.1016/j.biortech.2011.11.117] |