2′-Deoxyguanosine hydrate - 10mM in DMSO, high purity , CAS No.961-07-9

  • 10mM in DMSO
Item Number
D427161
Grouped product items
SKUSizeAvailabilityPrice Qty
D427161-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$59.90

Purine nucleoside.

Basic Description

Synonyms2'-deoxyguanosine | deoxyguanosine | 961-07-9 | Guanosine, 2'-deoxy- | 2-Deoxyguanosine | Guanine deoxy nucleoside | Guanine deoxyriboside | 2'-DEOXY-GUANOSINE | 2(acute)-Deoxyguanosine | 663615-45-0 | 2'-Desoxyguanosine | 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetra
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsPurine nucleoside that upon sequential phosphoylation forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesise DNA.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

DCK Tchem Deoxycytidine kinase (530 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK1 Tchem Thymidine kinase, cytosolic (627 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-HSB-2 (188 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MT4 (17854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HaCaT (4069 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pnp Purine nucleoside phosphorylase (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 2 (4932 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 3 (4092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human betaherpesvirus 5 (5122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 1 (11089 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L6 (7924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dgk Deoxyguanosine kinase (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
INCHI InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
InChi Key YKBGVTZYEHREMT-KVQBGUIXSA-N
Canonical SMILES C1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)CO)O
Isomeric SMILES C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)CO)O
WGK Germany 3
RTECS MF8760000
Alternate CAS 207121-55-9
PubChem CID 135398592
Molecular Weight 267.24(anhydrous basis)
Reaxy-Rn 760398

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Sensitivityair sensitive;Moisture sensitive
Specific Rotation[α]-42 ° (C=0.2, 1mol/L NaOH)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RTECS MF8760000
Reaxy-Rn 760398

Related Documents

Citations of This Product

1. Wenqing Wang, Hao Li, Meiyao Li, Huiling Lu, Jianming Pan.  (2024)  Layer-by-layer assembled magnetic molecularly imprinted nanoparticles for highly specific separation of adenosine 5′-monophosphate: Relations between adsorption properties and imprinted layers.  SEPARATION AND PURIFICATION TECHNOLOGY,  330  (125346).  [PMID:15220430] [10.1016/j.seppur.2023.125346]
2. Qiangqiang Jia, Zufan Yang, Qian Wang, Haishan Yang, Xiaofeng Tang, Hongyang Zhang, Lingling Cao, Gong Zhang.  (2023)  A liquid chromatography-tandem mass spectrometry method for comprehensive determination of metabolites in the purine pathway of rat plasma and its application in anti-gout effects of Lycium ruthenicum Murr..  JOURNAL OF SEPARATION SCIENCE,  46  (21): (2300090).  [PMID:37688342] [10.1002/jssc.202300090]
3. Xu Lian, Li Hui-Min, Lin Juan.  (2023)  Efficient synthesis of 2’-deoxyguanosine in one-pot cascade by employing an engineered purine nucleoside phosphorylase from Brevibacterium acetylicum.  WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,  39  (10): (1-9).  [PMID:37606812] [10.1007/s11274-023-03721-1]
4. Meiyao Li, Pan Wang, Shunshun Luo, Yu Wu, Xiaohua Tian, Jianming Pan.  (2023)  Construction of anti-biofouling imprinted sorbents based on anisotropic polydopamine nanotubes for fast and selective capture of 2′-deoxyadenosine.  SEPARATION AND PURIFICATION TECHNOLOGY,  312  (123384).  [PMID:] [10.1016/j.seppur.2023.123384]
5. Zhuangxin Wei, Pan Wang, Xiaohua Tian, Wei sun, Jianming Pan.  (2022)  Imprinted polymer beads featuring both predefined multiple-point interaction and accessible binding sites for precise recognition of 2′-deoxyadenosine.  SEPARATION AND PURIFICATION TECHNOLOGY,  302  (122048).  [PMID:] [10.1016/j.seppur.2022.122048]
6. Xin Wen, Huahua Fan, Lihong Jing, Ming Deng, Xiaodan Huang, Tifeng Jiao, Li Zhang, Minghua Liu.  (2022)  Competitive induction of circularly polarized luminescence of CdSe/ZnS quantum dots in a nucleotide–amino acid hydrogel.  Materials Advances,  (1): (682-688).  [PMID:] [10.1039/D1MA00843A]
7. Chang Xiangwei, Zhang Zhenyu, Yan Hui, Su Shulan, Wei Dandan, Guo Sheng, Shang Erxin, Sun Xiaodong, Gui Shuangying, Duan Jinao.  (2021)  Discovery of Quality Markers of Nucleobases, Nucleosides, Nucleotides and Amino Acids for Chrysanthemi Flos From Different Geographical Origins Using UPLC–MS/MS Combined With Multivariate Statistical Analysis.  Frontiers in Chemistry,    [PMID:34422760] [10.3389/fchem.2021.689254]
8. Jia Ding, Fei Liu, Chunling Qi, Yunlei Zhou, Huanshun Yin, Shiyun Ai.  (2021)  Enhanced photoactivity of perovskite Bi4NbO8Cl/PTC-NH2 heterojunction and its application for photoelectrochemical sensing of DNA hydroxymethylation.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130211).  [PMID:] [10.1016/j.snb.2021.130211]
9. Ji-shuo Chang, Zhong-xiao Lin, Ya-juan Liu, Si-ming Yang, Yu Zhang, Xi-yong Yu.  (2021)  Ultra performance liquid chromatography–tandem mass spectrometry assay for the quantification of RNA and DNA methylation.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  197  (113969).  [PMID:33636646] [10.1016/j.jpba.2021.113969]
10. Shuangshou Wang, Zhendong He, Wenzhi Li, Jiayi Zhao, Tong Chen, Shimin Shao, Hongmei Chen.  (2020)  Reshaping of pipette tip: A facile and practical strategy for sorbent packing-free solid phase extraction.  ANALYTICA CHIMICA ACTA,  1100  (47).  [PMID:31987152] [10.1016/j.aca.2019.11.060]
11. Yuanyuan Xu, Yue Yang, Aifang Xue, Hao Chen, Shengqing Li.  (2018)  In situ precipitation of hydrous titanium dioxide for dispersive micro solid-phase extraction of nucleosides and their separation.  NEW JOURNAL OF CHEMISTRY,  42  (7): (4909-4914).  [PMID:] [10.1039/C7NJ04590E]
12. Chaozhan Wang, Huanhuan Xu, Yinmao Wei.  (2016)  The preparation of high-capacity boronate affinity adsorbents by surface initiated reversible addition fragmentation chain transfer polymerization for the enrichment of ribonucleosides in serum.  ANALYTICA CHIMICA ACTA,  902  (115).  [PMID:26703260] [10.1016/j.aca.2015.11.013]
13. Hengye Li,Xuemeng Zhang,Lin Zhang,Hui Cang,Fenying Kong,Dahe Fan,Wei Wang.  (2018-04-13)  Hyperbranched Polyglycerol Functionalized Silica Stationary Phase for Hydrophilic Interaction Liquid Chromatography..  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,  34  ((4)): (433-438).  [PMID:29643306]

References

1. Wenqing Wang, Hao Li, Meiyao Li, Huiling Lu, Jianming Pan.  (2024)  Layer-by-layer assembled magnetic molecularly imprinted nanoparticles for highly specific separation of adenosine 5′-monophosphate: Relations between adsorption properties and imprinted layers.  SEPARATION AND PURIFICATION TECHNOLOGY,  330  (125346).  [PMID:15220430] [10.1016/j.seppur.2023.125346]
2. Qiangqiang Jia, Zufan Yang, Qian Wang, Haishan Yang, Xiaofeng Tang, Hongyang Zhang, Lingling Cao, Gong Zhang.  (2023)  A liquid chromatography-tandem mass spectrometry method for comprehensive determination of metabolites in the purine pathway of rat plasma and its application in anti-gout effects of Lycium ruthenicum Murr..  JOURNAL OF SEPARATION SCIENCE,  46  (21): (2300090).  [PMID:37688342] [10.1002/jssc.202300090]
3. Xu Lian, Li Hui-Min, Lin Juan.  (2023)  Efficient synthesis of 2’-deoxyguanosine in one-pot cascade by employing an engineered purine nucleoside phosphorylase from Brevibacterium acetylicum.  WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,  39  (10): (1-9).  [PMID:37606812] [10.1007/s11274-023-03721-1]
4. Meiyao Li, Pan Wang, Shunshun Luo, Yu Wu, Xiaohua Tian, Jianming Pan.  (2023)  Construction of anti-biofouling imprinted sorbents based on anisotropic polydopamine nanotubes for fast and selective capture of 2′-deoxyadenosine.  SEPARATION AND PURIFICATION TECHNOLOGY,  312  (123384).  [PMID:] [10.1016/j.seppur.2023.123384]
5. Zhuangxin Wei, Pan Wang, Xiaohua Tian, Wei sun, Jianming Pan.  (2022)  Imprinted polymer beads featuring both predefined multiple-point interaction and accessible binding sites for precise recognition of 2′-deoxyadenosine.  SEPARATION AND PURIFICATION TECHNOLOGY,  302  (122048).  [PMID:] [10.1016/j.seppur.2022.122048]
6. Xin Wen, Huahua Fan, Lihong Jing, Ming Deng, Xiaodan Huang, Tifeng Jiao, Li Zhang, Minghua Liu.  (2022)  Competitive induction of circularly polarized luminescence of CdSe/ZnS quantum dots in a nucleotide–amino acid hydrogel.  Materials Advances,  (1): (682-688).  [PMID:] [10.1039/D1MA00843A]
7. Chang Xiangwei, Zhang Zhenyu, Yan Hui, Su Shulan, Wei Dandan, Guo Sheng, Shang Erxin, Sun Xiaodong, Gui Shuangying, Duan Jinao.  (2021)  Discovery of Quality Markers of Nucleobases, Nucleosides, Nucleotides and Amino Acids for Chrysanthemi Flos From Different Geographical Origins Using UPLC–MS/MS Combined With Multivariate Statistical Analysis.  Frontiers in Chemistry,    [PMID:34422760] [10.3389/fchem.2021.689254]
8. Jia Ding, Fei Liu, Chunling Qi, Yunlei Zhou, Huanshun Yin, Shiyun Ai.  (2021)  Enhanced photoactivity of perovskite Bi4NbO8Cl/PTC-NH2 heterojunction and its application for photoelectrochemical sensing of DNA hydroxymethylation.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130211).  [PMID:] [10.1016/j.snb.2021.130211]
9. Ji-shuo Chang, Zhong-xiao Lin, Ya-juan Liu, Si-ming Yang, Yu Zhang, Xi-yong Yu.  (2021)  Ultra performance liquid chromatography–tandem mass spectrometry assay for the quantification of RNA and DNA methylation.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  197  (113969).  [PMID:33636646] [10.1016/j.jpba.2021.113969]
10. Shuangshou Wang, Zhendong He, Wenzhi Li, Jiayi Zhao, Tong Chen, Shimin Shao, Hongmei Chen.  (2020)  Reshaping of pipette tip: A facile and practical strategy for sorbent packing-free solid phase extraction.  ANALYTICA CHIMICA ACTA,  1100  (47).  [PMID:31987152] [10.1016/j.aca.2019.11.060]
11. Yuanyuan Xu, Yue Yang, Aifang Xue, Hao Chen, Shengqing Li.  (2018)  In situ precipitation of hydrous titanium dioxide for dispersive micro solid-phase extraction of nucleosides and their separation.  NEW JOURNAL OF CHEMISTRY,  42  (7): (4909-4914).  [PMID:] [10.1039/C7NJ04590E]
12. Chaozhan Wang, Huanhuan Xu, Yinmao Wei.  (2016)  The preparation of high-capacity boronate affinity adsorbents by surface initiated reversible addition fragmentation chain transfer polymerization for the enrichment of ribonucleosides in serum.  ANALYTICA CHIMICA ACTA,  902  (115).  [PMID:26703260] [10.1016/j.aca.2015.11.013]
13. Hengye Li,Xuemeng Zhang,Lin Zhang,Hui Cang,Fenying Kong,Dahe Fan,Wei Wang.  (2018-04-13)  Hyperbranched Polyglycerol Functionalized Silica Stationary Phase for Hydrophilic Interaction Liquid Chromatography..  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,  34  ((4)): (433-438).  [PMID:29643306]

Solution Calculators