Grouped product items

SKU

Size

Availability

Price

Qty

D100363-1g

In stock

$48.90

D100363-5g

In stock

$188.90

D100363-10g

10g

In stock

$338.90

D100363-25g

25g

In stock

$443.90

D100363-100g

100g

In stock

$1,597.90

D100363-500g

500g

Available within 4-8 weeks(?)

$7,187.90

Basic Description

Synonyms	1-(2-deoxy-beta-D-erythro-pentofuranosyl)uracil \| s5505 \| MLS001066344 \| bmse000320 \| SCHEMBL28844 \| 1-(2-Deoxy-ss-D-ribofuranosyl)uracil \| 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione \| CCRIS 2832 \| 1-[(2R,4S,5R)-4-hydroxy-5-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Pyrimidine 2'-deoxyribonucleoside. Frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Application： 2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2?-Deoxyuridines used as labeling substrates include chloro-2-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2-deoxyuridine include 5-ethynyl-2-deoxyuridine (DdU) and 5-hydroxymethyl-2-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Associated Targets(Human)

POLB Tchem DNA polymerase beta (0 Activities)

Discover Target: POLB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DCK Tchem Deoxycytidine kinase (0 Activities)

Discover Target: DCK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TYMP Tclin Thymidine phosphorylase (0 Activities)

Discover Target: TYMP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TK1 Tchem Thymidine kinase, cytosolic (0 Activities)

Discover Target: TK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B (0 Activities)

Discover Target: MAOB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A (0 Activities)

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TK2 Tchem Thymidine kinase 2, mitochondrial (0 Activities)

Discover Target: TK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDC25B Tchem M-phase inducer phosphatase 2 (0 Activities)

Discover Target: CDC25B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DCK Tchem Deoxycytidine kinase (530 Activities)

Discover Target: DCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TK1 Tchem Thymidine kinase, cytosolic (627 Activities)

Discover Target: TK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A2780 (11979 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

TK Thymidine kinase (276 Activities)

Discover Target: TK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

deoA Thymidine phosphorylase (531 Activities)

Discover Target: deoA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)

Discover Target: Cdc25b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tk2 Thymidine kinase 2 (53 Activities)

Discover Target: Tk2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecium (13803 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis B virus (7925 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488181894
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181894
IUPAC Name	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
INCHI	InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
InChi Key	MXHRCPNRJAMMIM-SHYZEUOFSA-N
Canonical SMILES	C1C(C(OC1N2C=CC(=O)NC2=O)CO)O
Isomeric SMILES	C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O
WGK Germany	3
RTECS	YU7490000
PubChem CID	13712
Molecular Weight	228.2
Beilstein	24433
Reaxy-Rn	24433

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

39 results found

Lot Number	Certificate Type	Date	Item
K2429510	Certificate of Analysis	Nov 15, 2024	D100363
K2429478	Certificate of Analysis	Nov 15, 2024	D100363
K2429477	Certificate of Analysis	Nov 15, 2024	D100363
G2405353	Certificate of Analysis	Jun 21, 2024	D100363
G2405354	Certificate of Analysis	Jun 21, 2024	D100363
F2412190	Certificate of Analysis	Mar 26, 2024	D100363
F2412189	Certificate of Analysis	Mar 26, 2024	D100363
E2406389	Certificate of Analysis	Mar 26, 2024	D100363
K2321145	Certificate of Analysis	Jul 12, 2023	D100363
K2321144	Certificate of Analysis	Jul 12, 2023	D100363
K2321146	Certificate of Analysis	Jul 12, 2023	D100363
F2316677	Certificate of Analysis	Jun 01, 2023	D100363
F2316681	Certificate of Analysis	Jun 01, 2023	D100363
F2316680	Certificate of Analysis	Jun 01, 2023	D100363
F2316679	Certificate of Analysis	Jun 01, 2023	D100363
F2316678	Certificate of Analysis	Jun 01, 2023	D100363
F2316676	Certificate of Analysis	Jun 01, 2023	D100363
A2306521	Certificate of Analysis	Nov 12, 2022	D100363
A2306519	Certificate of Analysis	Nov 12, 2022	D100363
A2306561	Certificate of Analysis	Nov 12, 2022	D100363
A2306562	Certificate of Analysis	Nov 12, 2022	D100363
A2306624	Certificate of Analysis	Nov 12, 2022	D100363
A2306671	Certificate of Analysis	Nov 12, 2022	D100363
A2306677	Certificate of Analysis	Nov 12, 2022	D100363
A2306683	Certificate of Analysis	Nov 12, 2022	D100363
A2306678	Certificate of Analysis	Nov 12, 2022	D100363
J2209280	Certificate of Analysis	Jul 22, 2022	D100363
J2209279	Certificate of Analysis	Jul 22, 2022	D100363
J2209087	Certificate of Analysis	Jul 22, 2022	D100363
J2209088	Certificate of Analysis	Jul 22, 2022	D100363
J1428007	Certificate of Analysis	Jun 23, 2022	D100363
F2222331	Certificate of Analysis	Jun 02, 2022	D100363
F2222318	Certificate of Analysis	Jun 02, 2022	D100363
F2222321	Certificate of Analysis	Jun 02, 2022	D100363
C1812214	Certificate of Analysis	Jan 24, 2022	D100363
C1812216	Certificate of Analysis	Jan 24, 2022	D100363
B2207270	Certificate of Analysis	Dec 28, 2021	D100363
B2207272	Certificate of Analysis	Dec 28, 2021	D100363
B2207274	Certificate of Analysis	Dec 28, 2021	D100363

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Chemical and Physical Properties

Solubility	Soluble in water.
Sensitivity	Air Sensitive
Specific Rotation[α]	52 ° (C=1, 1mol/L NaOH)
Melt Point(°C)	160-168°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	YU7490000
Reaxy-Rn	24433
Merck Index	2910

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Qiuhua Zhang, Lingyi Huang, Youjia Wu, Liying Huang, Xiaowen Xu, Renyi Lin. (2022) Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography–Tandem Mass Spectrometry. MOLECULES, 27 (13): (4130). [PMID:35807378] [10.3390/molecules27134130]
2. Gaofei Liu, Xin Tong, Jialing Wang, Bin Wu, Jianlin Chu, Yongchan Jian, Bingfang He. (2021) Reshaping the binding pocket of purine nucleoside phosphorylase for improved production of 2-halogenated-2′-deoxyadenosines. Catalysis Science & Technology, 11 (13): (4439-4446). [PMID:] [10.1039/D0CY02424D]
3. Wang Xue-Jie, You Jin-Zong. (2015) Study on the molecular structure and thermal stability of pyrimidine nucleoside analogs. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 120 (1): (1009-1025). [PMID:] [10.1007/s10973-014-4362-6]
4. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao. (2017-03-28) Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease.. Redox biology, 12 (505-521). [PMID:28343144]
5. Hengye Li,Xuemeng Zhang,Lin Zhang,Hui Cang,Fenying Kong,Dahe Fan,Wei Wang. (2018-04-13) Hyperbranched Polyglycerol Functionalized Silica Stationary Phase for Hydrophilic Interaction Liquid Chromatography.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 34 ((4)): (433-438). [PMID:29643306]

References

1. Qiuhua Zhang, Lingyi Huang, Youjia Wu, Liying Huang, Xiaowen Xu, Renyi Lin. (2022) Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography–Tandem Mass Spectrometry. MOLECULES, 27 (13): (4130). [PMID:35807378] [10.3390/molecules27134130]
2. Gaofei Liu, Xin Tong, Jialing Wang, Bin Wu, Jianlin Chu, Yongchan Jian, Bingfang He. (2021) Reshaping the binding pocket of purine nucleoside phosphorylase for improved production of 2-halogenated-2′-deoxyadenosines. Catalysis Science & Technology, 11 (13): (4439-4446). [PMID:] [10.1039/D0CY02424D]
3. Wang Xue-Jie, You Jin-Zong. (2015) Study on the molecular structure and thermal stability of pyrimidine nucleoside analogs. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 120 (1): (1009-1025). [PMID:] [10.1007/s10973-014-4362-6]
4. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao. (2017-03-28) Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease.. Redox biology, 12 (505-521). [PMID:28343144]
5. Hengye Li,Xuemeng Zhang,Lin Zhang,Hui Cang,Fenying Kong,Dahe Fan,Wei Wang. (2018-04-13) Hyperbranched Polyglycerol Functionalized Silica Stationary Phase for Hydrophilic Interaction Liquid Chromatography.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 34 ((4)): (433-438). [PMID:29643306]

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2'-Deoxyuridine - 99%, high purity , CAS No.951-78-0

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator