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D427065-1ml

1ml

Available within 4-8 weeks(?)

$43.90

Basic Description

Synonyms	2'-DEOXYURIDINE \| 951-78-0 \| deoxyuridine \| Uracil deoxyriboside \| 2-Deoxyuridine \| 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione \| Uridine, 2'-deoxy- \| Deoxyribose uracil \| 2'-Desoxyuridine \| dURD \| 2'-Deoxyuridine-1'-d \| 1-(2-Deoxy
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Pyrimidine 2'-deoxyribonucleoside. Frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

POLB Tchem DNA polymerase beta (0 Activities)

Discover Target: POLB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DCK Tchem Deoxycytidine kinase (0 Activities)

Discover Target: DCK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TYMP Tclin Thymidine phosphorylase (0 Activities)

Discover Target: TYMP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TK1 Tchem Thymidine kinase, cytosolic (0 Activities)

Discover Target: TK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B (0 Activities)

Discover Target: MAOB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A (0 Activities)

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TK2 Tchem Thymidine kinase 2, mitochondrial (0 Activities)

Discover Target: TK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDC25B Tchem M-phase inducer phosphatase 2 (0 Activities)

Discover Target: CDC25B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DCK Tchem Deoxycytidine kinase (530 Activities)

Discover Target: DCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TK1 Tchem Thymidine kinase, cytosolic (627 Activities)

Discover Target: TK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A2780 (11979 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

TK Thymidine kinase (276 Activities)

Discover Target: TK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

deoA Thymidine phosphorylase (531 Activities)

Discover Target: deoA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)

Discover Target: Cdc25b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tk2 Thymidine kinase 2 (53 Activities)

Discover Target: Tk2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecium (13803 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis B virus (7925 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bifunctional dihydrofolate reductase-thymidylate synthase (22 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
INCHI	InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
InChi Key	MXHRCPNRJAMMIM-SHYZEUOFSA-N
Canonical SMILES	C1C(C(OC1N2C=CC(=O)NC2=O)CO)O
Isomeric SMILES	C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O
WGK Germany	3
RTECS	YU7490000
PubChem CID	13712
Molecular Weight	228.2
Beilstein	24433
Reaxy-Rn	24433

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Air Sensitive
Specific Rotation[α]	52 ° (C=1, 1mol/L NaOH)
Melt Point(°C)	160-168°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	YU7490000
Reaxy-Rn	24433
Merck Index	2910

Citations of This Product

1. Qiuhua Zhang, Lingyi Huang, Youjia Wu, Liying Huang, Xiaowen Xu, Renyi Lin. (2022) Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography–Tandem Mass Spectrometry. MOLECULES, 27 (13): (4130). [PMID:35807378]
2. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao. (2017-03-28) Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease.. Redox biology, 12 (505-521). [PMID:28343144]
3. Hengye Li,Xuemeng Zhang,Lin Zhang,Hui Cang,Fenying Kong,Dahe Fan,Wei Wang. (2018-04-13) Hyperbranched Polyglycerol Functionalized Silica Stationary Phase for Hydrophilic Interaction Liquid Chromatography.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 34 ((4)): (433-438). [PMID:29643306]

References

1. Qiuhua Zhang, Lingyi Huang, Youjia Wu, Liying Huang, Xiaowen Xu, Renyi Lin. (2022) Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography–Tandem Mass Spectrometry. MOLECULES, 27 (13): (4130). [PMID:35807378]
2. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao. (2017-03-28) Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease.. Redox biology, 12 (505-521). [PMID:28343144]
3. Hengye Li,Xuemeng Zhang,Lin Zhang,Hui Cang,Fenying Kong,Dahe Fan,Wei Wang. (2018-04-13) Hyperbranched Polyglycerol Functionalized Silica Stationary Phase for Hydrophilic Interaction Liquid Chromatography.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 34 ((4)): (433-438). [PMID:29643306]

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2'-Deoxyuridine - 10mM in DMSO, high purity , CAS No.951-78-0