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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H108693-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
H108693-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $11.90 | |
H108693-25g | 25g | In stock | $22.90 | |
H108693-100g | 100g | In stock | $82.90 | |
H108693-250g | 250g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $113.90 | |
H108693-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $203.90 |
Synonyms | 2-HYDROXYPYRIDINE | Pyridin-2-ol | 142-08-5 | 2-Pyridone | 2-Pyridinol | 72762-00-6 | pyridin-2(1H)-one | 2(1H)-Pyridinone | 1H-pyridin-2-one | 2-Pyridinone | 2(1H)-Pyridone | Pyridinone | alpha-Pyridone | 2-Oxopyridine | pyridin-2-one | Pyridone-2 | 2-hydroxy pyridine | .alpha.-Pyridone | |
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Specifications & Purity | ≥97% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 1H-pyridin-2-one |
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INCHI | InChI=1S/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7) |
InChi Key | UBQKCCHYAOITMY-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=O)NC=C1 |
Isomeric SMILES | C1=CC(=O)NC=C1 |
WGK Germany | 3 |
RTECS | UV1144050 |
Alternate CAS | 72762-00-6 |
PubChem CID | 8871 |
Molecular Weight | 95.1 |
Beilstein | 105757 |
Reaxy-Rn | 105757 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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G2022041 | Certificate of Analysis | May 08, 2024 | H108693 |
D2415428 | Certificate of Analysis | Nov 07, 2022 | H108693 |
G2303606 | Certificate of Analysis | Nov 07, 2022 | H108693 |
L2215523 | Certificate of Analysis | Nov 07, 2022 | H108693 |
L2215557 | Certificate of Analysis | Nov 07, 2022 | H108693 |
L2215563 | Certificate of Analysis | Nov 07, 2022 | H108693 |
L2215566 | Certificate of Analysis | Nov 07, 2022 | H108693 |
L2215642 | Certificate of Analysis | Nov 07, 2022 | H108693 |
B2209122 | Certificate of Analysis | Feb 16, 2022 | H108693 |
Solubility | Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether. |
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Sensitivity | Light sensitive. |
Flash Point(°C) | 210°C |
Boil Point(°C) | 280-281°C |
Melt Point(°C) | 106-107°C |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P302+P352:IF ON SKIN: wash with plenty of water. P337+P313:IF eye irritation persists: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. |
WGK Germany | 3 |
RTECS | UV1144050 |
Reaxy-Rn | 105757 |
1. Zengchao Guo, Jiang Xiao, Weiwei Liu, Yihan Wang, Tengfei Liu, Hui Jiang, Xiaohui Liu, Xuemei Wang. (2023) Cationic porphyrin-based nanoparticles assisted with bio-assembly imaging-guided strategy for efficient inactivation of bacteria and promote wound healing. CHEMICAL ENGINEERING JOURNAL, 457 (141218). [PMID:] |
2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] |
1. Marie A Colucci,Philip Reigan,David Siegel,Aurélie Chilloux,David Ross,Christopher J Moody. (2007-10-20) Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.. Journal of medicinal chemistry, 50 ((23)): (5780-5789). [PMID:17944451] |
2. Ming Yang,Łukasz Szyc,Jens Dreyer,Erik T J Nibbering,Thomas Elsaesser. (2010-11-03) The hydrogen-bonded 2-pyridone dimer model system. 2. Femtosecond mid-infrared pump-probe study.. The journal of physical chemistry. A, 114 ((46)): (12195-12201). [PMID:21038900] |
3. Ning-Ning Wei,Ce Hao,Jiao-Jie Tan,Guangyan Zhao,Ruizhou Li,Zhilong Xiu,Jieshan Qiu. (2010-11-26) Time-dependent density functional theory study of the excited-state dihydrogen bonding: clusters of 2-pyridone with diethylmethylsilane and triethylgermanium.. Journal of molecular modeling, 17 ((8)): (1891-1897). [PMID:21107624] |
4. Borys Ośmiałowski,Robert Dobosz. (2011-01-05) The influence of secondary interactions on complex stability and double proton transfer reaction in 2-[1H]-pyridone/2-hydroxypyridine dimers.. Journal of molecular modeling, 17 ((10)): (2491-2500). [PMID:21193938] |
5. Radek Šachl,Erik Rosenbaum,Magnus Sellstedt,Fredrik Almqvist,Lennart B-Å Johansson. (2011-01-08) Locations and reorientations of multi-ring-fused 2-pyridones in ganglioside G(M1) micelles.. Langmuir : the ACS journal of surfaces and colloids, 27 ((5)): (1662-1667). [PMID:21210677] |
6. Shreekant Deshpande,Rinki Singh,Mohammad Goodarzi,Seturam B Katti,Yenamandra S Prabhakar. (2011-02-03) Consensus features of CP-MLR and GA in modeling HIV-1 RT inhibitory activity of 4-benzyl/benzoylpyridin-2-one analogues.. Journal of enzyme inhibition and medicinal chemistry, 26 ((5)): (696-705). [PMID:21284408] |
7. Philipp Ottiger,Samuel Leutwyler. (2011-06-18) Excitonic splittings in jet-cooled molecular dimers.. Chimia, 65 ((4)): (228-230). [PMID:21678767] |
8. Charalambos G Skoutelis,Dimitris Vlastos,Marianna C Kortsinidou,Ioannis T Theodoridis,Maria I Papadaki. (2011-10-08) Induction of micronuclei by 2-hydroxypyridine in water and elimination of solution genotoxicity by UVC (254 nm) photolysis.. Journal of hazardous materials, 197 (137-143). [PMID:21978588] |
9. Elango Kumarasamy,Josepha L Jesuraj,Joseph N Omlid,Angel Ugrinov,Jayaraman Sivaguru. (2011-10-11) Light-induced enantiospecific 4π ring closure of axially chiral 2-pyridones: enthalpic and entropic effects promoted by H-bonding.. Journal of the American Chemical Society, 133 ((43)): (17106-17109). [PMID:21981374] |
10. Mingwen Zhu,Ken-ichi Fujita,Ryohei Yamaguchi. (2011-11-15) Efficient synthesis of biazoles by aerobic oxidative homocoupling of azoles catalyzed by a copper(I)/2-pyridonate catalytic system.. Chemical communications (Cambridge, England), 47 ((48)): (12876-12878). [PMID:22076830] |
11. Istvan Horvath,Christoph F Weise,Emma K Andersson,Erik Chorell,Magnus Sellstedt,Christoffer Bengtsson,Anders Olofsson,Scott J Hultgren,Matthew Chapman,Magnus Wolf-Watz,Fredrik Almqvist,Pernilla Wittung-Stafshede. (2012-01-21) Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.. Journal of the American Chemical Society, 134 ((7)): (3439-3444). [PMID:22260746] |
12. Tista Sengupta,Krishnanka S Gayen,Palash Pandit,Dilip K Maiti. (2012-01-24) FeCl3⋅6H2O-catalyzed intermolecular-cascade cyclization of acetoacetanilide: aldehyde-tuned synthesis to valuable 2-pyridone analogues.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((7)): (1905-1909). [PMID:22266708] |
13. Haider Behbehani,Hamada Mohamed Ibrahim,Saad Makhseed,Mohamed H Elnagdi,Huda Mahmoud. (2012-04-03) 2-Aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]pyrimidine, quinoline and pyridin-2-one derivatives.. European journal of medicinal chemistry, 52 (51-65). [PMID:22464424] |
14. Shaoxia Lin,Ying Wei,Fushun Liang,Baozhong Zhao,Yanling Liu,Pengjun Liu. (2012-05-10) Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones.. Organic & biomolecular chemistry, 10 ((23)): (4571-4576). [PMID:22569769] |
15. Christian Wiegand,Eberhardt Herdtweck,Thorsten Bach. (2012-09-11) Enantioselectivity in visible light-induced, singlet oxygen [2+4] cycloaddition reactions (type II photooxygenations) of 2-pyridones.. Chemical communications (Cambridge, England), 48 ((82)): (10195-10197). [PMID:22962664] |
16. Felix Plasser,Giovanni Granucci,Jiri Pittner,Mario Barbatti,Maurizio Persico,Hans Lischka. (2012-12-20) Surface hopping dynamics using a locally diabatic formalism: charge transfer in the ethylene dimer cation and excited state dynamics in the 2-pyridone dimer.. The Journal of chemical physics, 137 ((22)): (22A514-22A514). [PMID:23249051] |
17. Ken-ichi Kusakabe,Yukio Tada,Yasuyoshi Iso,Masahiro Sakagami,Yasuhide Morioka,Nobuo Chomei,Satomi Shinonome,Keiko Kawamoto,Hideyuki Takenaka,Kiyoshi Yasui,Hiroshi Hamana,Kohji Hanasaki. (2013-02-12) Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.. Bioorganic & medicinal chemistry, 21 ((7)): (2045-2055). [PMID:23395112] |
18. Magdalena Hagn,Sue E Blackwell,Thamara Beyer,Verena Ebel,Dorit Fabricius,Stefanie Lindner,Stefan Stilgenbauer,Thomas Simmet,Constantine Tam,Paul Neeson,Joseph A Trapani,Hubert Schrezenmeier,George J Weiner,Bernd Jahrsdörfer. (2014-02-06) B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.. International immunology, 26 ((7)): (383-395). [PMID:24497611] |
19. Tiane Dai,Ying Wang,Aditi Nayak,Cynthia C Nast,Lan Quang,Janine LaPage,Ali Andalibi,Sharon G Adler. (2014-07-10) Janus kinase signaling activation mediates peritoneal inflammation and injury in vitro and in vivo in response to dialysate.. Kidney international, 86 ((6)): (1187-1196). [PMID:25007168] |
20. Michael Bordonaro,Eric Drago,Wafa Atamna,Darina L Lazarova. (2014-12-17) Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy.. PloS one, 9 ((12)): (e115068-e115068). [PMID:25500581] |
21. Léon A Tapondjou,Kristina J Siems,Stefan Böttger,Matthias F Melzig. (2016-01-12) Steroidal Saponins from the Mesocarp of the Fruits of Raphia farinifera (Arecaceae) and their Cytotoxic Activity.. Natural product communications, 10 ((11)): (1941-1944). [PMID:26749832] |
22. Henryk T Flakus,Aleksandra Tyl,Andrzej Maślankiewicz. (2011-01-21) Electron-induced phase transition in hydrogen-bonded solid-state 2-pyridone.. The journal of physical chemistry. A, 115 ((6)): (1027-1039). [PMID:21247179] |
23. Susan Blaser,Philipp Ottiger,Simon Lobsiger,Hans-Martin Frey,Samuel Leutwyler. (2011-05-25) Intermolecular clamping by hydrogen bonds: 2-pyridone⋅NH3.. Chemphyschem : a European journal of chemical physics and physical chemistry, 12 ((10)): (1841-1850). [PMID:21608099] |
24. Ruta Stanislauskiene,Renata Gasparaviciute,Justas Vaitekunas,Rita Meskiene,Rasa Rutkiene,Vida Casaite,Rolandas Meskys. (2011-11-22) Construction of Escherichia coli-Arthrobacter-Rhodococcus shuttle vectors based on a cryptic plasmid from Arthrobacter rhombi and investigation of their application for functional screening.. FEMS microbiology letters, 327 ((1)): (78-86). [PMID:22098420] |
25. Maria W Hirschbeck,Jochen Kuper,Hao Lu,Nina Liu,Carla Neckles,Sonam Shah,Steffen Wagner,Christoph A Sotriffer,Peter J Tonge,Caroline Kisker. (2012-01-17) Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.. Structure (London, England : 1993), 20 ((1)): (89-100). [PMID:22244758] |
26. Erik Chorell,Jerome S Pinkner,Christoffer Bengtsson,Thomas Sainte-Luce Banchelin,Sofie Edvinsson,Anna Linusson,Scott J Hultgren,Fredrik Almqvist. (2012-04-03) Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study.. Bioorganic & medicinal chemistry, 20 ((9)): (3128-3142). [PMID:22464688] |
27. Benjamin Voigt,Ulf Scheffler,Rainer Mahrwald. (2012-04-19) Stereoselective amine-catalyzed carbohydrate chain elongation.. Chemical communications (Cambridge, England), 48 ((43)): (5304-5306). [PMID:22510673] |
28. Mettu Ravinder,Budde Mahendar,Saidulu Mattapally,Kommi Venkata Hamsini,Thatikonda Narendar Reddy,Chilappa Rohit,Kolupula Srinivas,Sanjay Kumar Banerjee,Vaidya Jayathirtha Rao. (2012-08-18) Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): a target for heart failure and platelet aggregation.. Bioorganic & medicinal chemistry letters, 22 ((18)): (6010-6015). [PMID:22897945] |
29. Istvan Horvath,Magnus Sellstedt,Christoph Weise,Lina-Maria Nordvall,G Krishna Prasad,Anders Olofsson,Göran Larsson,Fredrik Almqvist,Pernilla Wittung-Stafshede. (2013-02-13) Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure.. Archives of biochemistry and biophysics, 532 ((2)): (84-90). [PMID:23399432] |
30. Kyung-Baeg Roh,Il-Hyun Kim,Young-Soo Kim,Myungjae Lee,Jung-A Lee,Eunsun Jung,Deokhoon Park. (2014-08-12) Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.. Molecules (Basel, Switzerland), 19 ((8)): (11883-11895). [PMID:25111027] |
31. Gordon P Meares,Yudong Liu,Rajani Rajbhandari,Hongwei Qin,Susan E Nozell,James A Mobley,John A Corbett,Etty N Benveniste. (2014-08-13) PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.. Molecular and cellular biology, 34 ((20)): (3911-3925). [PMID:25113558] |
32. Chryso Kanthou,Gabi U Dachs,Diane V Lefley,Andrew J Steele,Claudia Coralli-Foxon,Sheila Harris,Olga Greco,Sofia A Dos Santos,Constantino C Reyes-Aldasoro,William R English,Gillian M Tozer. (2014-08-15) Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics.. PloS one, 9 ((8)): (e104015-e104015). [PMID:25119572] |
33. Andreas H Wagner,Michael Conzelmann,Franziska Fitzer,Thomas Giese,Karsten Gülow,Christine S Falk,Oliver H Krämer,Sascha Dietrich,Markus Hecker,Thomas Luft. (2015-05-02) JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter.. Biochemical pharmacology, 96 ((1)): (52-64). [PMID:25931145] |
34. Ali A Abdul-Sater,Andrea Majoros,Courtney R Plumlee,Stuart Perry,Ai Di Gu,Carolyn Lee,Sujan Shresta,Thomas Decker,Christian Schindler. (2015-05-29) Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs.. Journal of immunology (Baltimore, Md. : 1950), 195 ((1)): (210-216). [PMID:26019270] |
35. Yaling Jiang,Yixin Liao,Hui He,Qiliang Xin,Zhaowei Tu,Shuangbo Kong,Tongtong Cui,Bingyan Wang,Song Quan,Bing Li,Shuang Zhang,Haibin Wang. (2015-09-04) FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization.. Scientific reports, 5 (13735-13735). [PMID:26334131] |
36. Zengchao Guo, Jiang Xiao, Weiwei Liu, Yihan Wang, Tengfei Liu, Hui Jiang, Xiaohui Liu, Xuemei Wang. (2023) Cationic porphyrin-based nanoparticles assisted with bio-assembly imaging-guided strategy for efficient inactivation of bacteria and promote wound healing. CHEMICAL ENGINEERING JOURNAL, 457 (141218). [PMID:] |
37. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] |