Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H286964-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $179.90 | |
H286964-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $249.90 | |
H286964-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $559.90 | |
H286964-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,009.90 | |
H286964-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,799.90 |
Selective GABABantagonist; more potent thanSaclofen
Synonyms | 2-OH-Saclofen | 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid | 2-Hydroxy-saclofen | (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid | 3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid |
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Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Selective antagonist at GABABreceptors. |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of GABA B1;Antagonist of GABA B receptor |
Product Description | 2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats. |
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IUPAC Name | 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid |
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INCHI | InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15) |
InChi Key | WBSMZVIMANOCNX-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl |
Isomeric SMILES | C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl |
PubChem CID | 1564 |
Molecular Weight | 265.71 |
Solubility | Solvent:water, Max Conc. mg/mL: None, Max Conc. mM: 5; Solvent:1eq. NaOH, Max Conc. mg/mL: None, Max Conc. mM: 100 |
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Pictogram(s) | GHS05 |
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Signal | Danger |
Hazard Statements | H314:Causes severe skin burns and eye damage |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |