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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Basic Description
| Synonyms | 2-oxobutanoic acid | 2-ketobutyric acid | 2-oxobutyric acid | 600-18-0 | alpha-ketobutyric acid | BUTANOIC ACID, 2-OXO- | 2-oxobutyrate | 3-Methylpyruvic acid | Ketobutyrate | Propionylformic acid | Butyric acid, 2-oxo- | 2-Ketobutanoic acid | Pyruvic acid, methyl- | Formic acid, |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | 2-Oxobutyric acid is mainly found in the hydrolysates of proteins, reportedly being formed by the degradation of threonine. |
Associated Targets(Human)
SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)
Associated Targets(non-human)
dapA Dihydrodipicolinate synthase (65 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Catharanthus roseus (29 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | 2-oxobutanoic acid |
|---|---|
| INCHI | InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7) |
| InChi Key | TYEYBOSBBBHJIV-UHFFFAOYSA-N |
| Canonical SMILES | CCC(=O)C(=O)O |
| Isomeric SMILES | CCC(=O)C(=O)O |
| WGK Germany | 3 |
| PubChem CID | 58 |
| Molecular Weight | 102.09 |
| Beilstein | 1700514 |
| Reaxy-Rn | 1700514 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Sensitivity | Hygroscopic, Heat sensitive |
|---|---|
| Flash Point(°F) | 179.6 °F |
| Flash Point(°C) | 81℃ |
| Boil Point(°C) | 84°C/20mmHg |
| Melt Point(°C) | 30-34°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 1700514 |
Related Documents
Citations of This Product
| 1. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan. (2023) Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 122 (110689). [PMID:36462602] [10.1016/j.pnpbp.2022.110689] |
| 2. Zhang Zhiwei, Liu Yang, Zhao Jing, Li Wenqiang, Hu Ruiwen, Li Xia, Li Aitao, Wang Yaping, Ma Lixin. (2021) Active-site engineering of ω-transaminase from Ochrobactrum anthropi for preparation of L-2-aminobutyric acid. BMC BIOTECHNOLOGY, 21 (1): (1-9). [PMID:34563172] [10.1186/s12896-021-00713-7] |
| 3. Wei Luo, Jiagui Hu, Jiapeng Lu, Huili Zhang, Xiaoping Wang, Yuantao Liu, Liqing Dong, Xiaobin Yu. (2021) One pot cascade synthesis of L-2-aminobutyric acid employing ω-transaminase from Paracoccus pantotrophus. Molecular Catalysis, 515 (111890). [PMID:] [10.1016/j.mcat.2021.111890] |
| 4. Liuzhu Wang, Shiqing Diao, Yangyang Sun, Shuiqin Jiang, Yan Liu, Hualei Wang, Dongzhi Wei. (2021) Rational engineering of Acinetobacter tandoii glutamate dehydrogenase for asymmetric synthesis of L-homoalanine through biocatalytic cascades. Catalysis Science & Technology, 11 (12): (4208-4215). [PMID:] [10.1039/D1CY00376C] |
| 5. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2020) Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates. Catalysis Science & Technology, 10 (10): (3376-3386). [PMID:] [10.1039/C9CY02576F] |
| 6. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2018) Rational Molecular Engineering of Glutamate Dehydrogenases for Enhancing Asymmetric Reductive Amination of Bulky α-Keto Acids. ADVANCED SYNTHESIS & CATALYSIS, 361 (4): (803-812). [PMID:] [10.1002/adsc.201801251] |
References
| 1. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan. (2023) Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 122 (110689). [PMID:36462602] [10.1016/j.pnpbp.2022.110689] |
| 2. Zhang Zhiwei, Liu Yang, Zhao Jing, Li Wenqiang, Hu Ruiwen, Li Xia, Li Aitao, Wang Yaping, Ma Lixin. (2021) Active-site engineering of ω-transaminase from Ochrobactrum anthropi for preparation of L-2-aminobutyric acid. BMC BIOTECHNOLOGY, 21 (1): (1-9). [PMID:34563172] [10.1186/s12896-021-00713-7] |
| 3. Wei Luo, Jiagui Hu, Jiapeng Lu, Huili Zhang, Xiaoping Wang, Yuantao Liu, Liqing Dong, Xiaobin Yu. (2021) One pot cascade synthesis of L-2-aminobutyric acid employing ω-transaminase from Paracoccus pantotrophus. Molecular Catalysis, 515 (111890). [PMID:] [10.1016/j.mcat.2021.111890] |
| 4. Liuzhu Wang, Shiqing Diao, Yangyang Sun, Shuiqin Jiang, Yan Liu, Hualei Wang, Dongzhi Wei. (2021) Rational engineering of Acinetobacter tandoii glutamate dehydrogenase for asymmetric synthesis of L-homoalanine through biocatalytic cascades. Catalysis Science & Technology, 11 (12): (4208-4215). [PMID:] [10.1039/D1CY00376C] |
| 5. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2020) Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates. Catalysis Science & Technology, 10 (10): (3376-3386). [PMID:] [10.1039/C9CY02576F] |
| 6. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2018) Rational Molecular Engineering of Glutamate Dehydrogenases for Enhancing Asymmetric Reductive Amination of Bulky α-Keto Acids. ADVANCED SYNTHESIS & CATALYSIS, 361 (4): (803-812). [PMID:] [10.1002/adsc.201801251] |