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M106467-5g

In stock

$14.90

M106467-25g

25g

In stock

$53.90

M106467-100g

100g

In stock

$157.90

Basic Description

Synonyms	2-Mercaptonicotinic acid \| 38521-46-9 \| 2-Mercaptopyridine-3-carboxylic acid \| 2-sulfanylpyridine-3-carboxylic acid \| 2-sulfanylidene-1H-pyridine-3-carboxylic acid \| 2-Mercapto-nicotinic acid \| 3-Pyridinecarboxylic acid, 1,2-dihydro-2-thioxo- \| 1,2-dihydro-2-thioxopyri
Specifications & Purity	≥99%
Shipped In	Normal
Product Description	2-Mercaptopyridine-3-carboxylic acid may be used for the synthesis of poly[[diaquabis([μ]2-4,4 ′-bipyridyl)iron(II)] bis{2-[(3-carboxypyridin-2-yl)disulfanyl]nicotinate}] and 2-(2-carboxyethylthio)nicotinic acid.

Associated Targets(Human)

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HDAC8 Tclin Histone deacetylase 8 (4516 Activities)

Discover Target: HDAC8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AOX1 Tchem Aldehyde oxidase (429 Activities)

Discover Target: AOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EYA2 Tbio Eyes absent homolog 2 (5884 Activities)

Discover Target: EYA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cat Catalase (15 Activities)

Discover Target: Cat

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488191038
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488191038
IUPAC Name	2-sulfanylidene-1H-pyridine-3-carboxylic acid
INCHI	InChI=1S/C6H5NO2S/c8-6(9)4-2-1-3-7-5(4)10/h1-3H,(H,7,10)(H,8,9)
InChi Key	WYKHFQKONWMWQM-UHFFFAOYSA-N
Canonical SMILES	C1=CNC(=S)C(=C1)C(=O)O
Isomeric SMILES	C1=CNC(=S)C(=C1)C(=O)O
WGK Germany	3
PubChem CID	673681
Molecular Weight	155.17
Beilstein	119029
Reaxy-Rn	119029

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2004037	Certificate of Analysis	May 09, 2024	M106467
B2317479	Certificate of Analysis	Jul 28, 2022	M106467
J2213587	Certificate of Analysis	Jul 28, 2022	M106467
J2213817	Certificate of Analysis	Jul 28, 2022	M106467

Chemical and Physical Properties

Melt Point(°C)	263-265°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	119029

References

1. A M Bode,J D Foster,R C Nordlie. (1993-03-01) Inhibition of glucose-6-phosphate phosphohydrolase by 3-mercaptopicolinate and two analogs is metabolically directive.. Biochemistry and cell biology = Biochimie et biologie cellulaire, 71 ((3-4)): (113-121). [PMID:8398068]
2. Marianna N Xanthopoulou,Sotiris K Hadjikakou,Nick Hadjiliadis,Markus Schürmann,Klaus Jurkschat,Adonis Michaelides,Stavroula Skoulika,Thomas Bakas,Jayne Binolis,Spyros Karkabounas,Konstantinos Charalabopoulos. (2003-07-31) Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2-mercaptobenzothiazole and 2-mercaptonicotinic acid.. Journal of inorganic biochemistry, 96 ((2-3)): (425-434). [PMID:12888279]
3. Hao Qian,ChunJiao Li,ZhiYong Lin,YingXue Zhang. (2009-09-29) Using thiophilic magnetic beads in purification of antibodies from human serum.. Colloids and surfaces. B, Biointerfaces, 75 ((1)): (342-348). [PMID:19783128]
4. Xiao-Juan Wang,Yun-Long Feng. (2010-01-01) 2-(Carboxy-methyl-sulfan-yl)pyridine-3-carboxylic acid monohydrate.. Acta crystallographica. Section E, Structure reports online, 66 ((Pt 6)): (o1298-o1298). [PMID:21579395]
5. Javed Iqbal,Gul Shahnaz,Sarah Dünnhaupt,Christiane Müller,Fabian Hintzen,Andreas Bernkop-Schnürch. (2011-11-29) Preactivated thiomers as mucoadhesive polymers for drug delivery.. Biomaterials, 33 ((5)): (1528-1535). [PMID:22118819]
6. Xueqing Wang,Javed Iqbal,Deni Rahmat,Andreas Bernkop-Schnürch. (2012-09-11) Preactivated thiomers: permeation enhancing properties.. International journal of pharmaceutics, 438 ((1-2)): (217-224). [PMID:22960503]
7. Sabine Hauptstein,Fabian Hintzen,Christiane Müller,Moritz Ohm,Andreas Bernkop-Schnürch. (2013-09-13) Development and in vitro evaluation of a buccal drug delivery system based on preactivated thiolated pectin.. Drug development and industrial pharmacy, 40 ((11)): (1530-1537). [PMID:24025071]
8. Sabine Hauptstein,Sonja Bonengel,Julia Rohrer,Andreas Bernkop-Schnürch. (2014-07-16) Preactivated thiolated poly(methacrylic acid-co-ethyl acrylate): synthesis and evaluation of mucoadhesive potential.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63 (132-139). [PMID:25019181]
9. Arshad Mahmood,Sonja Bonengel,Flavia Laffleur,Muhammad Ijaz,Gintare Leonaviciute,Andreas Bernkop-Schnürch. (2015-10-11) An in-vitro exploration of permeation enhancement by novel polysulfonate thiomers.. International journal of pharmaceutics, 496 ((2)): (304-313). [PMID:26453783]
10. Claudia Menzel,Sonja Bonengel,Irene Pereira de Sousa,Flavia Laffleur,Felix Prüfert,Andreas Bernkop-Schnürch. (2015-12-04) Preactivated thiolated nanoparticles: A novel mucoadhesive dosage form.. International journal of pharmaceutics, 497 ((1-2)): (123-128). [PMID:26631639]
11. Flavia Laffleur,Lukas Bacher,Stefan Vanicek,Claudia Menzel,Ijaz Muhammad. (2016-01-17) Next generation of buccadhesive excipient: Preactivated carboxymethyl cellulose.. International journal of pharmaceutics, 500 ((1-2)): (120-127). [PMID:26773600]
12. Nicolás Arisnabarreta,Gustavo D Ruano,Magalí Lingenfelder,E Martín Patrito,Fernando P Cometto. (2017-11-08) Comparative Study of the Adsorption of Thiols and Selenols on Au(111) and Au(100).. Langmuir : the ACS journal of surfaces and colloids, 33 ((48)): (13733-13739). [PMID:29110489]
13. Shentang Wang,Xiaohui Gao,Xinxin Hang,Xiaofei Zhu,Haitao Han,Xiaokun Li,Wuping Liao,Wei Chen. (2018-05-04) Calixarene-Based {Ni18} Coordination Wheel: Highly Efficient Electrocatalyst for the Glucose Oxidation and Template for the Homogenous Cluster Fabrication.. Journal of the American Chemical Society, 140 ((20)): (6271-6277). [PMID:29722973]
14. Aamir Jalil,Barbara Matuszczak,Nguyet-Minh Nguyen Le,Arshad Mahmood,Flavia Laffleur,Andreas Bernkop-Schnürch. (2018-07-27) Synthesis and Characterization of Thiolated PVP-Iodine Complexes: Key to Highly Mucoadhesive Antimicrobial Gels.. Molecular pharmaceutics, 15 ((8)): (3527-3534). [PMID:30047266]
15. Christina Leichner,Christian Steinbring,Randi Angela Baus,Daniel Baecker,Ronald Gust,Andreas Bernkop-Schnürch. (2018-09-27) Reactive keratin derivatives: A promising strategy for covalent binding to hair.. Journal of colloid and interface science, 534 (533-541). [PMID:30253354]
16. Sally L McArthur,Marie C Vendettuoli,Buddy D Ratner,David G Castner. (2005-05-07) Methods for generating protein molecular ions in ToF-SIMS.. Langmuir : the ACS journal of surfaces and colloids, 20 ((9)): (3704-3709). [PMID:15875403]
17. Hao Qian,Zhiyong Lin,Huaming Xu,MingQin Chen. (2009-02-28) The efficient and specific isolation of the antibodies from human serum by thiophilic paramagnetic polymer nanospheres.. Biotechnology progress, 25 ((2)): (376-383). [PMID:19248151]
18. Maurizio Casarin,Thomas Devic,Alessia Famengo,Daniel Forrer,Silvia Gross,Eugenio Tondello,Andrea Vittadini. (2010-04-02) Molecular, electronic, and crystal structures of self-assembled hydrothermally synthesized Zn(II)-mercaptonicotinate: a combined spectroscopic and theoretical approach.. Inorganic chemistry, 49 ((9)): (4099-4108). [PMID:20356058]
19. Ioannis I Verginadis,Spyridon Karkabounas,Yannis Simos,Evangelos Kontargiris,Sotiris K Hadjikakou,Anna Batistatou,Angelos Evangelou,Konstantinos Charalabopoulos. (2010-12-07) Anticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar rats.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 42 ((3)): (253-261). [PMID:21130873]
20. Sonja Bonengel,Sabine Haupstein,Glen Perera,Andreas Bernkop-Schnürch. (2014-06-25) Thiolated and S-protected hydrophobically modified cross-linked poly(acrylic acid)--a new generation of multifunctional polymers.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88 ((2)): (390-396). [PMID:24960111]
21. Alexandra Partenhauser,Kesinee Netsomboon,Irene Pereira de Sousa,Flavia Laffleur,Andreas Bernkop-Schnürch. (2015-11-28) Preactivated silicone oil as potential long-term vitreous replacement with nonemulsifying properties.. Journal of biomedical materials research. Part B, Applied biomaterials, 105 ((3)): (551-559). [PMID:26613571]
22. Mara Perrone,Antonio Lopalco,Angela Lopedota,Annalisa Cutrignelli,Valentino Laquintana,Justin Douglas,Massimo Franco,Elisa Liberati,Vincenzo Russo,Serena Tongiani,Nunzio Denora,Andreas Bernkop-Schnürch. (2017-06-15) Preactivated thiolated glycogen as mucoadhesive polymer for drug delivery.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 119 (161-169). [PMID:28610879]
23. Flavia Laffleur,Sonja Röttges. (2019-06-04) Buccal adhesive chitosan conjugate comprising pilocarpine for xerostomia.. International journal of biological macromolecules, 135 (1043-1051). [PMID:31158424]
24. Iram Shahzadi,Andrea Fürst,Zeynep Burcu Akkus-Dagdeviren,Shumaila Arshad,Markus Kurpiers,Barbara Matuszczak,Andreas Bernkop-Schnürch. (2020-06-04) Less Reactive Thiol Ligands: Key towards Highly Mucoadhesive Drug Delivery Systems.. Polymers, 12 ((6)): [PMID:32486313]

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2-Mercaptonicotinic acid - 99%, high purity , CAS No.38521-46-9

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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