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2-PMPA - 98% (HPLC), high purity , CAS No.173039-10-6

≥98%(HPLC)

CAS#: 173039-10-6
Formula: C₆H₁₁O₇P
Molecular Weight: 226.12
MDL number: MFCD00940167
PubChem CID: 10130754

Item Number

P167889

Grouped product items
SKU	Size	Availability	Price
P167889-5mg	5mg	In stock	$75.90
P167889-10mg	10mg	In stock	$118.90
P167889-25mg	25mg	In stock	$238.90
P167889-50mg	50mg	In stock	$347.90
P167889-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$565.90

Basic Description

Synonyms	HMS3412K10 \| HMS3676K10 \| HY-100788 \| 2-PMPA, >=98% (HPLC) \| PMPA(NAALADaseinhibitor) \| Pentanedioic acid, 2-(phosphonomethyl)- \| UNII-XH88WJG9LJ \| AKOS016004257 \| HMS3749M13 \| HMS3267D10 \| (R,S)-2-phosphonomethylpentanedioic acid \| YGA03910 \| SCHEMBL3831
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	2-PMPA 是一种有效的（IC50 ~ 1 nM）选择性谷氨酸羧肽酶 II（GCPII）抑制剂，也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I（NAALADase I）、NAAG 肽酶或前列腺素-特异性膜抗原（PSMA）。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍，并防止梭曼诱导的神经病理学。 2-PMPA 是谷氨酸羧肽酶 II（GCPII）的有效选择性抑制剂。 2-（膦酰基甲基）戊二酸（2-PMPA）阻断由低单位剂量的可卡因维持的静
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

FOLH1 Tclin Glutamate carboxypeptidase 2 (15 Activities)

Discover Target: FOLH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NAALAD2 Tchem N-acetylated-alpha-linked acidic dipeptidase 2 (1 Activities)

Discover Target: NAALAD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FOLH1 Tclin Glutamate carboxypeptidase II (711 Activities)

Discover Target: FOLH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NAALAD2 Tchem NAALADase II (20 Activities)

Discover Target: NAALAD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-(phosphonomethyl)pentanedioic acid
INCHI	InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
InChi Key	ISEYJGQFXSTPMQ-UHFFFAOYSA-N
Canonical SMILES	C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
Isomeric SMILES	C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
RTECS	SA0454800
PubChem CID	10130754
Molecular Weight	226.12

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
C2212126	Certificate of Analysis	Feb 21, 2022	P167889
C2212127	Certificate of Analysis	Feb 21, 2022	P167889
C2212142	Certificate of Analysis	Feb 21, 2022	P167889
C2214226	Certificate of Analysis	Feb 21, 2022	P167889
C2214227	Certificate of Analysis	Feb 21, 2022	P167889

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P264:Wash hands [and …] thoroughly after handling. P337+P313:IF eye irritation persists: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
RTECS	SA0454800

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2-PMPA - 98% (HPLC), high purity , CAS No.173039-10-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

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