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2-Pyrazinecarboxylic acid - 98%, high purity , CAS No.98-97-5

3 Citations

≥98%

CAS#: 98-97-5
Formula: C₅H₄N₂O₂
Molecular Weight: 124.1
Beilstein Registry Number: 112305
EC Number: 202-718-1
MDL number: MFCD00006130
PubChem CID: 1047
PubChem SID: 488179593

Item Number

P106883

Grouped product items
SKU	Size	Availability	Price
P106883-5g	5g	In stock	$10.90
P106883-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$16.90
P106883-25g	25g	In stock	$31.90
P106883-100g	100g	In stock	$112.90
P106883-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$304.90

View related series

carboxylic acid Six-Membered Heterocyclic Compounds

Basic Description

Synonyms	BP-30070 \| EN300-19900 \| 2WB23298SP \| 2-pyrazinic acid \| pyrazinoicacid \| VGL \| PYRAZINE CARBOXYLIC ACID \| MLS000069596 \| Pyrazinic acid \| CHEBI:71311 \| HMS3371F05 \| Pyrazine-2-carboxylic acid \| 2-Carboxypyrazine \| HMS2234J12 \| pyrazine 2-carboxylic acid
Specifications & Purity	≥98%
Shipped In	Normal

Associated Targets(Human)

NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

Discover Target: SMAD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

Discover Target: RAPGEF3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)

Discover Target: Hcar2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium avium (4587 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium kansasii (6484 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Mycobacterium tuberculosis variant bovis (1746 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)

Discover Target: clpP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488179593
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179593
IUPAC Name	pyrazine-2-carboxylic acid
INCHI	InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
InChi Key	NIPZZXUFJPQHNH-UHFFFAOYSA-N
Canonical SMILES	C1=CN=C(C=N1)C(=O)O
Isomeric SMILES	C1=CN=C(C=N1)C(=O)O
WGK Germany	3
PubChem CID	1047
Molecular Weight	124.1
Beilstein	112305
Reaxy-Rn	112305

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
C2110193	Certificate of Analysis	Dec 10, 2024	P106883
C2110194	Certificate of Analysis	Dec 10, 2024	P106883
C2110195	Certificate of Analysis	Dec 10, 2024	P106883
B2317098	Certificate of Analysis	Mar 01, 2023	P106883
D2324717	Certificate of Analysis	Dec 14, 2021	P106883
J2417288	Certificate of Analysis	Dec 14, 2021	P106883

Chemical and Physical Properties

Solubility	Solubility in hot Water：almost transparency
Melt Point(°C)	222-225°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	112305
Merck Index	8970

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hu Lei, Liu Su, Song Jie, Jiang Yetao, He Aiyong, Xu Jiaxing. (2020) Zirconium-Containing Organic–Inorganic Nanohybrid as a Highly Efficient Catalyst for the Selective Synthesis of Biomass-Derived 2,5-Dihydroxymethylfuran in Isopropanol. Waste and Biomass Valorization, 11 (7): (3485-3499). [PMID:] [10.1007/s12649-019-00703-z]
2. Xia Xu, Xiangxiang Qin, Ling Wang, Xiaofang Wang, Jing Lu, Xia Qiu, Yinggui Zhu. (2019) Lanthanide terbium complex: synthesis, electrochemiluminescence (ECL) performance, and sensing application. ANALYST, 144 (7): (2359-2366). [PMID:30793728] [10.1039/C9AN00137A]
3. Lei Hu, Ning Li, Xiaoli Dai, Yuqi Guo, Yetao Jiang, Aiyong He, Jiaxing Xu. (2019) Highly efficient production of 2,5-dihydroxymethylfuran from biomass-derived 5-hydroxymethylfurfural over an amorphous and mesoporous zirconium phosphonate catalyst. Journal of Energy Chemistry, 37 (82). [PMID:] [10.1016/j.jechem.2018.12.001]

References

1. Groll M, Berkers CR, Ploegh HL, Ovaa H. (2006) Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.. Structure, 14 (3): (451-6). [PMID:16531229] [10.1021/op500134e]
2. Mary Margaret Wade,Ying Zhang. (2004-07-24) Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis.. Journal of medical microbiology, 53 ((Pt 8)): (769-773). [PMID:15272064]
3. Takashi Iwanaga,Masanobu Sato,Tomoji Maeda,Toshio Ogihara,Ikumi Tamai. (2006-10-18) Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.. The Journal of pharmacology and experimental therapeutics, 320 ((1)): (211-217). [PMID:17043154]
4. Oren Zimhony,Catherine Vilchèze,Masayoshi Arai,John T Welch,William R Jacobs. (2006-11-15) Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.. Antimicrobial agents and chemotherapy, 51 ((2)): (752-754). [PMID:17101678]
5. Silvana C Ngo,Oren Zimhony,Woo Jin Chung,Halimah Sayahi,William R Jacobs,John T Welch. (2007-05-09) Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.. Antimicrobial agents and chemotherapy, 51 ((7)): (2430-2435). [PMID:17485499]
6. Bruce A Ellsworth,Ying Wang,Yeheng Zhu,Annapurna Pendri,Samuel W Gerritz,Chongqing Sun,Kenneth E Carlson,Liya Kang,Rose A Baska,Yifan Yang,Qi Huang,Neil T Burford,Mary Jane Cullen,Susan Johnghar,Kamelia Behnia,Mary Ann Pelleymounter,William N Washburn,William R Ewing. (2007-05-22) Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.. Bioorganic & medicinal chemistry letters, 17 ((14)): (3978-3982). [PMID:17513109]
7. Tawfik Gharbaoui,Philip J Skinner,Young-Jun Shin,Claudia Averbuj,Jae-Kyu Jung,Benjamin R Johnson,Tracy Duong,Marc Decaire,Jane Uy,Martin C Cherrier,Peter J Webb,Susan Y Tamura,Ning Zou,Nathalie Rodriguez,P Douglas Boatman,Carleton R Sage,Andrew Lindstrom,Jerry Xu,Thomas O Schrader,Brian M Smith,Ruoping Chen,Jeremy G Richman,Daniel T Connolly,Steven L Colletti,James R Tata,Graeme Semple. (2007-06-26) Agonist lead identification for the high affinity niacin receptor GPR109a.. Bioorganic & medicinal chemistry letters, 17 ((17)): (4914-4919). [PMID:17588745]
8. Stefania Tanase,Patricia Marques-Gallego,Wesley R Browne,Ronald Hage,Elisabeth Bouwman,Ben L Feringa,Jan Reedijk. (2008-04-03) Mechanistic implications of the active species involved in the oxidation of hydrocarbons by iron complexes of pyrazine-2-carboxylic acid.. Dalton transactions (Cambridge, England : 2003), ((15)(15)): (2026-2033). [PMID:18382780]
9. Keisuke Kagami,Kenji Onda,Kitaro Oka,Toshihiko Hirano. (2008-07-01) Suppression of blood lipid concentrations by volatile Maillard reaction products.. Nutrition (Burbank, Los Angeles County, Calif.), 24 ((11-12)): (1159-1166). [PMID:18586457]
10. Wolfgang Holzer,Gernot A Eller,Barbara Datterl,Daniela Habicht. (2009-04-30) Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations.. Magnetic resonance in chemistry : MRC, 47 ((7)): (617-624). [PMID:19402051]
11. Marta Filipa Simões,Emília Valente,M José Rodríguez Gómez,Elsa Anes,Luís Constantino. (2009-06-06) Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 37 ((3-4)): (257-263). [PMID:19491013]
12. João P S Fernandes,Kerly F M Pasqualoto,Veni M A Felli,Elizabeth I Ferreira,Carlos A Brandt. (2010-01-26) QSAR modeling of a set of pyrazinoate esters as antituberculosis prodrugs.. Archiv der Pharmazie, 343 ((2)): (91-97). [PMID:20099263]
13. Anthony D Baughn,Jiaoyu Deng,Catherine Vilchèze,Angelica Riestra,John T Welch,William R Jacobs,Oren Zimhony. (2010-09-30) Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.. Antimicrobial agents and chemotherapy, 54 ((12)): (5323-5328). [PMID:20876380]
14. Ping Lu,Anna C Haagsma,Hoang Pham,Janneke J Maaskant,Selena Mol,Holger Lill,Dirk Bald. (2011-08-31) Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.. Antimicrobial agents and chemotherapy, 55 ((11)): (5354-5357). [PMID:21876062]
15. Stewart T Cole. (2011-09-17) Microbiology. Pyrazinamide--old TB drug finds new target.. Science (New York, N.Y.), 333 ((6049)): (1583-1584). [PMID:21921185]
16. Martin Dolezal,Diana Kesetovic,Jan Zitko. (2011-11-15) Antimycobacterial evaluation of pyrazinoic acid reversible derivatives.. Current pharmaceutical design, 17 ((32)): (3506-3514). [PMID:22074423]
17. Mirko Zimic,Sebastian Loli,Robert H Gilman,Andrés Gutierrez,Patricia Fuentes,Milagros Cotrina,Daniela Kirwan,Patricia Sheen. (2012-03-01) A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis.. Microbial drug resistance (Larchmont, N.Y.), 18 ((4)): (372-375). [PMID:22372927]
18. Hyun Kim,Keigo Shibayama,Emiko Rimbara,Shigetarou Mori. (2014-06-21) Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.. PloS one, 9 ((6)): (e100062-e100062). [PMID:24949952]
19. W Ebeid,M Salim,E Elkady,A Elzahr,R El-Bagary,G Patonay. (2015-07-21) Simultaneous determination of valsartan, amlodipine besylate and hydrochlorothiazide using capillary zone electrophoresis (CZE).. Die Pharmazie, 70 ((6)): (368-373). [PMID:26189296]
20. Beatriz E Bolívar,John T Welch. (2017-02-22) Studies of the Binding of Modest Modulators of the Human Enzyme, Sirtuin\u20056, by STD NMR.. Chembiochem : a European journal of chemical biology, 18 ((10)): (931-940). [PMID:28222243]
21. Shirou Itagaki,Soji Shimamoto,Mitsuru Sugawara,Michiya Kobayashi,Katsumi Miyazaki,Takeshi Hirano,Ken Iseki. (2005-08-09) Phenolsulfonphthalein transport by potential-sensitive urate transport system.. European journal of pharmacology, 518 ((2-3)): (83-89). [PMID:16083873]
22. Rustam Z Khaliullin,Alexis T Bell,Martin Head-Gordon. (2006-07-21) A density functional theory study of the mechanism of free radical generation in the system vanadate/PCA/H2O2.. The journal of physical chemistry. B, 109 ((38)): (17984-17992). [PMID:16853308]
23. Jhy-Wen Wu,Tung-Hu Tsai. (2007-06-02) Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats.. Drug metabolism and disposition: the biological fate of chemicals, 35 ((9)): (1603-1610). [PMID:17540707]
24. Y Sheeena Mary,Hema Tresa Varghese,C Yohannan Panicker,Martin Dolezal. (2008-03-21) Vibrational spectroscopic studies and ab initio calculations of a substituted amide of pyrazine-2-carboxylic acid--C12H10ClN3O.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71 ((2)): (725-730). [PMID:18353710]
25. Michael J Munchhof,Amy S Antipas,Laura C Blumberg,William H Brissette,Matthew F Brown,Jeffrey M Casavant,Jonathan L Doty,James Driscoll,Thomas M Harris,Lilli A Wolf-Gouveia,Christopher S Jones,Qifang Li,Robert G Linde,Paul D Lira,Anthony Marfat,Eric McElroy,Mark Mitton-Fry,Sandra P McCurdy,Lawrence A Reiter,Sharon L Ripp,Andrei Shavnya,Lisa M Thomasco,Kristen A Trevena. (2009-02-03) The identification of orally bioavailable thrombopoietin agonists.. Bioorganic & medicinal chemistry letters, 19 ((5)): (1428-1430). [PMID:19186055]
26. Iwao Akashi,Keisuke Kagami,Toshihiko Hirano,Kitaro Oka. (2009-03-21) Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.. The Journal of pharmacy and pharmacology, 61 ((4)): (473-478). [PMID:19298694]
27. Mohamed Abdel-Aziz,Hamdy M Abdel-Rahman. (2010-05-22) Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.. European journal of medicinal chemistry, 45 ((8)): (3384-3388). [PMID:20488590]
28. Masanobu Sato,Tomohiko Wakayama,Hideaki Mamada,Yoshiyuki Shirasaka,Takeo Nakanishi,Ikumi Tamai. (2010-11-16) Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.. Biochimica et biophysica acta, 1808 ((6)): (1441-1447). [PMID:21074513]
29. Halimah Sayahi,Oren Zimhony,William R Jacobs,Alexander Shekhtman,John T Welch. (2011-07-22) Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I.. Bioorganic & medicinal chemistry letters, 21 ((16)): (4804-4807). [PMID:21775138]
30. Mirko Zimic,Patricia Fuentes,Robert H Gilman,Andrés H Gutiérrez,Daniela Kirwan,Patricia Sheen. (2011-10-19) Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.. Tuberculosis (Edinburgh, Scotland), 92 ((1)): (84-91). [PMID:22004792]
31. H J Kim,H K Kwak,J Lee,Y J Yun,J S Lee,M S Lee,S Y Min,S K Park,H S Kang,Y H Maeng,S Y Kim,S Y Kim,Y H Kook,Y R Kim,K H Lee. (2012-01-13) Patterns of pncA mutations in drug-resistant Mycobacterium tuberculosis isolated from patients in South Korea.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 16 ((1)): (98-103). [PMID:22236853]
32. Hu Lei, Liu Su, Song Jie, Jiang Yetao, He Aiyong, Xu Jiaxing. (2020) Zirconium-Containing Organic–Inorganic Nanohybrid as a Highly Efficient Catalyst for the Selective Synthesis of Biomass-Derived 2,5-Dihydroxymethylfuran in Isopropanol. Waste and Biomass Valorization, 11 (7): (3485-3499). [PMID:] [10.1007/s12649-019-00703-z]
33. Xia Xu, Xiangxiang Qin, Ling Wang, Xiaofang Wang, Jing Lu, Xia Qiu, Yinggui Zhu. (2019) Lanthanide terbium complex: synthesis, electrochemiluminescence (ECL) performance, and sensing application. ANALYST, 144 (7): (2359-2366). [PMID:30793728] [10.1039/C9AN00137A]
34. Lei Hu, Ning Li, Xiaoli Dai, Yuqi Guo, Yetao Jiang, Aiyong He, Jiaxing Xu. (2019) Highly efficient production of 2,5-dihydroxymethylfuran from biomass-derived 5-hydroxymethylfurfural over an amorphous and mesoporous zirconium phosphonate catalyst. Journal of Energy Chemistry, 37 (82). [PMID:] [10.1016/j.jechem.2018.12.001]

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2-Pyrazinecarboxylic acid - 98%, high purity , CAS No.98-97-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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