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T122399-25g

25g

Available within 8-12 weeks(?)

$9.90

T122399-100g

100g

In stock

$29.90

T122399-500g

500g

Available within 4-8 weeks(?)

$95.90

Basic Description

Synonyms	2-Mercaptothiazoline \| 96-53-7 \| 2-Thiazolidinethione \| 1,3-Thiazolidine-2-thione \| 2-Thiazoline-2-thiol \| Thiazolidine-2-thione \| 2-Mercapto-2-thiazoline \| Metabasal \| Thyroidan \| 2-Thiothiazolidone \| 4,5-dihydrothiazole-2-thiol \| Mercaptothiazoline \| Sancelent 2MT \| 2-Thiazolide
Specifications & Purity	≥98%
Shipped In	Normal
Product Description	Tool for highly selective chiral syntheses of penam- and carbapenam-type β-lactam antibiotics.

Associated Targets(Human)

PRKAA2 Tchem AMP-activated protein kinase, alpha-2 subunit (1328 Activities)

Discover Target: PRKAA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1,3-thiazolidine-2-thione
INCHI	InChI=1S/C3H5NS2/c5-3-4-1-2-6-3/h1-2H2,(H,4,5)
InChi Key	WGJCBBASTRWVJL-UHFFFAOYSA-N
Canonical SMILES	C1CSC(=S)N1
Isomeric SMILES	C1CSC(=S)N1
WGK Germany	3
RTECS	XJ6122000
PubChem CID	2723699
UN Number	2811
Packing Group	III
Molecular Weight	119.21
Beilstein	106332
Reaxy-Rn	106332

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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4 results found

Lot Number	Certificate Type	Date	Item
C2205557	Certificate of Analysis	Feb 15, 2022	T122399
C2205582	Certificate of Analysis	Feb 15, 2022	T122399
C2205589	Certificate of Analysis	Feb 15, 2022	T122399
F2405118	Certificate of Analysis	Feb 15, 2022	T122399

Chemical and Physical Properties

Solubility	Soluble in chloroform, methanol. Slightly soluble in water.
Melt Point(°C)	104.0 - 107.0℃

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RTECS	XJ6122000
Reaxy-Rn	106332
Class	6.1

References

1. J C Thomes,F Comby,J F Lagorce,J Buxeraud,C Raby. (1992-03-01) Sites of action of 2-thiazoline-2-thiol on biogenesis of thyroid hormones.. Japanese journal of pharmacology, 58 ((3)): (201-207). [PMID:1380999]
2. R B Greenwald,A Pendri,A Martinez,C Gilbert,P Bradley. (1996-11-01) PEG thiazolidine-2-thione, a novel reagent for facile protein modification: conjugation of bovine hemoglobin.. Bioconjugate chemistry, 7 ((6)): (638-641). [PMID:8950482]
3. M L Beyssen,J F Lagorce,D Cledat,J Buxeraud. (1999-08-24) Influence of dietary iodine on drug-induced hypothyrodism in the rat.. The Journal of pharmacy and pharmacology, 51 ((6)): (745-750). [PMID:10454054]
4. M T Crimmins, K Chaudhary,. (2001-02-07) Titanium enolates of thiazolidinethione chiral auxiliaries: versatile tools for asymmetric aldol additions.. Organic letters, 2 ((6)): ( 775-777 ). [PMID:10754681]
5. M Beyssen,J Lagorce,D Clédat,A Jambut,J Buxeraud. (2000-07-15) Antithyroid action of tamoxifen in the rat: in vivo and in vitro studies.. Pharmacology, 61 ((1)): (22-30). [PMID:10895077]
6. Taro Hase,Rikio Yoshimura,Makoto Mitsuhashi,Yoshihiro Segawa,Yutaka Kawahito,Seiji Wada,Tatsuya Nakatani,Hajime Sano. (2002-09-28) Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists.. Urology, 60 ((3)): (542-547). [PMID:12350514]
7. Y H Chen,C Y Chang,C C Chen,C Y Chiu,Y H Yu,P C Chiang,Y Ku,J N Chen,C F Chang. (2004-05-04) Decomposition of 2-mercaptothiazoline in aqueous solution by ozonation.. Chemosphere, 56 ((2)): (133-140). [PMID:15120559]
8. Vladimír Subr,Cestmír Konák,Richard Laga,Karel Ulbrich. (2006-01-10) Coating of DNA/poly(L-lysine) complexes by covalent attachment of poly[N-(2-hydroxypropyl)methacrylamide].. Biomacromolecules, 7 ((1)): (122-130). [PMID:16398506]
9. K Ulbrich,R Laga,V Subr. (2007-08-28) Reactive polymers for modification of biologically active molecules and gene delivery vectors.. Journal of controlled release : official journal of the Controlled Release Society, 116 ((2)): (e3-e5). [PMID:17718954]
10. Yoshinori Kadoma,Wakako Kumada,Yuhta Asai,Yoshiaki Sugita,Ichiro Yokoe,Seiichiro Fujisawa. (2007-10-26) Radical-scavenging activity of the reaction products of isoeugenol with thiol, thiophenol, mercaptothiazoline or mercaptomethylimidazole using the induction period method.. Molecules (Basel, Switzerland), 12 ((8)): (1836-1844). [PMID:17960091]
11. Usama M Rabie,Moustafa H M Abou-El-Wafa,Heba Nassar. (2010-12-15) In vitro simulation of the chemical scenario of the action of an anti-thyroid drug: charge transfer interaction of thiazolidine-2-thione with iodine.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 78 ((1)): (512-517). [PMID:21146452]
12. Yan Zhou,Jiyuan Yang,Jindřich Kopeček. (2011-12-06) Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells.. Biomaterials, 33 ((6)): (1863-1872). [PMID:22138033]
13. Homan Kang,Sinyoung Jeong,Yul Koh,Myeong Geun Cha,Jin-Kyoung Yang,San Kyeong,Jaehi Kim,Seon-Yeong Kwak,Hye-Jin Chang,Hyunmi Lee,Cheolhwan Jeong,Jong-Ho Kim,Bong-Hyun Jun,Yong-Kweon Kim,Dae Hong Jeong,Yoon-Sik Lee. (2015-05-29) Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis.. Scientific reports, 5 (10144-10144). [PMID:26017924]
14. Petra Votavova,Jakub Tomala,Vladimir Subr,Jiri Strohalm,Karel Ulbrich,Blanka Rihova,Marek Kovar. (2015-10-22) Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy.. Journal of biomedical nanotechnology, 11 ((9)): (1662-1673). [PMID:26485935]
15. P Bojarová,M R Tavares,D Laaf,L Bumba,L Petrásková,R Konefał,M Bláhová,H Pelantová,L Elling,T Etrych,P Chytil,V Křen. (2018-09-22) Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3.. Journal of nanobiotechnology, 16 ((1)): (73-73). [PMID:30236114]
16. Jing Wang,Huihui Jiang,Hai-Bo Liu,Lebao Liang,Junrong Tao. (2019-11-14) Pyrene-imidazole conjugate as a fluorescent sensor for the sequential detection of iron(III) and histidine in aqueous solution.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 228 (117725-117725). [PMID:31718975]
17. Robert Pola,Eliška Böhmová,Marcela Filipová,Michal Pechar,Jan Pankrác,David Větvička,Tomáš Olejár,Martina Kabešová,Pavla Poučková,Luděk Šefc,Michal Zábrodský,Olga Janoušková,Jan Bouček,Tomáš Etrych. (2020-01-08) Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors.. Pharmaceutics, 12 ((1)): [PMID:31906300]
18. Eliška Böhmová,Robert Pola,Michal Pechar,Jozef Parnica,Daniela Machová,Olga Janoušková,Tomáš Etrych. (2020-01-16) Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length.. Pharmaceutics, 12 ((1)): [PMID:31936737]
19. R van Doorn,L P Delbressine,C M Leijdekkers,P G Vertin,P T Henderson. (1981-03-01) Identification and determination of 2-thiothiazolidine-4-carboxylic acid in urine of workers exposed to carbon disulfide.. Archives of toxicology, 47 ((1)): (51-58). [PMID:7283740]
20. D Atzei,D De Filippo,A Rossi,M Porcelli. (2001-05-26) X-ray photoelectron spectra of Pd(II) and Pt(II) complexes with 1,3-thiazolidine-2-thione. A quantum mechanics study on the free ligand.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 57A ((5)): (1073-1083). [PMID:11374567]
21. Henryk T Flakus,Artur Miros,Peter G Jones. (2002-01-26) Polarization IR spectra of model crystals containing cyclic N-H...S bonded dimers: 2-mercaptothiazoline and 2-mercapto-1-methylimidazole.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 58 ((2)): (225-237). [PMID:11808728]
22. Newton L Dias Filho,Devaney R do Carmo,Fergus Gessner,André H Rosa. (2005-12-02) Preparation of a clay-modified carbon paste electrode based on 2-thiazoline-2-thiol-hexadecylammonium sorption for the sensitive determination of mercury.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 21 ((11)): (1309-1316). [PMID:16317899]
23. Cestmír Konák,Vladimír Subr,Libor Kostka,Petr Stepánek,Karel Ulbrich,Helmut Schlaad. (2008-06-12) Coating of vesicles with hydrophilic reactive polymers.. Langmuir : the ACS journal of surfaces and colloids, 24 ((14)): (7092-7098). [PMID:18543996]
24. Lei Tao,Jingquan Liu,Jiangtao Xu,Thomas P Davis. (2009-08-14) Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: the use of novel thiazolidine-2-thione coupling chemistry.. Organic & biomolecular chemistry, 7 ((17)): (3481-3485). [PMID:19675903]
25. Richard Laga,Cestmír Konák,Vladimír Subr,Karel Ulbrich,Nisaraporn Suthiwangcharoen,Zhongwei Niu,Qian Wang. (2010-06-12) Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers.. Journal of biomaterials science. Polymer edition, 21 ((12)): (1669-1685). [PMID:20537248]
26. Denis L Guerra,Adriano C Batista,Rúbia R Viana,Claudio Airoldi. (2010-08-03) Adsorption of methylene blue on raw and MTZ/imogolite hybrid surfaces: effect of concentration and calorimetric investigation.. Journal of hazardous materials, 183 ((1-3)): (81-86). [PMID:20674169]
27. Usama M Rabie,Moustafa H M Abou-El-Wafa,Heba Nassar. (2011-12-02) Interaction of thiazolidine-2-thione with 2,3,5,6-tetrabromo-1,4-benzoquinone: a set of sequential interactions involving redox and substitution reactions after an initial charge transfer complexation.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 86 (252-255). [PMID:22130556]
28. Arash Nanbakhsh,Cécile Pochon,Aude Mallavialle,Sophie Amsellem,Jean Henri Bourhis,Salem Chouaib. (2014-03-29) c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis.. Blood, 123 ((23)): (3585-3595). [PMID:24677544]
29. Yahia N Mabkhot,H Algarni,Abdulrhman Alsayari,Abdullatif Bin Muhsinah,Nabila A Kheder,Zainab M Almarhoon,Faiz A Al-Aizari. (2019-05-01) Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives.. Molecules (Basel, Switzerland), 24 ((9)): [PMID:31035531]

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2-Thiazoline-2-thiol - 98%, high purity , CAS No.96-53-7