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(2R)-2-[5-[6-amino-5-[(1R)-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol , CAS No.R609456, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of FER tyrosine kinase;Inhibitor of FES proto-oncogene; tyrosine kinase;Inhibitor of leukocyte receptor tyrosine kinase;Inhibitor of mitogen-activa

Moligand™

PubChem CID: 72710568

Item Number

R609456

Grouped product items
SKU	Size	Availability	Price	Qty
R609456-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$710.90
R609456-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,300.90

View related series

ALK receptor tyrosine kinase Inhibitor c-ros oncogene 1，receptor tyrosine kinase Inhibitor FER tyrosine kinase Inhibitor FES proto-oncogene，tyrosine kinase Inhibitor leukocyte receptor tyrosine kinase Inhibitor mitogen-activated protein kinase kinase kinase 9 Inhibitor neurotrophic receptor tyrosine kinase 2 Inhibitor

Basic Description

Synonyms	1549629-82-4\|PF-06439015\|CHEMBL3128069\|76PND635L1\|compound 8e [PMID: 24432909]\|(2R)-2-(5-(6-Amino-5-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-3-pyridinyl)-4-methyl-2-thiazolyl)-1,2-propanediol\|1,2-Propanediol, 2-(5-(6-amino-5-((1R)-1-(5-fl
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ALK receptor tyrosine kinase;Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of FER tyrosine kinase;Inhibitor of FES proto-oncogene; tyrosine kinase;Inhibitor of leukocyte receptor tyrosine kinase;Inhibitor of mitogen-activa

Associated Targets

PTK2 Tclin Focal adhesion kinase 1 1 Activities

Discover Target: PTK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROS1 Tclin Proto-oncogene tyrosine-protein kinase ROS 2 Activities

Discover Target: ROS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FER Tclin Tyrosine-protein kinase Fer 2 Activities

Discover Target: FER

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FES Tclin Tyrosine-protein kinase Fes/Fps 2 Activities

Discover Target: FES

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTK2B Tclin Protein-tyrosine kinase 2-beta 1 Activities

Discover Target: PTK2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LTK Tclin Leukocyte tyrosine kinase receptor 2 Activities

Discover Target: LTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK2 Tclin Activated CDC42 kinase 1 1 Activities

Discover Target: TNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALK Tclin ALK tyrosine kinase receptor 18 Activities

Discover Target: ALK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK2 Tclin BDNF/NT-3 growth factors receptor 2 Activities

Discover Target: NTRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 1 Activities

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK3 Tclin NT-3 growth factor receptor 1 Activities

Discover Target: NTRK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 1 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K9 Tchem Mitogen-activated protein kinase kinase kinase 9 1 Activities

Discover Target: MAP3K9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2R)-2-[5-[6-amino-5-[(1R)-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol
INCHI	InChI=1S/C22H23FN6O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25)/t13-,22-/m1/s1
InChi Key	DIXMBHMNEHPFCX-MCMMXHMISA-N
Canonical SMILES	OC[C@](c1nc(c(s1)c1cnc(c(c1)O[C@@H](c1cc(F)ccc1n1nccn1)C)N)C)(O)C
Isomeric SMILES	CC1=C(SC(=N1)[C@@](C)(CO)O)C2=CC(=C(N=C2)N)O[C@H](C)C3=C(C=CC(=C3)F)N4N=CC=N4
PubChem CID	72710568

PubChem CID

72710568

ChEMBL Ligand

CHEMBL3128069

References

1. Huang Q, Johnson TW, Bailey S, Brooun A, Bunker KD, Burke BJ, Collins MR, Cook AS, Cui JJ, Dack KN et al.. (2014) Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.. J Med Chem, 57 (4): (1170-87). [PMID:24432909]

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