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L-Arginine turnover
(2R)-2-amino-6-borono-2-(2-piperidin-1-ylethyl)hexanoic acid , CAS No.1345808-25-4, Inhibitor of Arginase I;Inhibitor of Arginase II

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(2R)-2-amino-6-borono-2-(2-piperidin-1-ylethyl)hexanoic acid , CAS No.1345808-25-4, Inhibitor of Arginase I;Inhibitor of Arginase II

Moligand™

≥98%

CAS#: 1345808-25-4
Formula: C₁₃H₂₇BN₂O₄
Molecular Weight: 286.18
PubChem CID: 66833213

Item Number

R609492

Grouped product items
SKU	Size	Availability	Price	Qty
R609492-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$312.90
R609492-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,408.90

View related series

Arginase I Inhibitor Arginase II Inhibitor

Basic Description

Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Arginase I;Inhibitor of Arginase II
Product Description	Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.

Associated Targets(Human)

ARG2 Tchem Arginase-2, mitochondrial (2 Activities)

Discover Target: ARG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARG1 Tchem Arginase-1 (3 Activities)

Discover Target: ARG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ARG1 Arginase-1 (70 Activities)

Discover Target: ARG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2R)-2-amino-6-borono-2-(2-piperidin-1-ylethyl)hexanoic acid
INCHI	InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
InChi Key	CHPILBYRQPOXMV-CYBMUJFWSA-N
Canonical SMILES	OB(CCCC[C@](C(=O)O)(CCN1CCCCC1)N)O
Isomeric SMILES	B(CCCC[C@@](CCN1CCCCC1)(C(=O)O)N)(O)O
PubChem CID	66833213
Molecular Weight	286.18

Database links

PubChem CID	66833213
ChEMBL Ligand	CHEMBL2326089
BindingDB Ligand	50427900
CAS Registry No.	1345808-25-4

Certificates

Certificate of Analysis(COA)

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Alternative Products

References

1. Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M et al.. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.. J Med Chem, 56 (6): (2568-80). [PMID:23472952] [10.1021/op500134e]

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