Grouped product items

SKU

Size

Availability

Price

Qty

C609445-5mg

5mg

Available within 8-12 weeks(?)

$1,334.90

C609445-25mg

25mg

Available within 8-12 weeks(?)

$2,000.90

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein tyrosine phosphatase non-receptor type 22;Inhibitor of RTP Type M

Associated Targets(Human)

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 (1 Activities)

Discover Target: PTPN11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN9 Tchem Tyrosine-protein phosphatase non-receptor type 9 (1 Activities)

Discover Target: PTPN9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (1 Activities)

Discover Target: PTPRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN12 Tchem Tyrosine-protein phosphatase non-receptor type 12 (1 Activities)

Discover Target: PTPN12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN13 Tchem Tyrosine-protein phosphatase non-receptor type 13 (1 Activities)

Discover Target: PTPN13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN6 Tchem Tyrosine-protein phosphatase non-receptor type 6 (1 Activities)

Discover Target: PTPN6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPRM Tchem Receptor-type tyrosine-protein phosphatase mu (1 Activities)

Discover Target: PTPRM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN22 Tchem Tyrosine-protein phosphatase non-receptor type 22 (1 Activities)

Discover Target: PTPN22

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1 Activities)

Discover Target: ACP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)

Discover Target: PTPN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN12 Tchem Protein-tyrosine phosphatase G1 (132 Activities)

Discover Target: PTPN12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DUSP3 Tchem Dual specificity protein phosphatase 3 (1161 Activities)

Discover Target: DUSP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRA Tchem Receptor-type tyrosine-protein phosphatase alpha (287 Activities)

Discover Target: PTPRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (330 Activities)

Discover Target: PTPRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)

Discover Target: PTPN6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN7 Tchem Protein-tyrosine phosphatase LC-PTP (886 Activities)

Discover Target: PTPN7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

Discover Target: PTPN11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN13 Tchem Protein-tyrosine phosphatase 1E (88 Activities)

Discover Target: PTPN13

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRC Tchem Leukocyte common antigen (2317 Activities)

Discover Target: PTPRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRF Tchem Receptor-type tyrosine-protein phosphatase F (LAR) (718 Activities)

Discover Target: PTPRF

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN22 Tchem Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (1215 Activities)

Discover Target: PTPN22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRE Tbio Receptor-type tyrosine-protein phosphatase epsilon (68 Activities)

Discover Target: PTPRE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRM Tchem Receptor-type tyrosine-protein phosphatase mu (41 Activities)

Discover Target: PTPRM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)

Discover Target: ACP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRG Tchem Receptor-type tyrosine-protein phosphatase gamma (63 Activities)

Discover Target: PTPRG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN9 Tchem Tyrosine-protein phosphatase non-receptor type 9 (97 Activities)

Discover Target: PTPN9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EPM2A Tbio Laforin (13 Activities)

Discover Target: EPM2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DUSP23 Tbio Dual specificity protein phosphatase 23 (16 Activities)

Discover Target: DUSP23

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DUSP15 Tbio Dual specificity protein phosphatase 15 (2 Activities)

Discover Target: DUSP15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPRS Tchem Receptor-type tyrosine-protein phosphatase S (105 Activities)

Discover Target: PTPRS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Dusp6 Dual specificity protein phosphatase 6 (459 Activities)

Discover Target: Dusp6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[2-(3-chlorophenyl)ethynyl]-6-hydroxy-2-[4-[2-oxo-2-(propylamino)ethoxy]phenyl]-1-benzofuran-5-carboxylic acid
INCHI	InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)
InChi Key	ZAKVHDWXAFAMTH-UHFFFAOYSA-N
Canonical SMILES	CCCNC(=O)COc1ccc(cc1)c1oc2c(c1C#Cc1cccc(c1)Cl)cc(c(c2)O)C(=O)O
Isomeric SMILES	CCCNC(=O)COC1=CC=C(C=C1)C2=C(C3=CC(=C(C=C3O2)O)C(=O)O)C#CC4=CC(=CC=C4)Cl
PubChem CID	71734765

Database links

PubChem CID	71734765
ChEMBL Ligand	CHEMBL2396718

Certificates

Certificate of Analysis(COA)

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References

1. Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.. Proc Natl Acad Sci USA, 104 (50): (19767-72). [PMID:18056643] [10.1021/op500134e]
2. Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F et al.. (2005) Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.. Nat Genet, 37 (12): (1317-9). [PMID:16273109] [10.1021/op500134e]
3. Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, Jeffery D, Mortara K, Sampang J, Williams SR et al.. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22.. J Biol Chem, 281 (16): (11002-10). [PMID:16461343] [10.1021/op500134e]
4. He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N et al.. (2013) A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.. J Med Chem, 56 (12): (4990-5008). [PMID:23713581] [10.1021/op500134e]

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3-[2-(3-chlorophenyl)ethynyl]-6-hydroxy-2-[4-[2-oxo-2-(propylamino)ethoxy]phenyl]-1-benzofuran-5-carboxylic acid , CAS No.C609445, Inhibitor of protein tyrosine phosphatase non-receptor type 22;Inhibitor of RTP Type M