3-{2-[5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]ethynyl}pyridine , CAS No.D608931, Inhibitor of AP2 associated kinase 1

Item Number

D608931

Grouped product items
SKU	Size	Availability	Price	Qty
D608931-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D608931-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Synonyms

compound 21b

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of AP2 associated kinase 1

Names and Identifiers

IUPAC Name	3-{2-[5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]ethynyl}pyridine
INCHI	InChI=1S/C22H17N3O2/c1-26-20-8-7-16(11-21(20)27-2)18-10-19-17(13-24-22(19)25-14-18)6-5-15-4-3-9-23-12-15/h3-4,7-14H,1-2H3,(H,24,25)
InChi Key	CJTVDIBZBUWIFC-UHFFFAOYSA-N
Canonical SMILES	COc1cc(ccc1OC)c1cnc2c(c1)c(C#Cc1cccnc1)c[nH]2
Isomeric SMILES	COC1=C(C=C(C=C1)C2=CC3=C(NC=C3C#CC4=CN=CC=C4)N=C2)OC
PubChem CID	138393295

References

1. Neveu G, Barouch-Bentov R, Ziv-Av A, Gerber D, Jacob Y, Einav S. (2012) Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.. PLoS Pathog, 8 (8): (e1002845). [PMID:22916011]
2. Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S. (2015) AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.. J Virol, 89 (8): (4387-404). [PMID:25653444]
3. Bekerman E, Neveu G, Shulla A, Brannan J, Pu SY, Wang S, Xiao F, Barouch-Bentov R, Bakken RR, Mateo R et al.. (2017) Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.. J Clin Invest, 127 (4): (1338-1352). [PMID:28240606]
4. Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R et al.. (2019) Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.. J Med Chem, 62 (12): (5810-5831). [PMID:31136173]

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Basic Description