Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S333476-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $21.90 | |
S333476-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
S333476-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $209.90 | |
S333476-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $729.90 |
a serotonin 5HT1-receptor agonist
Synonyms | AVP825 | AVP-825 | AB00698285_15 | Imigran Recovery | HMS2231B21 | Q416978 | Imitrex | AB00698285-12 | AVP 825 | 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methylmethanesulfonamide | 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Serotonin 1d (5-HT1d) receptor agonist |
Product Description |
Sumatriptan (GR 43175 free base) is a potent 5-hydroxytryptamine 1 (5-HT1) receptor agonist that crosses the blood-brain barrier and has anti-inflammatory activity with high affinity for 5-HT1D, 5-HT1B, and 5-HT1F receptors for use in acute migraines and acute myocardial infarction.
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pKa | pKₐ: 11.31 (Predicted), pKₐ: 9.49 (Predicted) |
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Ki Data | SR-1B: Ki= 5.5 nM (human); SR-2a: Ki= 7.3 nM (human); D2DR: Ki>218 nM (human); SR-1A: Ki= 230 nM (human); SR-1D: Ki= 376 nM (human) |
ALogP | 0.9 |
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IUPAC Name | 1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide |
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INCHI | InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 |
InChi Key | KQKPFRSPSRPDEB-UHFFFAOYSA-N |
Canonical SMILES | CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C |
Isomeric SMILES | CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C |
PubChem CID | 5358 |
Molecular Weight | 295.4 |
Beilstein | 6930870 |
PubChem CID | 5358 |
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DrugBank Ligand | DB00669 |
CAS Registry No. | 103628-46-2 |
ChEBI | CHEBI:10650 |
ChEMBL Ligand | CHEMBL128 |
DrugCentral Ligand | 2543 |
GPCRdb Ligand | sumatriptan |
Enter Lot Number to search for COA:
Solubility | Ethanol: 40 mg/mL (93.80 mM);DMSO: 80 mg/mL (270.82 mM), Sonication is recommended. |
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Sensitivity | Moisture sensitive |
Refractive Index | n20D1.61 (Predicted) |
Boil Point(°C) | 497.7° C at 760 mmHg (Predicted) |
Melt Point(°C) | 169-171° C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. |