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3,3′,5′-Triiodo-L-thyronine - 97%, high purity , CAS No.5817-39-0, Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β

Moligand™

≥97%

CAS#: 5817-39-0
Formula: C₁₅H₁₂I₃NO₄
Molecular Weight: 650.97
MDL number: MFCD00036864
PubChem CID: 644280

Item Number

T118717

Grouped product items
SKU	Size	Availability	Price
T118717-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$197.90
T118717-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$315.90
T118717-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$711.90
T118717-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,279.90
T118717-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,303.90

View related series

Thyroid hormone receptor-α Agonist Thyroid hormone receptor-β Agonist

Basic Description

Synonyms	Reverse T3 \| (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid \| 3,3',5'-Triiodo-L-thyronine \| 3,3,5-Triiodo-L-thyronine \| NCGC00344545-01 \| Reverse T3 \| Tox21_112797_1 \| 3,3',5'-T3 \| AKOS016843979 \| CS-W011412 \| Levothyroxine Imp
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β
Product Description	Product description： reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.

Associated Targets(Human)

THRA Tclin Thyroid hormone receptor alpha (0 Activities)

Discover Target: THRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta (1 Activities)

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A1 Tclin GABA transporter 1 (308 Activities)

Discover Target: SLC6A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1I2 Tchem Pregnane X receptor (6667 Activities)

Discover Target: NR1I2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (104 Activities)

Discover Target: SLCO1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SULT1B1 Tbio Sulfotransferase family cytosolic 1B member 1 (8 Activities)

Discover Target: SULT1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO4A1 Tbio Solute carrier organic anion transporter family member 4A1 (14 Activities)

Discover Target: SLCO4A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

Discover Target: Pkm

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc10a1 Bile acid transporter (65 Activities)

Discover Target: Slc10a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

Discover Target: Nr1i2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)

Discover Target: Slco1a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slco1c1 Solute carrier organic anion transporter family member 1C1 (11 Activities)

Discover Target: Slco1c1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC16A2 Monocarboxylate transporter 8 (28 Activities)

Discover Target: SLC16A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
INCHI	InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChi Key	HZCBWYNLGPIQRK-LBPRGKRZSA-N
Canonical SMILES	C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
Isomeric SMILES	C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
WGK Germany	3
PubChem CID	644280
Molecular Weight	650.97

Database links

PubChem CID	22069
ChEBI	CHEBI:28774
CAS Registry No.	5817-39-0
ChEMBL Ligand	CHEMBL1312
Wikipedia	Reverse triiodothyronine

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot Number	Certificate Type	Date	Item
C2401537	Certificate of Analysis	Feb 22, 2024	T118717
C2401538	Certificate of Analysis	Feb 22, 2024	T118717
C2401539	Certificate of Analysis	Feb 22, 2024	T118717
C2401540	Certificate of Analysis	Feb 22, 2024	T118717
C2401541	Certificate of Analysis	Feb 22, 2024	T118717
C2401542	Certificate of Analysis	Feb 22, 2024	T118717
C2401543	Certificate of Analysis	Feb 22, 2024	T118717
C2401544	Certificate of Analysis	Feb 22, 2024	T118717
C2401545	Certificate of Analysis	Feb 22, 2024	T118717
C2401546	Certificate of Analysis	Feb 22, 2024	T118717
E2421027	Certificate of Analysis	Feb 22, 2024	T118717
K2418050	Certificate of Analysis	Feb 22, 2024	T118717
B2217091	Certificate of Analysis	Feb 19, 2022	T118717

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Chemical and Physical Properties

Sensitivity	Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3

References

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10. Anita Kinne,Gunnar Kleinau,Carolin S Hoefig,Annette Grüters,Josef Köhrle,Gerd Krause,Ulrich Schweizer. (2010-07-16) Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.. The Journal of biological chemistry, 285 ((36)): (28054-28063). [PMID:20628049]
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12. Hidenori Nagao,Tetsuya Imazu,Hiroyuki Hayashi,Kenjo Takahashi,Kouichi Minato. (2011-04-12) Influence of thyroidectomy on thyroxine metabolism and turnover rate in rats.. The Journal of endocrinology, 210 ((1)): (117-123). [PMID:21478227]
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17. R Kassem,Z Liberty,M Babaev,H Trau,O Cohen. (2012-10-23) Harnessing the skin-thyroid connection for wound healing: a prospective controlled trial in guinea pigs.. Clinical and experimental dermatology, 37 ((8)): (850-856). [PMID:23083069]
18. Gergő Tóth,Károly Mazák,Sándor Hosztafi,József Kökösi,Béla Noszál. (2013-01-10) Species-specific lipophilicity of thyroid hormones and their precursors in view of their membrane transport properties.. Journal of pharmaceutical and biomedical analysis, 76 (112-118). [PMID:23298914]
19. Greet Roef,Youri Taes,Kaatje Toye,Stefan Goemaere,Tom Fiers,Alain Verstraete,Jean-Marc Kaufman. (2013-10-03) Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men.. European journal of endocrinology, 169 ((6)): (835-844). [PMID:24086088]
20. Shigeo Akiyama,Takayuki Ogiwara,Tomoyuki Aoki,Katsuhiko Tsunekawa,Osamu Araki,Masami Murakami. (2014-09-23) Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line.. Life sciences, 115 ((1-2)): (22-28). [PMID:25241124]
21. Patricia C Lisboa,Ellen P S Conceição,Elaine de Oliveira,Egberto G Moura. (2015-07-24) Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood.. The Journal of endocrinology, 226 ((3)): (219-226). [PMID:26203167]
22. Ivana Klopčič,Tijana Markovič,Irena Mlinarič-Raščan,Marija Sollner Dolenc. (2018-05-20) Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol.. Toxicology letters, 294 (95-104). [PMID:29777833]
23. Antonio C Bianco,Alexandra Dumitrescu,Balázs Gereben,Miriam O Ribeiro,Tatiana L Fonseca,Gustavo W Fernandes,Barbara M L C Bocco. (2019-04-30) Paradigms of Dynamic Control of Thyroid Hormone Signaling.. Endocrine reviews, 40 ((4)): (1000-1047). [PMID:31033998]
24. Josephine Jüttner,Arnold Szabo,Brigitte Gross-Scherf,Rei K Morikawa,Santiago B Rompani,Peter Hantz,Tamas Szikra,Federico Esposti,Cameron S Cowan,Arjun Bharioke,Claudia P Patino-Alvarez,Özkan Keles,Akos Kusnyerik,Thierry Azoulay,Dominik Hartl,Arnaud R Krebs,Dirk Schübeler,Rozina I Hajdu,Akos Lukats,Janos Nemeth,Zoltan Z Nagy,Kun-Chao Wu,Rong-Han Wu,Lue Xiang,Xiao-Long Fang,Zi-Bing Jin,David Goldblum,Pascal W Hasler,Hendrik P N Scholl,Jacek Krol,Botond Roska. (2019-07-10) Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans.. Nature neuroscience, 22 ((8)): (1345-1356). [PMID:31285614]
25. Kiyoshi Yamauchi,Shinpei Katsumata,Masanao Ozaki. (2019-11-22) A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S.. Genes & genetic systems, 94 ((5)): (207-217). [PMID:31748465]
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31. S Ruhla,A M Arafat,M O Weickert,M Osterhoff,F Isken,J Spranger,C Schöfl,A F H Pfeiffer,M Möhlig. (2010-11-26) T3/rT3-ratio is associated with insulin resistance independent of TSH.. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43 ((2)): (130-134). [PMID:21104580]
32. Tatsuya Kunisue,Jeffrey W Fisher,Kurunthachalam Kannan. (2010-12-03) Determination of six thyroid hormones in the brain and thyroid gland using isotope-dilution liquid chromatography/tandem mass spectrometry.. Analytical chemistry, 83 ((1)): (417-424). [PMID:21121614]
33. Katarzyna Skórkowska-Telichowska,Joanna Kosińska,Rafał Szymczak,Dominika Tuchendler,Renata Tuchendler,Artur Telichowski,Grzegorz Szajn,Marek Bolanowski. (2012-08-31) Comparison and assessment of thyroid morphology and function in inhabitants of Lower Silesia before and after administration of a single dose of iodine-containing contrast agent during cardiac intervention procedure.. Endokrynologia Polska, 63 ((4)): (294-299). [PMID:22933165]
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