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3,3′,5′-Triiodo-L-thyronine - 97%, high purity , CAS No.5817-39-0, Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β

Moligand™
≥97%

CAS#: 5817-39-0
Formula: C₁₅H₁₂I₃NO₄
Molecular Weight: 650.97
MDL number: MFCD00036864
PubChem CID: 644280

Item Number

T118717

Grouped product items
SKU	Size	Availability	Price
T118717-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$197.90
T118717-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$315.90
T118717-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$711.90
T118717-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,279.90
T118717-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,303.90

View related series

Thyroid hormone receptor-α Agonist Thyroid hormone receptor-β Agonist

Basic Description

Synonyms	5817-39-0\|3,3',5'-Triiodo-L-thyronine\|Reverse T3\|3,3',5'-Triiodothyronine\|REVERSE TRIIODOTHYRONINE\|(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid\|Isoliothyronine\|Triiodothyronine, reverse\|3,3,5-Triiodo-L-thyronine\|CHEBI:11684\|L
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β
Product Description	Product description： reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.

Associated Targets

SULT1B1 Tbio Sulfotransferase family cytosolic 1B member 1 0 Activities

Discover Target: SULT1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO4A1 Tbio Solute carrier organic anion transporter family member 4A1 0 Activities

Discover Target: SLCO4A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1C1 Tbio Solute carrier organic anion transporter family member 1C1 0 Activities

Discover Target: SLCO1C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 0 Activities

Discover Target: SLCO1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 0 Activities

Discover Target: RXRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A1 Tclin Sodium- and chloride-dependent GABA transporter 1 0 Activities

Discover Target: SLC6A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRA Tclin Thyroid hormone receptor alpha 0 Activities

Discover Target: THRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKM Tchem Pyruvate kinase PKM 0 Activities

Discover Target: PKM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A2 Tbio Monocarboxylate transporter 8 0 Activities

Discover Target: SLC16A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

Discover Target: NR1I2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 1 Activities

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC10A1 Tclin Sodium/bile acid cotransporter 0 Activities

Discover Target: SLC10A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
INCHI	InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChi Key	HZCBWYNLGPIQRK-LBPRGKRZSA-N
Canonical SMILES	C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
Isomeric SMILES	C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
WGK Germany	3
PubChem CID	644280
Molecular Weight	650.97

Database links

PubChem CID	22069
ChEBI	CHEBI:28774
CAS Registry No.	5817-39-0
ChEMBL Ligand	CHEMBL1312
Wikipedia	Reverse triiodothyronine

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
C2401537	Certificate of Analysis	Feb 22, 2024	T118717
C2401538	Certificate of Analysis	Feb 22, 2024	T118717
C2401539	Certificate of Analysis	Feb 22, 2024	T118717
C2401540	Certificate of Analysis	Feb 22, 2024	T118717
C2401541	Certificate of Analysis	Feb 22, 2024	T118717
C2401542	Certificate of Analysis	Feb 22, 2024	T118717
C2401543	Certificate of Analysis	Feb 22, 2024	T118717
C2401544	Certificate of Analysis	Feb 22, 2024	T118717
C2401545	Certificate of Analysis	Feb 22, 2024	T118717
C2401546	Certificate of Analysis	Feb 22, 2024	T118717
E2421027	Certificate of Analysis	Feb 22, 2024	T118717
B2217091	Certificate of Analysis	Feb 19, 2022	T118717

Chemical and Physical Properties

Sensitivity	Light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3

References

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22. Ivana Klopčič,Tijana Markovič,Irena Mlinarič-Raščan,Marija Sollner Dolenc. (2018-05-20) Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol.. Toxicology letters, 294 (95-104). [PMID:29777833]
23. Antonio C Bianco,Alexandra Dumitrescu,Balázs Gereben,Miriam O Ribeiro,Tatiana L Fonseca,Gustavo W Fernandes,Barbara M L C Bocco. (2019-04-30) Paradigms of Dynamic Control of Thyroid Hormone Signaling.. Endocrine reviews, 40 ((4)): (1000-1047). [PMID:31033998]
24. Josephine Jüttner,Arnold Szabo,Brigitte Gross-Scherf,Rei K Morikawa,Santiago B Rompani,Peter Hantz,Tamas Szikra,Federico Esposti,Cameron S Cowan,Arjun Bharioke,Claudia P Patino-Alvarez,Özkan Keles,Akos Kusnyerik,Thierry Azoulay,Dominik Hartl,Arnaud R Krebs,Dirk Schübeler,Rozina I Hajdu,Akos Lukats,Janos Nemeth,Zoltan Z Nagy,Kun-Chao Wu,Rong-Han Wu,Lue Xiang,Xiao-Long Fang,Zi-Bing Jin,David Goldblum,Pascal W Hasler,Hendrik P N Scholl,Jacek Krol,Botond Roska. (2019-07-10) Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans.. Nature neuroscience, 22 ((8)): (1345-1356). [PMID:31285614]
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