Basic Description

Synonyms	Triclocarban \| 101-20-2 \| 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea \| 3,4,4'-TRICHLOROCARBANILIDE \| Solubacter \| Procutene \| Cutisan \| Genoface \| Trilocarban \| Cusiter \| 3,4,4'-Trichlorodiphenylurea \| Trichlocarban \| Trichlorocarbanilide \| Triclocarbanum \| N-(4-Chlorophenyl)-N'-
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	3,4,4′-Trichlorocarbanilide(TCC) is employed as bacteriostat and antimicrobial agent in bar soaps3, cosmetics and other persona care prducts1.TCC is a toxic, persistent and potentially bioaccumulative polychlorinated binuclear aromatic urea pesticide. 3,4,4′-Trichlorocarbanilide was used to develop a sensitive analytical method to determine triclocarban and environmental phenols in breast milk using isotope dilution on-line solid-phase extraction coupled with HPLC–tandem mass spectrometry. 3,4,4′-Trichlorocarbanilide was used in quantitative structure-activity relationship (QSAR)analyses conducted to study the co-occurrence of Triclocarban and Triclosan in U.S. Water Resources.

Associated Targets(Human)

EPHX2 Tchem Bifunctional epoxide hydrolase 2 (1 Activities)

Discover Target: EPHX2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHX1 Tchem Epoxide hydrolase 1 (1 Activities)

Discover Target: EPHX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NLRP3 Tchem NACHT, LRR and PYD domains-containing protein 3 (1 Activities)

Discover Target: NLRP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 Activities)

Discover Target: PGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EPHX1 Tchem Epoxide hydrolase 1 (644 Activities)

Discover Target: EPHX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

Discover Target: GABRA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

Discover Target: ADRA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

Discover Target: PDE3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

Discover Target: HTR2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

Discover Target: TBXA2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

Discover Target: PDE4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

Discover Target: ADORA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 Activities)

Discover Target: HRH3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

Discover Target: AHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

Discover Target: NR1H4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EPHX2 Tchem Epoxide hydratase (3844 Activities)

Discover Target: EPHX2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)

Discover Target: UGT1A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Raji (5516 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BJ (6930 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 Activities)

Discover Target: UGT2B7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT2B17 Tbio UDP-glucuronosyltransferase 2B17 (197 Activities)

Discover Target: UGT2B17

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTT Tchem Huntingtin (19182 Activities)

Discover Target: HTT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNCA Tchem Alpha-synuclein (10960 Activities)

Discover Target: SNCA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT2B4 Tbio UDP-glucuronosyltransferase 2B4 (139 Activities)

Discover Target: UGT2B4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (172 Activities)

Discover Target: UGT2B15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)

Discover Target: UGT1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

INS1 (2867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Luciferin 4-monooxygenase (66902 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Epoxide hydrolase (46 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero C1008 (1716 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
INCHI	InChI=1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)
InChi Key	ICUTUKXCWQYESQ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)Cl)Cl
Isomeric SMILES	C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)Cl)Cl
WGK Germany	2
RTECS	FE1250000
PubChem CID	7547
Molecular Weight	315.58
Reaxy-Rn	2814890

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Melt Point(°C)	254-256°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09
Signal	Danger
Hazard Statements	H315:Causes skin irritation H411:Toxic to aquatic life with long lasting effects H225:Highly Flammable liquid and vapor H336:May cause drowsiness or dizziness H304:May be fatal if swallowed and enters airways H401:Toxic to aquatic life
Precautionary Statements	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P405:Store locked up. P501:Dispose of contents/container to ... P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment.
WGK Germany	2
RTECS	FE1250000
Reaxy-Rn	2814890
Merck Index	9654

Citations of This Product

1. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270]
2. Xiao Sihua, Wan Jinquan, Wang Yan, Yan Zhicheng, Ma Yongwen, Sun Jian, Tang Min, Cao Jianye, Chen Jinxin. (2023) Distribution, Sources, and Risk Assessment of Emerging Contaminants in the Effluents from Large-Scale Wastewater Treatment Plants in Guangzhou Central Districts, South China. WATER AIR AND SOIL POLLUTION, 234 (7): (1-17). [PMID:]
3. Tongchen Zhang, Huan Wu, Matin Naghizadeh, Qian Zheng, Sheying Dong. (2023) Magnetic Porous Polymer with −OH Groups as Sorbent for Excellent Extraction and Removal of Personal Care Products from Water. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 62 (22): (8873–8881). [PMID:]
4. Miao Lei, Chen Siyuan, Yang Hua, Hong Yaqi, Sun Liwen, Yang Jie, Sun Guanjun, Liu Yi, Li Chunyan, Zang Hailian, Cheng Yi. (2023) Enhanced bioremediation of triclocarban-contaminated soil by Rhodococcus rhodochrous BX2 and Pseudomonas sp. LY-1 immobilized on biochar and microbial community response. Frontiers in Microbiology, 14 [PMID:37065135]
5. Hao Wang, Hanlin Cui, Xiaodan Ma, Carolyn R. Cornell, Liying Zhang, Yijun Ren, Minghan Li, Ying Liu, Shu-Hong Gao, Zhiling Li, Ai-Jie Wang, Jizhong Zhou, Bin Liang. (2023) Molecular mechanism of adsorbing triclocarban by the activated sludge in wastewater treatment systems. CHEMICAL ENGINEERING JOURNAL, 463 (142431). [PMID:]
6. Zhuang Ke, Shen Wang, Wenqi Zhu, Fu Zhang, Wenjing Qiao, Jiandong Jiang, Kai Chen. (2022) Genetic bioaugmentation with triclocarban-catabolic plasmid effectively removes triclocarban from wastewater. ENVIRONMENTAL RESEARCH, 214 (113921). [PMID:35863452]
7. Li Chen, Tahir Maqbool, Wanyi Fu, Yulong Yang, Congyu Hou, Jianning Guo, Xihui Zhang. (2022) Highly efficient manganese (III) oxide submerged catalytic ceramic membrane for nonradical degradation of emerging organic compounds. SEPARATION AND PURIFICATION TECHNOLOGY, 295 (121272). [PMID:]
8. Chunyan Li, Yueling Sun, Guanjun Sun, Hailian Zang, Shanshan Sun, Xinyue Zhao, Ning Hou, Dapeng Li. (2022) An amidase and a novel phenol hydroxylase catalyze the degradation of the antibacterial agent triclocarban by Rhodococcus rhodochrous. JOURNAL OF HAZARDOUS MATERIALS, 430 (128444). [PMID:35183828]
9. Hao Li, Yikelamu Jilili, Weijun Zhen, Ling Zhao. (2022) Preparation, performance and structure-properties relationship of poly (lactic acid)/modified saponite nanocomposites based on thiol-ene click chemistry. Polymer-Plastics Technology and Materials, [PMID:]
10. Jiao Guan,Xin Yan,Yajing Zhao,Yinhe Sun,Xin Peng. (2018-05-20) Binding studies of triclocarban with bovine serum albumin: Insights from multi-spectroscopy and molecular modeling methods.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 202 (1-12). [PMID:29777928]

References

1. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270]
2. Xiao Sihua, Wan Jinquan, Wang Yan, Yan Zhicheng, Ma Yongwen, Sun Jian, Tang Min, Cao Jianye, Chen Jinxin. (2023) Distribution, Sources, and Risk Assessment of Emerging Contaminants in the Effluents from Large-Scale Wastewater Treatment Plants in Guangzhou Central Districts, South China. WATER AIR AND SOIL POLLUTION, 234 (7): (1-17). [PMID:]
3. Tongchen Zhang, Huan Wu, Matin Naghizadeh, Qian Zheng, Sheying Dong. (2023) Magnetic Porous Polymer with −OH Groups as Sorbent for Excellent Extraction and Removal of Personal Care Products from Water. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 62 (22): (8873–8881). [PMID:]
4. Miao Lei, Chen Siyuan, Yang Hua, Hong Yaqi, Sun Liwen, Yang Jie, Sun Guanjun, Liu Yi, Li Chunyan, Zang Hailian, Cheng Yi. (2023) Enhanced bioremediation of triclocarban-contaminated soil by Rhodococcus rhodochrous BX2 and Pseudomonas sp. LY-1 immobilized on biochar and microbial community response. Frontiers in Microbiology, 14 [PMID:37065135]
5. Hao Wang, Hanlin Cui, Xiaodan Ma, Carolyn R. Cornell, Liying Zhang, Yijun Ren, Minghan Li, Ying Liu, Shu-Hong Gao, Zhiling Li, Ai-Jie Wang, Jizhong Zhou, Bin Liang. (2023) Molecular mechanism of adsorbing triclocarban by the activated sludge in wastewater treatment systems. CHEMICAL ENGINEERING JOURNAL, 463 (142431). [PMID:]
6. Zhuang Ke, Shen Wang, Wenqi Zhu, Fu Zhang, Wenjing Qiao, Jiandong Jiang, Kai Chen. (2022) Genetic bioaugmentation with triclocarban-catabolic plasmid effectively removes triclocarban from wastewater. ENVIRONMENTAL RESEARCH, 214 (113921). [PMID:35863452]
7. Li Chen, Tahir Maqbool, Wanyi Fu, Yulong Yang, Congyu Hou, Jianning Guo, Xihui Zhang. (2022) Highly efficient manganese (III) oxide submerged catalytic ceramic membrane for nonradical degradation of emerging organic compounds. SEPARATION AND PURIFICATION TECHNOLOGY, 295 (121272). [PMID:]
8. Chunyan Li, Yueling Sun, Guanjun Sun, Hailian Zang, Shanshan Sun, Xinyue Zhao, Ning Hou, Dapeng Li. (2022) An amidase and a novel phenol hydroxylase catalyze the degradation of the antibacterial agent triclocarban by Rhodococcus rhodochrous. JOURNAL OF HAZARDOUS MATERIALS, 430 (128444). [PMID:35183828]
9. Hao Li, Yikelamu Jilili, Weijun Zhen, Ling Zhao. (2022) Preparation, performance and structure-properties relationship of poly (lactic acid)/modified saponite nanocomposites based on thiol-ene click chemistry. Polymer-Plastics Technology and Materials, [PMID:]
10. Jiao Guan,Xin Yan,Yajing Zhao,Yinhe Sun,Xin Peng. (2018-05-20) Binding studies of triclocarban with bovine serum albumin: Insights from multi-spectroscopy and molecular modeling methods.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 202 (1-12). [PMID:29777928]

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3,4,4'-Trichlorocarbanilide - 10mM in DMSO, high purity , CAS No.101-20-2