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3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide , CAS No.C608933, Inhibitor of sphingomyelin phosphodiesterase 1

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3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide , CAS No.C608933, Inhibitor of sphingomyelin phosphodiesterase 1

Moligand™

PubChem CID: 145996535

Item Number

C608933

Grouped product items
SKU	Size	Availability	Price	Qty
C608933-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608933-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

sphingomyelin phosphodiesterase 1 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of sphingomyelin phosphodiesterase 1

Associated Targets(Human)

SMPD1 Tchem Sphingomyelin phosphodiesterase (1 Activities)

Discover Target: SMPD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMPD2 Tchem Neutral sphingomyelinase (40 Activities)

Discover Target: SMPD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMPD1 Tchem Sphingomyelin phosphodiesterase (13561 Activities)

Discover Target: SMPD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide
INCHI	InChI=1S/C17H13ClN2O4/c18-14-7-5-13(6-8-14)12-3-1-11(2-4-12)10-23-16-9-15(24-20-16)17(21)19-22/h1-9,22H,10H2,(H,19,21)
InChi Key	XZENCCSBEQTERZ-UHFFFAOYSA-N
Canonical SMILES	ONC(=O)c1onc(c1)OCc1ccc(cc1)c1ccc(cc1)Cl
Isomeric SMILES	C1=CC(=CC=C1COC2=NOC(=C2)C(=O)NO)C3=CC=C(C=C3)Cl
PubChem CID	145996535

Database links

PubChem CID	145996535

Certificates

Certificate of Analysis(COA)

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References

1. Yang K, Yu J, Nong K, Wang Y, Niu A, Chen W, Dong J, Wang J. (2020) Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.. J Med Chem, 63 (3): (961-974). [PMID:31944697] [10.1021/op500134e]

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