Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D336170-10mg | 10mg | In stock | $248.90 | |
D336170-25mg | 25mg | In stock | $560.90 | |
D336170-50mg | 50mg | In stock | $1,008.90 | |
D336170-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,814.90 |
a granzyme, cathepsin G, and neutrolphil elastase inhibitor
Synonyms | 3,4-dichloroisocoumarin | 51050-59-0 | 3,4-Dichloro-1H-isochromen-1-one | 3,4-dichloroisochromen-1-one | 3,4 dichloroisocoumarin | 1H-2-Benzopyran-1-one, 3,4-dichloro- | 3,4dichloroisocoumarin | SD08W1HH6E | CHEMBL24983 | NSC-727363 | 3,4-Dcl | 1H-2-Benzopyran-1-one,3,4-dichlo |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Product does not compete with ATP. Reversible: no Primary Target serine proteases Cell permeable: no |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Effective concentration: 5-100 μM; t? = 20 min at pH 7.5. |
Product Description | 3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components|in vitro|. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin. |
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IUPAC Name | 3,4-dichloroisochromen-1-one |
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INCHI | InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H |
InChi Key | SUGXUUGGLDCZKB-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl |
Isomeric SMILES | C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl |
WGK Germany | 3 |
PubChem CID | 1609 |
Molecular Weight | 215.03 |
Beilstein | 6802625 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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C2214148 | Certificate of Analysis | Feb 15, 2022 | D336170 |
C2214149 | Certificate of Analysis | Feb 15, 2022 | D336170 |
C2214158 | Certificate of Analysis | Feb 15, 2022 | D336170 |
C2214190 | Certificate of Analysis | Feb 15, 2022 | D336170 |
Solubility | Soluble in DMF (10 mM), DMSO (10 mM), and water (partly miscible). |
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Refractive Index | n20D1.63 (Predicted) |
Boil Point(°C) | 304.74° C at 760 mmHg (Predicted) |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |