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3,4 Dichloroisocoumarin - 98%, high purity , CAS No.51050-59-0
a granzyme, cathepsin G, and neutrolphil elastase inhibitor
Basic Description Synonyms 3,4-dichloroisocoumarin|51050-59-0|3,4-Dichloro-1H-isochromen-1-one|3,4-dichloroisochromen-1-one|3,4 dichloroisocoumarin|1H-2-Benzopyran-1-one, 3,4-dichloro-|3,4dichloroisocoumarin|SD08W1HH6E|CHEMBL24983|NSC-727363|3,4-Dcl|1H-2-Benzopyran-1-one,3,4-dichlo Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Dry ice Product Description 3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components|in vitro|. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin.
Names and Identifiers IUPAC Name 3,4-dichloroisochromen-1-one INCHI InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H InChi Key SUGXUUGGLDCZKB-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl Isomeric SMILES C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl WGK Germany 3 PubChem CID 1609 Molecular Weight 215.03 Beilstein 6802625
Chemical and Physical Properties Solubility Soluble in DMF (10 mM), DMSO (10 mM), and water (partly miscible). Refractive Index n20D1.63 (Predicted) Boil Point(°C) 304.74° C at 760 mmHg (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS07 Signal Danger Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H301: Toxic if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
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C2214148