The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide , CAS No.615264-62-5
a cholesterol acyltransferase-1 and -2 inhibitor
Basic Description Synonyms 615264-62-5|3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide|CAY10485|Dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate|CHEMBL360400|SNEUAEKNRYBOTP-QFIPXVFZSA-N|DTXSID10653142|HMS3649L12|BDBM50151701|AKOS040754969| Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description 3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide inhibits human ACAT-1 and ACAT-2 (Acyl-Coenzyme A cyltransferase-1 and -2) equally with an IC|50|of about 60 μM. ACAT-1 and ACAT-2 catalyze the formation of long chain fatty acyl-coenzyme A and cholesterol esters from cholesterol, and may play a role in the development of atherosclerosis. This chemical inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively and also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.
Names and Identifiers IUPAC Name dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate INCHI InChI=1S/C27H27NO7/c29-23-13-11-19(15-24(23)30)12-14-25(31)28-22(27(33)35-18-21-9-5-2-6-10-21)16-26(32)34-17-20-7-3-1-4-8-20/h1-11,13,15,22,29-30H,12,14,16-18H2,(H,28,31)/t22-/m0/s1 InChi Key SNEUAEKNRYBOTP-QFIPXVFZSA-N Canonical SMILES C1=CC=C(C=C1)COC(=O)CC(C(=O)OCC2=CC=CC=C2)NC(=O)CCC3=CC(=C(C=C3)O)O Isomeric SMILES C1=CC=C(C=C1)COC(=O)C[C@@H](C(=O)OCC2=CC=CC=C2)NC(=O)CCC3=CC(=C(C=C3)O)O PubChem CID 35026724 Molecular Weight 477.5
Chemical and Physical Properties Solubility Soluble in water (0.25 mg/ml at 25° C), ethanol (~ 20 mg/ml), DMSO (~ 20 mg/ml), DMF (~ 20 mg/ml), and 1: 3 solution of ethanol:PBS (pH 7.2) (~ 0.25 mg/ml). Refractive Index n20D1.61 (Predicted) Boil Point(°C) ~727.6° C at 760 mmHg (Predicted)
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
