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3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide , CAS No.615264-62-5

CAS#: 615264-62-5
Formula: C₂₇H₂₇NO₇
Molecular Weight: 477.5
PubChem CID: 35026724

Item Number

D334625

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SKU	Size	Availability	Price
D334625-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$39.90
D334625-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90
D334625-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$319.90
D334625-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$558.90

a cholesterol acyltransferase-1 and -2 inhibitor

Basic Description

Synonyms	AKOS040754969 \| Dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate \| SR-01000946735 \| HMS3649L12 \| CAY10485 \| BDBM50151701 \| SNEUAEKNRYBOTP-QFIPXVFZSA-N \| Dibenzyl N-[3-(3,4-dihydroxyphenyl)propanoyl]-L-aspartate \| 3,4-Dihydroxy hydrocinn
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide inhibits human ACAT-1 and ACAT-2 (Acyl-Coenzyme A cyltransferase-1 and -2) equally with an IC\|50\|of about 60 μM. ACAT-1 and ACAT-2 catalyze the formation of long chain fatty acyl-coenzyme A and cholesterol esters from cholesterol, and may play a role in the development of atherosclerosis. This chemical inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively and also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.

Associated Targets(Human)

SOAT2 Tchem Acyl coenzyme A:cholesterol acyltransferase 2 (288 Activities)

Discover Target: SOAT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate
INCHI	InChI=1S/C27H27NO7/c29-23-13-11-19(15-24(23)30)12-14-25(31)28-22(27(33)35-18-21-9-5-2-6-10-21)16-26(32)34-17-20-7-3-1-4-8-20/h1-11,13,15,22,29-30H,12,14,16-18H2,(H,28,31)/t22-/m0/s1
InChi Key	SNEUAEKNRYBOTP-QFIPXVFZSA-N
Canonical SMILES	C1=CC=C(C=C1)COC(=O)CC(C(=O)OCC2=CC=CC=C2)NC(=O)CCC3=CC(=C(C=C3)O)O
Isomeric SMILES	C1=CC=C(C=C1)COC(=O)C[C@@H](C(=O)OCC2=CC=CC=C2)NC(=O)CCC3=CC(=C(C=C3)O)O
PubChem CID	35026724
Molecular Weight	477.5

Solubility

Soluble in water (0.25 mg/ml at 25° C), ethanol (~ 20 mg/ml), DMSO (~ 20 mg/ml), DMF (~ 20 mg/ml), and 1: 3 solution of ethanol:PBS (pH 7.2) (~ 0.25 mg/ml).

Refractive Index

n20D1.61 (Predicted)

Boil Point(°C)

~727.6° C at 760 mmHg (Predicted)

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3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide , CAS No.615264-62-5

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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