Basic Description

Synonyms	Dihydrocaffeic acid \| 1078-61-1 \| 3-(3,4-Dihydroxyphenyl)propionic acid \| 3-(3,4-Dihydroxyphenyl)propanoic acid \| 3,4-Dihydroxyhydrocinnamic acid \| Hydrocaffeic acid \| 3,4-Dihydroxyphenylpropionic acid \| Benzenepropanoic acid, 3,4-dihydroxy- \| 3,4-Dihydroxybenzenepropano
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Product Application： 3-(3,4-Dihydroxyphenyl)propionic acid it can be used to produce 3-(3,4-dihydroxy-phenyl)-propionic acid octyl ester by heating.

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAS2R39 Tchem Taste receptor type 2 member 39 (0 Activities)

Discover Target: TAS2R39

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (0 Activities)

Discover Target: SMAD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ANTXR2 Tchem Anthrax toxin receptor 2 (0 Activities)

Discover Target: ANTXR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-937 (7138 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Jurkat (10389 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

Discover Target: SMAD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ANTXR2 Tchem Anthrax toxin receptor 2 (35 Activities)

Discover Target: ANTXR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R39 Tchem Taste receptor type 2 member 39 (48 Activities)

Discover Target: TAS2R39

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

HD1 Histone deacetylase (38 Activities)

Discover Target: HD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human alphaherpesvirus 2 (4932 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cytomegalovirus (1023 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human alphaherpesvirus 1 (11089 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Echovirus E9 (43 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Coxsackievirus B3 (1096 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human adenovirus 2 (239 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Influenza A virus (11224 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human adenovirus 5 (897 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human poliovirus 1 strain Sabin (65 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pqsD 2-heptyl-4(1H)-quinolone synthase PqsD (77 Activities)

Discover Target: pqsD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-(3,4-dihydroxyphenyl)propanoic acid
INCHI	InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)
InChi Key	DZAUWHJDUNRCTF-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1CCC(=O)O)O)O
Isomeric SMILES	C1=CC(=C(C=C1CCC(=O)O)O)O
PubChem CID	348154
Molecular Weight	182.17

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Melt Point(°C)	136-140°

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

1. Zou Yilong. (2023) Cu2+, Cd2+, and Pb2+ ions adsorption from wastewater using polysaccharide hydrogels made of oxidized carboxymethyl cellulose and chitosan grafted with catechol groups. IRANIAN POLYMER JOURNAL, (1-10). [PMID:26334375]
2. Yiming Chen, Peng Ni, Renfeng Xu, Xueli Wang, Chunhui Fu, Kaixuan Wan, Yan Fang, Haiqing Liu, Yunxiang Weng. (2023) Tough and On-Demand Detachable Wet Tissue Adhesive Hydrogel Made from Catechol Derivatives with a Long Aliphatic Side Chain. Advanced Healthcare Materials, (2301913). [PMID:37533401]
3. Yu Chen, Yi Yang, Shuo Du, Jingli Ren, Hao Jiang, Lianbin Zhang, Jintao Zhu. (2023) Mitochondria-Targeting Upconversion Nanoparticles@MOF for Multiple-Enhanced Photodynamic Therapy in Hypoxic Tumor. ACS Applied Materials & Interfaces, 15 (30): (35884–35894). [PMID:37487181]
4. Meiling Zhang, Xiaoming Yu, Mengyi Sheng, Hua Chen. (2023) Mussel-inspired Self-assembly into Polymer Coatings of Different Molecular Weight Electrolytes for Enhanced Self-healing and Corrosion Properties. Chemistry-An Asian Journal, 18 (18): (e202300432). [PMID:37424055]
5. Ziwei Liang, Yuhui Wang, Jiapu Wang, Tao Xu, Shilong Ma, Qi Liu, Liqin Zhao, Yan Wei, Xiaojie Lian, Di Huang. (2023) Multifunctional Fe3O4-PEI@HA nanoparticles in the ferroptosis treatment of hepatocellular carcinoma through modulating reactive oxygen species. COLLOIDS AND SURFACES B-BIOINTERFACES, 227 (113358). [PMID:37207386]
6. Tang Xiaoduo, Ren Jingyan, Wei Xin, Wang Tao, Li Haiqiu, Sun Yihan, Liu Yang, Chi Mingli, Zhu Shoujun, Lu Laijin, Zhang Junhu, Yang Bai. (2023) Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch. Nature Communications, 14 (1): (1-14). [PMID:37105981]
7. Jianqun Wang, Wenxia Xu, Wenxuan Zhang, Junlong Da, Lixue Liu, Xiaowei Huang, Chubo Yang, Yuanbo Zhan, Han Jin, Ying Li, Bin Zhang. (2023) UV cross-linked injectable non-swelling dihydrocaffeic acid grafted chitosan hydrogel for promoting wound healing. CARBOHYDRATE POLYMERS, 314 (120926). [PMID:37173025]
8. Lin Li, Dongfan Chen, Jiale Chen, Chao Yang, Youyun Zeng, Ting Jin, Yanmei Zhang, Xiaoyu Sun, Hongli Mao, Zhixiang Mu, Xinkun Shen, Zhanwei Ruan, Xiaojun Cai. (2023) Gelatin and catechol-modified quaternary chitosan cotton dressings with rapid hemostasis and high-efficiency antimicrobial capacity to manage severe bleeding wounds. MATERIALS & DESIGN, 229 (111927). [PMID:]
9. Li Xiong, Chen Zhou, Lei Tong, Xiaowen Han, Yaping Zou, Zuqin Dong, Jie Liang, Yafang Chen, Yujiang Fan. (2023) Injectable hydrogels of recombinant human collagen type III and chitosan with antibacterial and antioxidative activities for wound healing. Journal of Materials Chemistry B, 11 (18): (4131-4142). [PMID:37114495]
10. Xi Wenke, Zhang Ge, Xue Jingquan, Li Juan, Liu Yu, Wang Jianjun, Yang Wenjiang. (2023) A novel superparamagnetic iron oxide nanoparticles-based SPECT/MRI dual-modality probe for tumor imaging. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 332 (4): (1237-1244). [PMID:]
11. Yuhui Wang, Shilong Ma, Xuanyu Liu, Yan Wei, Haofeng Xu, Ziwei Liang, Yinchun Hu, Xiaojie Lian, Di Huang. (2023) Hyaluronic acid mediated Fe3O4 nanocubes reversing the EMT through targeted cancer stem cell. COLLOIDS AND SURFACES B-BIOINTERFACES, 222 (113071). [PMID:36473370]
12. Youyu Jia, Feng Shi, Hongying Li, Zhikun Yan, Jiwei Xu, Jiale Gao, Xiaoli Wu, Yifan Li, Jingtao Wang, Bing Zhang. (2022) Facile Ionization of the Nanochannels of Lamellar Membranes for Stable Ionic Liquid Immobilization and Efficient CO2 Separation. ACS Nano, 16 (9): (14379–14389). [PMID:36095242]
13. Bingyang Lu, Xiao Han, Dan Zou, Xiao Luo, Li Liu, Jingyue Wang, Manfred F. Maitz, Ping Yang, Nan Huang, Ansha Zhao. (2022) Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation. Materials Today Bio, 16 (100392). [PMID:36033376]
14. Bo Ling, Yaguang Wang, Ruo Mi, Di Wang, Hongqi Chen, Xiaohu Li, Ye Zhang, Lun Wang. (2022) Multimodal Imaging and Synergetic Chemodynamic/Photodynamic Therapy Achieved Using an NaGdF4,Yb,Er@ NaGdF4,Yb,Tm@NaYF4@Fe-MOFs Nanocomposite. Chemistry-An Asian Journal, 17 (14): (e202200161). [PMID:35485259]
15. Lu Haibin, Li Xiaoling, Zhang Mu, Xu Changpeng, Li Wenqiang, Wan Lei. (2022) Antibacterial Cellulose Nanocrystal-Incorporated Hydrogels With Satisfactory Vascularization for Enhancing Skin Regeneration. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35557856]
16. Yang Li,Ying Peng,Mengyue Wang,Guisheng Zhou,Yulong Zhang,Xiaobo Li. (2016-09-19) Rapid screening and identification of the differences between metabolites of Cistanche deserticola and C. tubulosa water extract in rats by UPLC-Q-TOF-MS combined pattern recognition analysis.. Journal of pharmaceutical and biomedical analysis, 131 (364-372). [PMID:27639339]
17. Yang Li,Ying Peng,Mengyue Wang,Pengfei Tu,Xiaobo Li. (2017-08-05) Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes.. Journal of agricultural and food chemistry, 65 ((34)): (7447-7456). [PMID:28771352]

References

1. Zou Yilong. (2023) Cu2+, Cd2+, and Pb2+ ions adsorption from wastewater using polysaccharide hydrogels made of oxidized carboxymethyl cellulose and chitosan grafted with catechol groups. IRANIAN POLYMER JOURNAL, (1-10). [PMID:26334375]
2. Yiming Chen, Peng Ni, Renfeng Xu, Xueli Wang, Chunhui Fu, Kaixuan Wan, Yan Fang, Haiqing Liu, Yunxiang Weng. (2023) Tough and On-Demand Detachable Wet Tissue Adhesive Hydrogel Made from Catechol Derivatives with a Long Aliphatic Side Chain. Advanced Healthcare Materials, (2301913). [PMID:37533401]
3. Yu Chen, Yi Yang, Shuo Du, Jingli Ren, Hao Jiang, Lianbin Zhang, Jintao Zhu. (2023) Mitochondria-Targeting Upconversion Nanoparticles@MOF for Multiple-Enhanced Photodynamic Therapy in Hypoxic Tumor. ACS Applied Materials & Interfaces, 15 (30): (35884–35894). [PMID:37487181]
4. Meiling Zhang, Xiaoming Yu, Mengyi Sheng, Hua Chen. (2023) Mussel-inspired Self-assembly into Polymer Coatings of Different Molecular Weight Electrolytes for Enhanced Self-healing and Corrosion Properties. Chemistry-An Asian Journal, 18 (18): (e202300432). [PMID:37424055]
5. Ziwei Liang, Yuhui Wang, Jiapu Wang, Tao Xu, Shilong Ma, Qi Liu, Liqin Zhao, Yan Wei, Xiaojie Lian, Di Huang. (2023) Multifunctional Fe3O4-PEI@HA nanoparticles in the ferroptosis treatment of hepatocellular carcinoma through modulating reactive oxygen species. COLLOIDS AND SURFACES B-BIOINTERFACES, 227 (113358). [PMID:37207386]
6. Tang Xiaoduo, Ren Jingyan, Wei Xin, Wang Tao, Li Haiqiu, Sun Yihan, Liu Yang, Chi Mingli, Zhu Shoujun, Lu Laijin, Zhang Junhu, Yang Bai. (2023) Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch. Nature Communications, 14 (1): (1-14). [PMID:37105981]
7. Jianqun Wang, Wenxia Xu, Wenxuan Zhang, Junlong Da, Lixue Liu, Xiaowei Huang, Chubo Yang, Yuanbo Zhan, Han Jin, Ying Li, Bin Zhang. (2023) UV cross-linked injectable non-swelling dihydrocaffeic acid grafted chitosan hydrogel for promoting wound healing. CARBOHYDRATE POLYMERS, 314 (120926). [PMID:37173025]
8. Lin Li, Dongfan Chen, Jiale Chen, Chao Yang, Youyun Zeng, Ting Jin, Yanmei Zhang, Xiaoyu Sun, Hongli Mao, Zhixiang Mu, Xinkun Shen, Zhanwei Ruan, Xiaojun Cai. (2023) Gelatin and catechol-modified quaternary chitosan cotton dressings with rapid hemostasis and high-efficiency antimicrobial capacity to manage severe bleeding wounds. MATERIALS & DESIGN, 229 (111927). [PMID:]
9. Li Xiong, Chen Zhou, Lei Tong, Xiaowen Han, Yaping Zou, Zuqin Dong, Jie Liang, Yafang Chen, Yujiang Fan. (2023) Injectable hydrogels of recombinant human collagen type III and chitosan with antibacterial and antioxidative activities for wound healing. Journal of Materials Chemistry B, 11 (18): (4131-4142). [PMID:37114495]
10. Xi Wenke, Zhang Ge, Xue Jingquan, Li Juan, Liu Yu, Wang Jianjun, Yang Wenjiang. (2023) A novel superparamagnetic iron oxide nanoparticles-based SPECT/MRI dual-modality probe for tumor imaging. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 332 (4): (1237-1244). [PMID:]
11. Yuhui Wang, Shilong Ma, Xuanyu Liu, Yan Wei, Haofeng Xu, Ziwei Liang, Yinchun Hu, Xiaojie Lian, Di Huang. (2023) Hyaluronic acid mediated Fe3O4 nanocubes reversing the EMT through targeted cancer stem cell. COLLOIDS AND SURFACES B-BIOINTERFACES, 222 (113071). [PMID:36473370]
12. Youyu Jia, Feng Shi, Hongying Li, Zhikun Yan, Jiwei Xu, Jiale Gao, Xiaoli Wu, Yifan Li, Jingtao Wang, Bing Zhang. (2022) Facile Ionization of the Nanochannels of Lamellar Membranes for Stable Ionic Liquid Immobilization and Efficient CO2 Separation. ACS Nano, 16 (9): (14379–14389). [PMID:36095242]
13. Bingyang Lu, Xiao Han, Dan Zou, Xiao Luo, Li Liu, Jingyue Wang, Manfred F. Maitz, Ping Yang, Nan Huang, Ansha Zhao. (2022) Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation. Materials Today Bio, 16 (100392). [PMID:36033376]
14. Bo Ling, Yaguang Wang, Ruo Mi, Di Wang, Hongqi Chen, Xiaohu Li, Ye Zhang, Lun Wang. (2022) Multimodal Imaging and Synergetic Chemodynamic/Photodynamic Therapy Achieved Using an NaGdF4,Yb,Er@ NaGdF4,Yb,Tm@NaYF4@Fe-MOFs Nanocomposite. Chemistry-An Asian Journal, 17 (14): (e202200161). [PMID:35485259]
15. Lu Haibin, Li Xiaoling, Zhang Mu, Xu Changpeng, Li Wenqiang, Wan Lei. (2022) Antibacterial Cellulose Nanocrystal-Incorporated Hydrogels With Satisfactory Vascularization for Enhancing Skin Regeneration. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35557856]
16. Yang Li,Ying Peng,Mengyue Wang,Guisheng Zhou,Yulong Zhang,Xiaobo Li. (2016-09-19) Rapid screening and identification of the differences between metabolites of Cistanche deserticola and C. tubulosa water extract in rats by UPLC-Q-TOF-MS combined pattern recognition analysis.. Journal of pharmaceutical and biomedical analysis, 131 (364-372). [PMID:27639339]
17. Yang Li,Ying Peng,Mengyue Wang,Pengfei Tu,Xiaobo Li. (2017-08-05) Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes.. Journal of agricultural and food chemistry, 65 ((34)): (7447-7456). [PMID:28771352]

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3,4-Dihydroxyhydrocinnamic acid - 10mM in DMSO, high purity , CAS No.1078-61-1