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3-(4-Isopropylbenzylidenyl)indolin-2-one - ≥98%, high purity , CAS No.186611-55-2
a non-selective inhibitor of RTKs
Basic Description Specifications & Purity ≥98% Storage Temp Store at 2-8°C Shipped In Wet ice Product Description 3-(4-Isopropylbenzylidenyl)indolin-2-one is a non-selective inhibitor of receptor tyrosine kinases (RTKs). It inhibits PDGFR, FLK-1, EGFR, HER-2, IGF-1R RTKs (IC|50|~5-25μM). 3-(4-Isopropylbenzylidenyl)indolin-2-one consists primarily of the E-isomer; contains ~5% of the Z-isomer.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3E)-3-[(4-propan-2-ylphenyl)methylidene]-1H-indol-2-one INCHI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+ InChi Key IRQQWCZKCUQNSO-LFIBNONCSA-N Canonical SMILES CC(C)C1=CC=C(C=C1)C=C2C3=CC=CC=C3NC2=O Isomeric SMILES CC(C)C1=CC=C(C=C1)/C=C/2\C3=CC=CC=C3NC2=O PubChem CID 1538822 Molecular Weight 263.4
Chemical and Physical Properties Solubility Soluble in DMSO (>80mg/ml) or methanol (8mg/ml). Sparingly soluble in aqueous buffers (25μg/ml)
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