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3-(4-Isopropylbenzylidenyl)­indolin-2-one - ≥98%, high purity , CAS No.186611-55-2

  • ≥98%
Item Number
I337822
Grouped product items
SKUSizeAvailabilityPrice Qty
I337822-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$37.90
I337822-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$195.90
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a non-selective inhibitor of RTKs

Basic Description

Specifications & Purity≥98%
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

3-(4-Isopropylbenzylidenyl)indolin-2-one is a non-selective inhibitor of receptor tyrosine kinases (RTKs). It inhibits PDGFR, FLK-1, EGFR, HER-2, IGF-1R RTKs (IC|50|~5-25μM). 3-(4-Isopropylbenzylidenyl)indolin-2-one consists primarily of the E-isomer; contains ~5% of the Z-isomer.

Associated Targets(Human)

DHFR Tclin Dihydrofolate reductase (3072 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLB1 Tchem Beta-galactosidase (339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FLT1 Tclin Vascular endothelial growth factor receptor 1 (6262 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTRC Tchem Chymotrypsin C (381 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (3E)-3-[(4-propan-2-ylphenyl)methylidene]-1H-indol-2-one
INCHI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
InChi Key IRQQWCZKCUQNSO-LFIBNONCSA-N
Canonical SMILES CC(C)C1=CC=C(C=C1)C=C2C3=CC=CC=C3NC2=O
Isomeric SMILES CC(C)C1=CC=C(C=C1)/C=C/2\C3=CC=CC=C3NC2=O
PubChem CID 1538822
Molecular Weight 263.4

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (>80mg/ml) or methanol (8mg/ml). Sparingly soluble in aqueous buffers (25μg/ml)

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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