3,5,7,8-tetrahydro-2-methyl-4h-thiopyrano(4,3-d)pyrimidin-4-one - 98%(HPLC), high purity , CAS No.284028-90-6

  • ≥98%(HPLC)
Item Number
T120464
Grouped product items
SKUSizeAvailabilityPrice Qty
T120464-5mg
5mg
In stock
$58.90
T120464-10mg
10mg
In stock
$98.90
T120464-25mg
25mg
In stock
$197.90
T120464-50mg
50mg
In stock
$296.90
T120464-100mg
100mg
In stock
$444.90

Potent, brain-penetrant and water-soluble PARP inhibitor

Basic Description

Synonyms284028-90-6 | 7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one | DR 2313 | DR2313 | PARP Inhibitor XI, DR2313 | Parp inhibitor xi | 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one | DR-2313 | 2-Methyl-3,5,7,8-Tetrahydro-4h-Thiopyrano[4,3-D]pyr
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsPotent, brain-penetrant, and water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor. IC50 values are 0.20 and 0.24 µM for PARP-1 and PARP-2, respectively.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PARP1 Tclin Poly [ADP-ribose] polymerase-1 (6206 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP3 Tclin Poly [ADP-ribose] polymerase 3 (206 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP14 Tchem Poly [ADP-ribose] polymerase 14 (380 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP15 Tchem Poly [ADP-ribose] polymerase 15 (178 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
INCHI InChI=1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChi Key HRYKZAKEAVZGJD-UHFFFAOYSA-N
Canonical SMILES CC1=NC2=C(CSCC2)C(=O)N1
Isomeric SMILES CC1=NC2=C(CSCC2)C(=O)N1
WGK Germany 3
PubChem CID 135522417
Molecular Weight 182.24

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Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
I2216384Certificate of AnalysisJun 23, 2022 T120464
I2216386Certificate of AnalysisJun 23, 2022 T120464
I2216395Certificate of AnalysisJun 23, 2022 T120464
I2216410Certificate of AnalysisJun 23, 2022 T120464
I2216479Certificate of AnalysisJun 23, 2022 T120464

Chemical and Physical Properties

Sensitivitylight sensitive

Safety and Hazards(GHS)

WGK Germany 3

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