3,5-Dihydroxybenzoic acid - 97%, high purity , CAS No.99-10-5, Agonist of HCA 1 receptor

6 Citations
Item Number
D104386
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D104386-5g
5g
In stock
$10.90
D104386-25g
25g
In stock
$41.90
D104386-100g
100g
In stock
$150.90
D104386-250g
250g
In stock
$338.90
D104386-500g
500g
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$609.90
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HCA1 receptor Agonist

Basic Description

SynonymsAI3-52338 | BDBM50336490 | HY-W015560 | SCHEMBL28106 | 3,5-Dihydroxybenzoicacid | 34D | alpha-Resorcylic acid | GTPL5783 | FT-0602267 | 3,5-Dihydroxybenzoic acid, 97% | DTXSID8059184 | F0001-2331 | 3,5-Dihydroxybenzoic acid (ACD/Name 4.0) | P16552 | NSC 2
Specifications & PurityMoligand™, ≥97%
Storage TempProtected from light
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of HCA 1 receptor

Associated Targets(Human)

CA1 Tclin Carbonic anhydrase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA14 Tclin Carbonic anhydrase 14 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HCAR1 Tchem Hydroxycarboxylic acid receptor 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALB Tchem Serum albumin (2651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TLR2 Tchem Toll-like receptor 2 (975 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCAR1 Tchem G-protein coupled receptor 81 (382 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ca7 Carbonic anhydrase VII (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Carbonic anhydrase (69 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hylobius abietis (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488180424
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180424
IUPAC Name 3,5-dihydroxybenzoic acid
INCHI InChI=1S/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11)
InChi Key UYEMGAFJOZZIFP-UHFFFAOYSA-N
Canonical SMILES C1=C(C=C(C=C1O)O)C(=O)O
Isomeric SMILES C1=C(C=C(C=C1O)O)C(=O)O
WGK Germany 1
RTECS VH3708000
PubChem CID 7424
Molecular Weight 154.12
Beilstein 2207864

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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17 results found

Lot NumberCertificate TypeDateItem
G23051188Certificate of AnalysisJul 10, 2023 D104386
G23051183Certificate of AnalysisJul 10, 2023 D104386
G23051182Certificate of AnalysisJul 10, 2023 D104386
G23051180Certificate of AnalysisJul 10, 2023 D104386
F23051181Certificate of AnalysisJul 10, 2023 D104386
B2328421Certificate of AnalysisFeb 06, 2023 D104386
B2328431Certificate of AnalysisFeb 06, 2023 D104386
B2328430Certificate of AnalysisFeb 06, 2023 D104386
B2328429Certificate of AnalysisFeb 06, 2023 D104386
B2328428Certificate of AnalysisFeb 06, 2023 D104386
B2328427Certificate of AnalysisFeb 06, 2023 D104386
B2328425Certificate of AnalysisFeb 06, 2023 D104386
B2328424Certificate of AnalysisFeb 06, 2023 D104386
B2328422Certificate of AnalysisFeb 06, 2023 D104386
L1411017Certificate of AnalysisSep 19, 2022 D104386
H1809035Certificate of AnalysisJun 15, 2022 D104386
A2330473Certificate of AnalysisJun 10, 2021 D104386

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Chemical and Physical Properties

SolubilitySoluble in 50 mg/mL, 95% Ethanol.
SensitivityLight sensitive.Moisture sensitive.
Flash Point(°F)392 °F
Flash Point(°C)≥200℃
Melt Point(°C)232-233°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 1
RTECS VH3708000

Related Documents

Citations of This Product

1. Dali Fu, Haodong Wang, Tan Wang, Chunming Xu, Yehua Han.  (2023)  Structural insights into variation of intramolecular acid site using phase transition experiments and computation.  AICHE JOURNAL,  70  (4): (e18342).  [PMID:]
2. Diqin Zhang, Yu Zhao, Bin Guo, Zhen Zhang, Dejiao Hu, Zhen Wang, Jianhua Zhu, Yan Ye, Yuxia Zhao.  (2023)  Acrylate dendritic monomers for fabricating holographic data storage media with high performance.  EUROPEAN POLYMER JOURNAL,  198  (112436).  [PMID:21418524]
3. Hui Yang, Guoming Yuan, Enxiang Jiao, Kunxin Wang, WenJie Diao, Zhao Li, Kun Wu, Jun Shi.  (2023)  Low dielectric constant and high thermal stability of liquid crystal epoxy polymers based on functionalized poly(phenylene oxide).  EUROPEAN POLYMER JOURNAL,  198  (112378).  [PMID:]
4. Naijie Wang, Xiangqun Chen, Qiu Sun, Ying Song, Tiezhu Xin.  (2023)  Fast Li+ Transport Polyurethane-Based Single-Ion Conducting Polymer Electrolyte with Sulfonamide Side chains in the Hard Segment for Lithium Metal Batteries.  ACS Applied Materials & Interfaces,  15  (33): (39837–39846).  [PMID:37552620]
5. Jian Yao, Lun Gui, Qizhang Long.  (2022)  A chlorogenic acid esterase from a metagenomic library with unique substrate specificity and its application in caffeic and ferulic acid production from agricultural byproducts.  BIOCATALYSIS AND BIOTRANSFORMATION,      [PMID:]
6. Qiqin Wang, Lingjue Sun, Huihui Wu, Ning Deng, Xianglong Zhao, Jingwei Zhou, Tingting Zhang, Hai Han, Zhengjin Jiang.  (2022)  Rapid fabrication of zwitterionic sulfobetaine vinylimidazole-based monoliths via photoinitiated copolymerization for hydrophilic interaction chromatography.  Journal of Pharmaceutical Analysis,  12  (783).  [PMID:36320596]

References

1. Liu C, Kuei C, Zhu J, Yu J, Zhang L, Shih A, Mirzadegan T, Shelton J, Sutton S, Connelly MA et al..  (2012)  3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes..  J Pharmacol Exp Ther,  341  (3): (794-801).  [PMID:22434674]
2. M J Miller,J E Ream,M C Walker,J A Sikorski.  (1994-05-01)  Functionalized 3,5-dihydroxybenzoates as potent novel inhibitors of EPSP synthase..  Bioorganic & medicinal chemistry,  ((5)): (331-338).  [PMID:7922144]
3. María C Terrón,Tania González,José M Carbajo,Susana Yagüe,Ainhoa Arana-Cuenca,Alejandro Téllez,Alan D W Dobson,Aldo E González.  (2004-09-03)  Structural close-related aromatic compounds have different effects on laccase activity and on lcc gene expression in the ligninolytic fungus Trametes sp. I-62..  Fungal genetics and biology : FG & B,  41  ((10)): (954-962).  [PMID:15341917]
4. Sunil Varughese,Venkateswara Rao Pedireddi.  (2005-10-27)  A competitive molecular recognition study: syntheses and analysis of supramolecular assemblies of 3,5-dihydroxybenzoic acid and its bromo derivative with some N-donor compounds..  Chemistry (Weinheim an der Bergstrasse, Germany),  12  ((6)): (1597-1609).  [PMID:16250059]
5. Seetharaman Vaidyanathan,Simon Gaskell,Royston Goodacre.  (2006-03-17)  Matrix-suppressed laser desorption/ionisation mass spectrometry and its suitability for metabolome analyses..  Rapid communications in mass spectrometry : RCM,  20  ((8)): (1192-1198).  [PMID:16541414]
6. Abigail E Wolfe,Majbritt Thymark,Samuel G Gattis,Rebecca L Fagan,Yu-chen Hu,Eva Johansson,Susan Arent,Sine Larsen,Bruce A Palfey.  (2007-04-21)  Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis..  Biochemistry,  46  ((19)): (5741-5753).  [PMID:17444658]
7. Anja Koskela,Anna-Maria Linko-Parvinen,Perttu Hiisivuori,Adile Samaletdin,Afaf Kamal-Eldin,Matti J Tikkanen,Herman Adlercreutz.  (2007-05-15)  Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection..  Clinical chemistry,  53  ((7)): (1380-1383).  [PMID:17495018]
8. Wendy R Russell,Lorraine Scobbie,Garry G Duthie,Andrew Chesson.  (2008-03-04)  Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids..  Bioorganic & medicinal chemistry,  16  ((8)): (4589-4593).  [PMID:18314336]
9. Anja Koskela,Adile Samaletdin,Mylène Aubertin-Leheudre,Herman Adlercreutz.  (2008-08-12)  Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detection..  Journal of agricultural and food chemistry,  56  ((17)): (7678-7681).  [PMID:18690683]
10. Laurent Camont,Fabrice Collin,Catherine Marchetti,Daniel Jore,Monique Gardes-Albert,Dominique Bonnefont-Rousselot.  (2010-02-16)  Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of trans-resveratrol in aqueous solutions..  Rapid communications in mass spectrometry : RCM,  24  ((5)): (634-642).  [PMID:20155763]
11. Matti Marklund,Rikard Landberg,Per Aman,Afaf Kamal-Eldin.  (2010-03-13)  Determination of alkylresorcinol metabolites in human urine by gas chromatography-mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  878  ((11-12)): (888-894).  [PMID:20223713]
12. Nighat Sultana,Musarrat Akhter,Zakia Khatoon.  (2010-03-23)  Nematicidal natural products from the aerial parts of Rubus niveus..  Natural product research,  24  ((5)): (407-415).  [PMID:20306362]
13. Takeshi Ishii,Taiki Mori,Tatsuya Ichikawa,Maiko Kaku,Koji Kusaka,Yoshinori Uekusa,Mitsugu Akagawa,Yoshiyuki Aihara,Takumi Furuta,Toshiyuki Wakimoto,Toshiyuki Kan,Tsutomu Nakayama.  (2010-07-06)  Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin..  Bioorganic & medicinal chemistry,  18  ((14)): (4892-4896).  [PMID:20598557]
14. Yasuyo Seshime,Praveen Rao Juvvadi,Katsuhiko Kitamoto,Yutaka Ebizuka,Takamasa Nonaka,Isao Fujii.  (2010-07-16)  Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid..  Bioorganic & medicinal chemistry letters,  20  ((16)): (4785-4788).  [PMID:20630753]
15. Serdar Durdagi,Murat Şentürk,Deniz Ekinci,Halis Türker Balaydın,Süleyman Göksu,Ö İrfan Küfrevioğlu,Alessio Innocenti,Andrea Scozzafava,Claudiu T Supuran.  (2011-02-02)  Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site..  Bioorganic & medicinal chemistry,  19  ((4)): (1381-1389).  [PMID:21282059]
16. Matti Marklund,Rikard Landberg,Per Åman,Afaf Kamal-Eldin.  (2011-02-22)  Comparison of gas chromatography-mass spectrometry and high-performance liquid chromatography with coulometric electrode array detection for determination of alkylresorcinol metabolites in human urine..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  879  ((9-10)): (647-651).  [PMID:21334988]
17. Sevim Beyza Oztürk Sarikaya,Fevzi Topal,Murat Sentürk,Ilhami Gülçin,Claudiu T Supuran.  (2011-06-15)  In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds..  Bioorganic & medicinal chemistry letters,  21  ((14)): (4259-4262).  [PMID:21669522]
18. Yingdong Zhu,Kelly L Shurlknight,Xiaoxin Chen,Shengmin Sang.  (2013-11-22)  Identification and pharmacokinetics of novel alkylresorcinol metabolites in human urine, new candidate biomarkers for whole-grain wheat and rye intake..  The Journal of nutrition,  144  ((2)): (114-122).  [PMID:24259554]
19. Wojciech Ostrowski,Anna Wojakowska,Magdalena Grajzer,Maciej Stobiecki.  (2014-07-27)  Mass spectrometric behavior of phenolic acids standards and their analysis in the plant samples with LC/ESI/MS system..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  967  (21-27).  [PMID:25063924]
20. Maria Luiza Zeraik,Maicon S Petrônio,Dyovani Coelho,Luis Octavio Regasini,Dulce H S Silva,Luiz Marcos da Fonseca,Sergio A S Machado,Vanderlan S Bolzani,Valdecir F Ximenes.  (2014-10-24)  Improvement of pro-oxidant capacity of protocatechuic acid by esterification..  PloS one,  ((10)): (e110277-e110277).  [PMID:25340774]
21. Debabrata Sircar,Mariam M Gaid,Cornelia Chizzali,Dennis Reckwell,David Kaufholdt,Till Beuerle,Giovanni A L Broggini,Henryk Flachowsky,Benye Liu,Robert Hänsch,Ludger Beerhues.  (2015-04-12)  Biphenyl 4-Hydroxylases Involved in Aucuparin Biosynthesis in Rowan and Apple Are Cytochrome P450 736A Proteins..  Plant physiology,  168  ((2)): (428-442).  [PMID:25862456]
22. Ruiqin Yi,Hirofumi Narimoto,Miku Nozoe,Tsuyoshi Ichiyanagi.  (2015-08-04)  Convergent synthesis of 4,5-branched inner-core oligosaccharides of lipopoly- and lipooligosaccharides..  Bioscience, biotechnology, and biochemistry,  79  ((12)): (1931-1945).  [PMID:26235297]
23. Y Matsumoto,M Ohsako.  (1992-05-01)  Transport of drugs through human erythrocyte membranes: pH dependence of drug transport through labeled human erythrocytes in the presence of band 3 protein inhibitor..  Journal of pharmaceutical sciences,  81  ((5)): (428-431).  [PMID:1403673]
24. B Z Zhu,N Kitrossky,M Chevion.  (2000-04-25)  Evidence for production of hydroxyl radicals by pentachlorophenol metabolites and hydrogen peroxide: A metal-independent organic Fenton reaction..  Biochemical and biophysical research communications,  270  ((3)): (942-946).  [PMID:10772930]
25. Mariko Yoshida,Takeshi Hiromoto,Keiichi Hosokawa,Hiroshi Yamaguchi,Shinsuke Fujiwara.  (2007-08-21)  Ligand specificity of MobR, a transcriptional regulator for the 3-hydroxybenzoate hydroxylase gene of Comamonas testosteroni KH122-3s..  Biochemical and biophysical research communications,  362  ((2)): (275-280).  [PMID:17707338]
26. Silke C Wenzel,Helge B Bode,Irene Kochems,Rolf Müller.  (2008-10-31)  A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin..  Chembiochem : a European journal of chemical biology,  ((16)): (2711-2721).  [PMID:18972512]
27. Qian Cao,Hong Zhao,Yujian He,Xiangjun Li,Lixi Zeng,Nan Ding,Jian Wang,Jie Yang,Guangwei Wang.  (2010-06-01)  Hydrogen-bonding-induced colorimetric detection of melamine by nonaggregation-based Au-NPs as a probe..  Biosensors & bioelectronics,  25  ((12)): (2680-2685).  [PMID:20510598]
28. Sloan Ayers,Tyler N Graf,Audrey F Adcock,David J Kroll,Susan Matthew,Esperanza J Carcache de Blanco,Qi Shen,Steven M Swanson,Mansukh C Wani,Cedric J Pearce,Nicholas H Oberlies.  (2011-04-26)  Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships..  Journal of natural products,  74  ((5)): (1126-1131).  [PMID:21513293]
29. Cui Li,Xiao-Peng He,Yin-Jie Zhang,Zhen Li,Li-Xin Gao,Xiao-Xin Shi,Juan Xie,Jia Li,Guo-Rong Chen,Yun Tang.  (2011-07-13)  Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold..  European journal of medicinal chemistry,  46  ((9)): (4212-4218).  [PMID:21745700]
30. Matti Marklund,Eric A Strömberg,Andrew C Hooker,Margareta Hammarlund-Udenaes,Per Aman,Rikard Landberg,Afaf Kamal-Eldin.  (2013-08-16)  Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats..  The Journal of nutrition,  143  ((10)): (1573-1578).  [PMID:23946349]
31. Dali Fu, Haodong Wang, Tan Wang, Chunming Xu, Yehua Han.  (2023)  Structural insights into variation of intramolecular acid site using phase transition experiments and computation.  AICHE JOURNAL,  70  (4): (e18342).  [PMID:]
32. Diqin Zhang, Yu Zhao, Bin Guo, Zhen Zhang, Dejiao Hu, Zhen Wang, Jianhua Zhu, Yan Ye, Yuxia Zhao.  (2023)  Acrylate dendritic monomers for fabricating holographic data storage media with high performance.  EUROPEAN POLYMER JOURNAL,  198  (112436).  [PMID:21418524]
33. Hui Yang, Guoming Yuan, Enxiang Jiao, Kunxin Wang, WenJie Diao, Zhao Li, Kun Wu, Jun Shi.  (2023)  Low dielectric constant and high thermal stability of liquid crystal epoxy polymers based on functionalized poly(phenylene oxide).  EUROPEAN POLYMER JOURNAL,  198  (112378).  [PMID:]
34. Naijie Wang, Xiangqun Chen, Qiu Sun, Ying Song, Tiezhu Xin.  (2023)  Fast Li+ Transport Polyurethane-Based Single-Ion Conducting Polymer Electrolyte with Sulfonamide Side chains in the Hard Segment for Lithium Metal Batteries.  ACS Applied Materials & Interfaces,  15  (33): (39837–39846).  [PMID:37552620]
35. Jian Yao, Lun Gui, Qizhang Long.  (2022)  A chlorogenic acid esterase from a metagenomic library with unique substrate specificity and its application in caffeic and ferulic acid production from agricultural byproducts.  BIOCATALYSIS AND BIOTRANSFORMATION,      [PMID:]
36. Qiqin Wang, Lingjue Sun, Huihui Wu, Ning Deng, Xianglong Zhao, Jingwei Zhou, Tingting Zhang, Hai Han, Zhengjin Jiang.  (2022)  Rapid fabrication of zwitterionic sulfobetaine vinylimidazole-based monoliths via photoinitiated copolymerization for hydrophilic interaction chromatography.  Journal of Pharmaceutical Analysis,  12  (783).  [PMID:36320596]

Solution Calculators