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3-Amino-1-propanesulfonic acid - 97%, high purity , Beta amyloid A4 protein stabiliser, CAS No.3687-18-1, Beta amyloid A4 protein stabiliser

4 Citations
  • ≥97%
Item Number
A107500
Grouped product items
SKUSizeAvailabilityPrice Qty
A107500-1g
1g
In stock
$58.90
A107500-5g
5g
In stock
$111.90
A107500-25g
25g
In stock
$504.90
A107500-100g
100g
In stock
$1,814.90
A107500-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$8,164.90
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Binds soluble amyloid-β. Antifibrillogenic.

View related series
Amyloid-β Neuronal Signaling Non heterocyclic block Sulfur containing compounds

Basic Description

SynonymsAcamprosate impurity A | KBio1_000348 | TRAMIPROSATE [MI] | 3-ammoniopropane-1-sulfonate | EINECS 222-977-4 | SCHEMBL26759 | 3-Amino-1-propanesulfonic acid | UNII-5K8EAX0G53 | 5K8EAX0G53 | GS-3103 | MLS000028639 | 1-Propanesulfonic acid, 3-amino- | AI3-52
Specifications & Purity≥97%
Shipped InNormal
Action TypeSTABILISER
Mechanism of actionBeta amyloid A4 protein stabiliser
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).

Product Properties

ALogP-3.8

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabbr1 GABA B receptor (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179632
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179632
IUPAC Name 3-aminopropane-1-sulfonic acid
INCHI InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
InChi Key SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Canonical SMILES C(CN)CS(=O)(=O)O
Isomeric SMILES C(CN)CS(=O)(=O)O
WGK Germany 1
PubChem CID 1646
Molecular Weight 139.17
Reaxy-Rn 1753803

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
K1520070Certificate of AnalysisJul 10, 2023 A107500
B2324297Certificate of AnalysisMar 02, 2023 A107500
D2401026Certificate of AnalysisJun 17, 2022 A107500
E2311124Certificate of AnalysisJun 17, 2022 A107500
I2227097Certificate of AnalysisJun 17, 2022 A107500
I2227098Certificate of AnalysisJun 17, 2022 A107500
H1809096Certificate of AnalysisJun 16, 2022 A107500
H1809095Certificate of AnalysisJun 16, 2022 A107500
B2314110Certificate of AnalysisDec 07, 2021 A107500
E2311118Certificate of AnalysisDec 07, 2021 A107500

Chemical and Physical Properties

Melt Point(°C)293°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 1
Reaxy-Rn 1753803

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Shaocheng Liu, Zhenyu Guo, Xianxin Wu, Xinfeng Liu, Zijian Huang, Liang Li, Jinwen Zhang, Huanping Zhou, Ling-Dong Sun, Chun-Hua Yan.  (2022)  Zwitterions Narrow Distribution of Perovskite Quantum Wells for Blue Light-Emitting Diodes with Efficiency Exceeding 15%.  ADVANCED MATERIALS,  35  (3): (2208078).  [PMID:36398427] [10.1002/adma.202208078]
2. Mengyue Hu, Xu Peng, Shubin Shi, Chang Wan, Can Cheng, Ningning Lei, Xixun Yu.  (2022)  Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets for synergistically enhancing hemocompatibility and cytocompatibility and reducing calcification.  Journal of Materials Chemistry B,  10  (40): (8218-8234).  [PMID:36173240] [10.1039/D2TB01704K]
3. Zhan Hao, Song Zhao, Qinghua Li, Yi Wang, Jun Zhang, Zhi Wang, Jixiao Wang.  (2021)  Reverse osmosis membranes with sulfonate and phosphate groups having excellent anti- scaling and anti-fouling properties.  DESALINATION,  509  (115076).  [PMID:] [10.1016/j.desal.2021.115076]
4. Yaojun Ju, Harapriya Chakravarty, Kin Yip Tam.  (2020)  An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer’s Disease.  ACS Chemical Neuroscience,  11  (20): (3346–3357).  [PMID:33001625] [10.1021/acschemneuro.0c00464]

References

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9. R Nageswara Rao,Pawan K Maurya,Dhananjay D Shinde,Sara Khalid.  (2011-02-18)  Precolumn derivatization followed by liquid chromatographic separation and determination of tramiprosate in rat plasma by fluorescence detector: application to pharmacokinetics..  Journal of pharmaceutical and biomedical analysis,  55  ((2)): (282-287).  [PMID:21324628]
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17. N M van Gelder,R J Bowers.  (2001-08-25)  Synthesis and characterization of N,N-dichlorinated amino acids: taurine, homotaurine, GABA and L-leucine..  Neurochemical research,  26  ((6)): (575-578).  [PMID:11519717]
18. Laurence Desrues,Hélène Castel,Maria M Malagon,Hubert Vaudry,Marie-Christine Tonon.  (2005-07-02)  The regulation of alpha-MSH release by GABA is mediated by a chloride-dependent [Ca2+]c increase in frog melanotrope cells..  Peptides,  26  ((10)): (1936-1943).  [PMID:15990198]
19. Tamsin M Wright.  (2006-06-28)  Tramiprosate..  Drugs of today (Barcelona, Spain : 1998),  42  ((5)): (291-298).  [PMID:16801992]
20. P S Aisen,D Saumier,R Briand,J Laurin,F Gervais,P Tremblay,D Garceau.  (2006-11-04)  A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease..  Neurology,  67  ((10)): (1757-1763).  [PMID:17082468]
21. Steven M Greenberg,Jonathan Rosand,Alexander T Schneider,L Creed Pettigrew,Samuel E Gandy,Barry Rovner,Brian-Fred Fitzsimmons,Eric E Smith,M Edip Gurol,Kristin Schwab,Julie Laurin,Denis Garceau.  (2006-11-30)  A phase 2 study of tramiprosate for cerebral amyloid angiopathy..  Alzheimer disease and associated disorders,  20  ((4)): (269-274).  [PMID:17132972]
22. Jutta Mayer,Karin Denger,Katrin Kaspar,Klaus Hollemeyer,Theo H M Smits,Thomas Huhn,Alasdair M Cook.  (2007-12-18)  Assimilation of homotaurine-nitrogen by Burkholderia sp. and excretion of sulfopropanoate..  FEMS microbiology letters,  279  ((1)): (77-82).  [PMID:18081842]
23. R Nageswara Rao,Pawan K Maurya,Dhananjay D Shinde,Sachin B Agwane.  (2010-12-15)  Reversed-phase liquid chromatographic determination of tramiprosate in rat plasma using evaporative light scattering detector..  Biomedical chromatography : BMC,  25  ((8)): (925-929).  [PMID:21154641]
24. Shuangchan Wu,Yuan Yue,Hui Tian,Li Tao,Yuting Wang,Jin Xiang,Shi Wang,Hong Ding.  (2014-04-29)  Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS..  Neuropharmacology,  83  (107-117).  [PMID:24769446]
25. Shaocheng Liu, Zhenyu Guo, Xianxin Wu, Xinfeng Liu, Zijian Huang, Liang Li, Jinwen Zhang, Huanping Zhou, Ling-Dong Sun, Chun-Hua Yan.  (2022)  Zwitterions Narrow Distribution of Perovskite Quantum Wells for Blue Light-Emitting Diodes with Efficiency Exceeding 15%.  ADVANCED MATERIALS,  35  (3): (2208078).  [PMID:36398427] [10.1002/adma.202208078]
26. Mengyue Hu, Xu Peng, Shubin Shi, Chang Wan, Can Cheng, Ningning Lei, Xixun Yu.  (2022)  Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets for synergistically enhancing hemocompatibility and cytocompatibility and reducing calcification.  Journal of Materials Chemistry B,  10  (40): (8218-8234).  [PMID:36173240] [10.1039/D2TB01704K]
27. Zhan Hao, Song Zhao, Qinghua Li, Yi Wang, Jun Zhang, Zhi Wang, Jixiao Wang.  (2021)  Reverse osmosis membranes with sulfonate and phosphate groups having excellent anti- scaling and anti-fouling properties.  DESALINATION,  509  (115076).  [PMID:] [10.1016/j.desal.2021.115076]
28. Yaojun Ju, Harapriya Chakravarty, Kin Yip Tam.  (2020)  An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer’s Disease.  ACS Chemical Neuroscience,  11  (20): (3346–3357).  [PMID:33001625] [10.1021/acschemneuro.0c00464]

Solution Calculators

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