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3-APPA (CGP 27492) - 100 mM/ml, high purity , CAS No.103680-47-3, Agonist of GABA B1;Agonist of GABA B receptor

Item Number
A275461
Grouped product items
SKUSizeAvailabilityPrice Qty
A275461-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$962.90

Potent, selective GABA B agonist. 1 ml water soluble pack.

Basic Description

SynonymsBDBM24184 | DTXSID201336775 | Phosphinic acid, (3-aminopropyl) | 3-Aminopropanephosphinic acid | UNII-QMT5SS3QRE | (3-aminopropyl)(hydroxy)oxo-$l^{5}-phosphanylium | AKOS006337792 | [3H]CGP27492 | [3H]-CGP27492 | PDSP1_001484 | QMT5SS3QRE | CGA-147823 | (
Specifications & PurityMoligand™, 100 mM/ml
Biochemical and Physiological MechanismsPotent, selective GABA B agonist (IC 50 = 5 nM).
Storage TempStore at 2-8°C,Desiccated
Shipped InWet ice
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GABA B1;Agonist of GABA B receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

KCTD8 Tbio BTB/POZ domain-containing protein KCTD8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABBR2 Tclin Gamma-aminobutyric acid type B receptor subunit 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABBR1 Tclin Gamma-aminobutyric acid type B receptor subunit 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCTD12 Tchem BTB/POZ domain-containing protein KCTD12 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCTD16 Tbio BTB/POZ domain-containing protein KCTD16 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TACR1 Tclin Neurokinin 1 receptor (6273 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABBR1 Tclin GABA-B receptor 1 (184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Adrenergic receptor beta (1214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABBR1 Tclin GABA-B receptor (281 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chrm1 Muscarinic acetylcholine receptor (3770 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra1b Adrenergic receptor alpha-1 (5652 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Htr2b Serotonin 2 (5-HT2) receptor (2078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Adenosine A1 receptor partial agonistPARTIAL AGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3]


Adenosine A1 receptor agonistAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Adenosine A1 receptor antagonistANTAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

DOI: [1]


PubMed: [1]


Adenosine A1 receptor agonistAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Adenosine A1 receptor antagonistANTAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Adenosine A1 receptor agonistAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3]


Adenosine A1 receptor agonistAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

Other: [1]


Adenosine A1 receptor antagonistANTAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

Other: [1]


Adenosine A1 receptor agonistAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens
Adenosine A1 receptor agonistAGONISTALA226Adenosine A1 receptorSINGLE PROTEINHomo sapiens

Other: [1]


PubMed: [1]


Names and Identifiers

IUPAC Name 3-aminopropyl-hydroxy-oxophosphanium
INCHI InChI=1S/C3H8NO2P/c4-2-1-3-7(5)6/h1-4H2/p+1
InChi Key MQIWYGZSHIXQIU-UHFFFAOYSA-O
Canonical SMILES C(CN)C[P+](=O)O
Isomeric SMILES C(CN)C[P+](=O)O
Alternate CAS 103680-47-3
PubChem CID 6335948
MeSH Entry Terms 3-aminopropanephosphinic acid;3-aminopropylphosphinic acid;3-aminopropylphosphonous acid;CGP 27 492;CGP 27492;CGP-27492
Molecular Weight 123.09

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
H2206773Certificate of AnalysisMay 12, 2023 A275461

Chemical and Physical Properties

SolubilitySoluble in 1ml of water to give specified mM/ml concentration

Related Documents

Solution Calculators