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3-Cyano-2-(1-methyl-1H-pyrazole-4-carboxamido)-N-(2-pyridinyl)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxamide , CAS No.C609380, Inhibitor of signal transducer and activator of transcription 3

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3-Cyano-2-(1-methyl-1H-pyrazole-4-carboxamido)-N-(2-pyridinyl)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxamide , CAS No.C609380, Inhibitor of signal transducer and activator of transcription 3

Moligand™

PubChem CID: 163358781

Item Number

C609380

Grouped product items
SKU	Size	Availability	Price	Qty
C609380-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C609380-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

signal transducer and activator of transcription 3 Inhibitor

Basic Description

Synonyms	compound 6f
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of signal transducer and activator of transcription 3

Associated Targets

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

Discover Target: SRC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT3 Tchem Signal transducer and activator of transcription 3 0 Activities

Discover Target: STAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 0 Activities

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 0 Activities

Discover Target: JAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 0 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-Cyano-2-(1-methyl-1H-pyrazole-4-carboxamido)-N-(2-pyridinyl)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxamide
INCHI	InChI=1S/C21H20N6O3S/c1-26-11-13(10-23-26)19(28)25-20-17(9-22)16-7-8-27(12-18(16)31-20)21(29)24-14-3-5-15(30-2)6-4-14/h3-6,10-11H,7-8,12H2,1-2H3,(H,24,29)(H,25,28)
InChi Key	WVYHDFDOBCBKGI-UHFFFAOYSA-N
Canonical SMILES	O=C(c1cn(C)nc1)Nc1c(C#N)c2c(s1)CN(C(=O)Nc1ccc(OC)cc1)CC2
Isomeric SMILES	CN1C=C(C=N1)C(=O)NC2=C(C3=C(S2)CN(CC3)C(=O)NC4=CC=C(C=C4)OC)C#N
PubChem CID	163358781

Database links

PubChem CID	163358781

Certificates

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References

1. Jin W, Zhang T, Zhou W, He P, Sun Y, Hu S, Chen H, Ma X, Peng Y, Yi Z et al.. (2022) Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.. J Med Chem, 129 (3): (589-97). [PMID:35476936]

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