3-Iodo-L-tyrosine - 10mM in Water, high purity , CAS No.70-78-0

  • 10mM in Water
Item Number
I425617
Grouped product items
SKUSizeAvailabilityPrice Qty
I425617-1ml
1ml
Available within 8-12 weeks(?)
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$49.90

Tyrosine hydroxylase inhibitor

Basic Description

Synonyms3-Iodo-L-tyrosine | 70-78-0 | H-Tyr(3-I)-OH | 3-IODOTYROSINE | L-Tyrosine, 3-iodo- | Monoiodotyrosine | (S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | 3-IODO-TYROSINE | IODOTYROSINE | 3-Monoiodo-L-tyrosine | (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | 3-Iod
Specifications & Purity10mM in Water
Biochemical and Physiological Mechanisms3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter. TH (tyrosine 3
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3)
Tyrosine hydroxylase inhibitor.

Associated Targets(Human)

TH Tclin Tyrosine 3-monooxygenase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TH Tclin Tyrosine 3-hydroxylase (13 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FPR1 Tchem Formyl peptide receptor 1 (1372 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
INCHI InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChi Key UQTZMGFTRHFAAM-ZETCQYMHSA-N
Canonical SMILES C1=CC(=C(C=C1CC(C(=O)O)N)I)O
Isomeric SMILES C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)O
WGK Germany 3
PubChem CID 439744
Molecular Weight 307.09
Beilstein 2941266
Reaxy-Rn 2941266

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SensitivityLight sensitive; Air sensitive; Heat sensitive
Specific Rotation[α]-3° (C=2,1mol/L Hcl)
Melt Point(°C)210°C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 2941266
Merck Index 5047

Related Documents

Citations of This Product

1. Qinhong Yin, Xiaolan Yang, Lihua Yang, Dezhi Yang, Yaling Yang, Yanqin Zhu.  (2023)  Cu, I-doped carbon dots as simulated nanozymes for the colorimetric detection of morphine in biological samples.  ANALYTICAL BIOCHEMISTRY,  680  (115313).  [PMID:37678583] [10.1016/j.ab.2023.115313]
2. Xiao Li, Yan Xu, Dimei Ouyang, Kefan Ye, Yiwen Chen, Qiulan Li, Qinghai Xia, Xiaomei Wu, Yaling Yang.  (2023)  Copper- and iodine-doped nanozymes with simulated enzyme activity and efficient antifungal activity against Candida albicans.  BIOCHEMICAL ENGINEERING JOURNAL,  191  (108791).  [PMID:] [10.1016/j.bej.2022.108791]
3. Yang Dezhi, Li Qiulan, Zhang Qian, Wang Yijie, Li Hong, Tammina Sai Kumar, Yang Yaling.  (2022)  A multifunctional nanozyme-based enhanced system for tert-butyl hydroquinone assay by surface-enhanced Raman scattering.  MICROCHIMICA ACTA,  189  (1): (1-9).  [PMID:34910256] [10.1007/s00604-021-05135-y]

References

1. Qinhong Yin, Xiaolan Yang, Lihua Yang, Dezhi Yang, Yaling Yang, Yanqin Zhu.  (2023)  Cu, I-doped carbon dots as simulated nanozymes for the colorimetric detection of morphine in biological samples.  ANALYTICAL BIOCHEMISTRY,  680  (115313).  [PMID:37678583] [10.1016/j.ab.2023.115313]
2. Xiao Li, Yan Xu, Dimei Ouyang, Kefan Ye, Yiwen Chen, Qiulan Li, Qinghai Xia, Xiaomei Wu, Yaling Yang.  (2023)  Copper- and iodine-doped nanozymes with simulated enzyme activity and efficient antifungal activity against Candida albicans.  BIOCHEMICAL ENGINEERING JOURNAL,  191  (108791).  [PMID:] [10.1016/j.bej.2022.108791]
3. Yang Dezhi, Li Qiulan, Zhang Qian, Wang Yijie, Li Hong, Tammina Sai Kumar, Yang Yaling.  (2022)  A multifunctional nanozyme-based enhanced system for tert-butyl hydroquinone assay by surface-enhanced Raman scattering.  MICROCHIMICA ACTA,  189  (1): (1-9).  [PMID:34910256] [10.1007/s00604-021-05135-y]

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