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3-Iodo-L-tyrosine - 10mM in Water, high purity , CAS No.70-78-0

10mM in Water

CAS#: 70-78-0
Formula: C₉H₁₀INO₃
Molecular Weight: 307.09
Beilstein Registry Number: 2941266
EC Number: 200-744-8
PubChem CID: 439744

Item Number

I425617

Grouped product items
SKU	Size	Availability	Price	Qty
I425617-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90

Tyrosine hydroxylase inhibitor

Basic Description

Synonyms	3-Iodo-L-tyrosine\|70-78-0\|H-Tyr(3-I)-OH\|3-IODOTYROSINE\|L-Tyrosine, 3-iodo-\|Monoiodotyrosine\|(S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid\|3-IODO-TYROSINE\|IODOTYROSINE\|3-Monoiodo-L-tyrosine\|(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid\|3-Iod
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter. TH (tyrosine 3
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3) Tyrosine hydroxylase inhibitor.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TH Tclin Tyrosine 3-monooxygenase 1 Activities

Discover Target: TH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR1 Tchem fMet-Leu-Phe receptor 0 Activities

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Discover Target: TXNRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Discover Target: SMN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC7A5 Tchem Large neutral amino acids transporter small subunit 1 0 Activities

Discover Target: SLC7A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

Discover Target: BLM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
INCHI	InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChi Key	UQTZMGFTRHFAAM-ZETCQYMHSA-N
Canonical SMILES	C1=CC(=C(C=C1CC(C(=O)O)N)I)O
Isomeric SMILES	C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)O
WGK Germany	3
PubChem CID	439744
Molecular Weight	307.09
Beilstein	2941266
Reaxy-Rn	2941266

Sensitivity

Light sensitive; Air sensitive; Heat sensitive

Specific Rotation[α]

-3° (C=2,1mol/L Hcl)

Melt Point(°C)

210°C

WGK Germany

Reaxy-Rn

2941266

Merck Index

5047

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